Ph.D., Biochemistry and Molecular Biology, University of Georgia, 2000
B.S. BIology, Virginia Tech, 1995
Kinetoplastid parasites cause a number of diseases that affect more than 70 people annually. Among this family are Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp, which cause human African trypanosomiasis, Chagas disease, and visceral, cutaneous and mucocutaneous leishmaniasis, respectively. There are no vaccines against these diseases and the current treatments are toxic and difficult to administer, making the search for new drug targets essential. In the search for new therapeutics we investigate essential parasite-specific processes, with the belief that understanding these processes will enable us to specifically target the parasite during treatments while leaving the host relatively unaffected. Kinetoplastid parasites harbor unique organelles, glycosomes, which are essential to parasite survival. The pathways that regulate glycosome biology are rich with potential drug targets. We use a number of biochemical and cell biology approaches to elucidate the mechanisms involved in glycosome biogenesis, maturation, maintenance and remodeling.
Bauer, ST, Morris, JC, Morris, MT. Environmentally-regulated glycosome protein composition in the African trypanosome. (In Press) Eukaryotic Cell.
Lin, S, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. Peptide targeted delivery of pH sensor for quantitative measurements of intraglycosomal pH in live Trypanosoma brucei. (In press) Biochemistry.
Joice, AC, Lyda, TL, Sayce, AC, Verplaetse, E, Morris, MT, Michels, PAM, Robinson, DR, Morris, JC. Extra-glycosomal localization of Trypanosoma brucei Hexokinase 2. (2012) The International Journal for Parasitology 42,401-409. (*Selected as “Editor’s Choice”)
5. Sharlow E, Golden JE, Dodson H, Morris M, Hesser M, Lyda T, Leimgruber S, Schroeder CE, Flaherty DP, Weiner WS, Simpson D, Lazo JS, Aubé J, Morris JC. Identification of inhibitors of Trypanosoma brucei hexokinases. (2010, updated 2011) Probe Report from the NIH Molecular Libraries Program. National Center for Biotechnology Information.
Dodson, HC, Morris MT, Morris JC. Glycerol-3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental change. (2011) The Journal of Biological Chemistry 286, 33150-33157.