Happy Birthday to EPIC
Join us as we celebrate our first year! Being one means some small growing pains, but many developments too. You can read about them here at the Clemson News Room. For those of you who missed the party, pictures can be found here.
New Publication Recognized as an "Article of Significant Interest" by Editor, Sheds Light on Parasite Cell Signaling
Amrita Koushik, a newly minted Ph.D. from the Department of Genetics and Biochemistry, in collaboration with her Ph.D. advisor, Dr. Lesly Temesvari, has recently published a portion of her thesis work on a critical parasite signaling pathway in the journal Eukaryotic Cell. The work, "A Genome-wide Over-Expression Screen Identifies Genes Involved in the Phosphatidylinositol 3-kinase Pathway in the Human Protozoan Parasite, Entamoeba histolytica", describes the development and use of the first forward genetics screening approach in the parastie to identify genes in signaling pathways in these important pathogen.
Two EPIC PIs, Drs. Meredith Morris and James Morris along with Drs. Ken Christensen and Christine Ackroyd (Department of Chemistry, Clemson University), were recently awarded an NIH Grant to measure the dynamic environmental conditions in an essential cellular structure in the African trypanosome, Trypanosoma brucei. Sugar metabolism, which is the sole source of nutrition for the infectious lifecycle stage of the African trypanosome, occurs exclusively in a part of the parasite called the glycosome. The proposed research would use both protein-based probes and small molecule sensors to measure intraglycosomal pH and glucose levels in live parasites, as a means to probe the mechanism of energy currency production and reveal regulatory mechanisms suitable for therapeutic targeting of glucose metabolism. For more information, go here.
Congratulations to the Newest EPIC Member on his Publication in mBio
Dr. Lukasz Kozubowski, a new Assistant Professor in EPIC and member of the Department of Genetics and Biochemstry, is lead author on an mBio paper, "Ordered Kinetochore Assembly in the Human-Pathogenic Basidiomycetous Yeast Cryptococcus neoformans", which explores the kinetchore dynamics in the pathogenic fungi C. neoformans. In this work, Dr. Kozubowski reports that surprisingly, kinetochore behavior in the fungi is more similar to that found in metazoans and less like that found in yeasts, which has implications in the evolution of mitosis. The pathogen that is the focus of the Kozubowski group, C. neoformans, is responsible for a potentially fatal fungal disease acquired by inhalation of infectious material from the environment.
The first ever Cell Biology of Eukaryotic Pathogens Symposium, sponsored by the American Society of Cell Biology, the Eukaryotic Pathogens Innovation Center (EPIC), the Center for Tropical and Emerging Global Diseases (CTEGD), the Department of Genetics and Biochemistry, and the College of Agriculture, Foresetry, and Life Sciences, was held at Clemson University on October 25, 2013. Approximately 80 students, post-doctoral fellows and faculty from five colleges and universities from South Carolina, Georgia and North Carolina were in attendance. Science related to pathogenic eukaryotes was presented in a series of short talks and through poster presentations, followed by a key note seminar by Dr. John Perfect, Duke University Medical School. (For more information, click here.) For more photos, click here.
ASCB Award given to fund Symposium bring reserarchers from Clemson University and the University of Georgia planned
The Cell Biology of Eukaryotic Pathogens Symposium, a joint meeting sponsored by reserachers from the Clemson University Eukaryotic Pathogen Innovation Center (EPIC) and University of Georgia’s Center for Tropical and Emerging Global Diseases (CTEGD), will showcase the cutting edge research of students, post-doctoral fellows, and primary investigators that focus on important emerging pathogens that impact the world. (For more info, click here.)