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Lesly Temesvari

Alumni Distinguished Professor
Interim Associate Dean for Research
Biological Sciences Department

Office: LSF 255B
Phone: 864-656-6387
Fax: 864-656-0435

Email: ltemesv@clemson.edu
 

 Educational Background

PhD Biological Sciences
University of Windsor 1993

BS Microbiology & Immunology
McGill University 1987

 Courses Taught

BIOL 4610 Cell Biology Lecture
BIOL 4620 Cell Biology Laboratory
BIOL 4920 Senior Seminar
BIOL 4940 Creative Inquiry-Popular Science Journalism
BIOL 6610 Graduate Level-Cell Biology
BIOL 8710 Graduate Level-Scientific Writing
BIOL 8490 Graduate Level-Understanding Scientific Communication

 Profile

Lesly A. Temesvari is an Alumni Distinguished Professor in the Department of Biological Sciences. She is currently serving as the Interim Associate Dean for Research in the College of Science. After post-doctoral work at the LSU Health Sciences Center, she joined Clemson’s faculty in 1999. She is a founding member of the Eukaryotic Pathogens Innovation Center (EPIC), a research group that is dedicated to understanding infectious diseases of global importance. Her own research focuses on characterizing virulence in the dysentery-causing human parasite, Entamoeba histolytica. Dr. Temesvari is the principal investigator on three National Institutes of Health (NIH) grants, including a $10.5 million center grant to EPIC. She has previously received grants from the National Science Foundation (NSF) and the Defense Advanced Research Project Agency (DARPA). Dr. Temesvari has served on numerous grant review panels at the NIH and NSF and, in 2010, held the Fulbright Chair in Research Methodology at the University of Siena in Siena, Italy

 Research Interests

The overall goal of the research in Dr. Temesvari's laboratory is to understand the pathogenesis of the human protozoan parasite, Entamoeba histolytica. This is the causative agent of amoebic dysentery and amoebic liver abscess; up to 50,000,000 people world-wide are infected annually. Secretion, phagocytosis, and parasite-host interactions are important virulence functions of E. histolytica. Thus, using state-of-art molecular, biochemical, genetic and cellular techniques, the Temesvari laboratory seeks to understand the virulence functions by studying (i) four Rab GTPases (master regulators of vesicle trafficking), (ii) several components of the PI 3-kinase signaling pathway, (iii) lipid rafts, and (iv) the stress-response in the pathogen. Insight gained through these studies may lead to rational design of novel anti-Entamoeba agents.

 Publications

2015 Kelso, A.A., Say, A.F., Sharma, D., Ledford, L.L., Turchick, A., Saski, C., King, A.V., Attaway, C.C., Temesvari, L.A., and Sehorn, M.G. Entamoeba histolytica Dmc1 Catalyzes Homologous DNA Pairing and Strand Exchange that is Stimulated by Calcium and Hop2-Mnd1. PLoS ONE (in press)

2014 Koushik, A.B., Welter, B. H., Rock, M.L., and Temesvari, L.A. A Genome-wide Over-Expression Screen Identifies Genes Involved in the Phosphatidylinositol 3-kinase Pathway in the Human Protozoan Parasite, Entamoeba histolytica. Eukaryotic Cell 13:401-411.
Editors’ Choice Feature Article

2013 Koushik, A.B., Powell, R.R., and Temesvari, L.A. Localization of phosphatidylinositol 4,5-bisphosphate to lipid rafts and uroids in the human protozoan parasite, Entamoeba histolytica. Infect Immun. Infect Immun. 81, 2145-2155.
2012 King, A.V., Welter, B.H., Koushik, A.B.*, and Temesvari, L.A. A Genome-Wide Over-Expression Screen Identifies Genes Involved in Phagocytosis in the Human Protozoan Parasite, Entamoeba histolytica, PloS ONE 7, e43025.

2012 Goldston A.M., Powell R.R., Koushik A.B., and Temesvari L.A. Exposure to Host Ligands Correlates with Co-localization of Gal/GalNAc Lectin Subunits in Lipid Rafts and PIP2 Signaling in Entamoeba histolytica. Eukaryot. Cell. 11, 743-751.
Editors’ Choice Feature Article

2011 Welter, B.H., Goldston, A.M., and Temesvari, L.A. Localisation to lipid rafts correlates with increased function of the Gal/GalNAc lectin in the human protozoan parasite, Entamoeba histolytica. Int. J. Parasitol. 41, 1409-1419.

2010 Byekova, Y.A., Powell, R.R., Welter, B.H., and Temesvari, L.A. Localization of phosphatidylinositol (3,4,5)-trisphosphate to phagosomes in Entamoeba histolytica using GST- and GFP-tagged lipid biosensors. Infect Immun. 78, 125-137.

2009 Welter, B.H., and Temesvari, L.A. Overexpression of a mutant form of EhRabA, a unique Rab GTPase of Entamoeba histolytica, alters endoplasmic reticulum morphology and localization of the Gal/GalNAc adherence lectin. Eukaryotic Cell. 8, 1014-1026.
Chosen as Cover for Eukaryotic Cell July 2009 Issue

2008 Mittal, K., Welter, B.H., and Temesvari, L.A. Entamoeba histolytica: Lipid rafts are involved in adhesion of trophozoites to host extracellular matrix components. Exp. Parasitol. 120, 127-134.