Biological Sciences Department
Office: 165 Jordan
PhD Molecular Biology
Peking University 1999
East China University of Science and Technology 1994
Micr4170/6170_Cancer and Aging
Biol/Micr4940/4941_Creative Inquiry (Aging Study)
Biol2000_Biology in News
2007 - Member of Institute of Engaged Aging, Clemson University
2002 - 2006 Research Associate, Cornell University
1999 - 2002 Postdoctoral Associate, Cornell University
Aging, Age-related Disorders, and Dietary Intervention: To live long and healthy is a fundamental human desire. With the advent of modern medicine, acute diseases became increasingly treatable, leaving the phenomenon of aging as our major health and lifespan determinant. In most of higher order eukaryotic organisms, aging is an inevitable universal process and associated with gradually declines of the physiological function, which may lead to a variety of age-related disorders. There is a desperate need to find a potent way that can delay aging and associated disorders. As aging is a long-term process, the most prevalent intervention of anti-aging with effectiveness is the supplementation of functional foods. Given that nutrients from functional foods may extensively interplay with genes, understanding the fundamental mechanisms of lifespan regulation in response to nutrients supplementation will provide valuable insights to develop molecular strategies to treat age-related disorders. It is known that many signaling pathways and lifespan determinants will form a sophisticated network to modulate lifespan and healthspan. I hypothesize that the regulatory network of longevity orchestrates the expression of genes in response to the treatment of nutrients from functional foods and thereby to promote longevity and health. Hence, my research centers on the understanding of how the longevity pathways interplay at the molecular level to modulate lifespan and healthspan in response to anti-aging intervention with functional foods.
Specifically, I dedicate to the following projects:
1. Mechanisms of lifespan regulation from a dietary intervention point of view.
2. Post-translational modifications of heat shock factor (HSF) 1 in response to anti-aging intervention.
3. Correlation of protein homeostasis (proteostasis) and Alzheimer's disease.
Guo H, Cao M, Zou S, Ye B, Dong Y*. (2015) Cranberry extract standardized for proanthocyanidins alleviates ß-Amyloid peptide toxicity by improving proteostasis through HSF-1 in Caenorhabditis elegans model of Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. doi: 10.1093/gerona/glv165.
Wang X, Cook L, Grasso L, Cao M, Dong Y*. (2014) Royal jelly-mediated prolongevity in Caenorhabditis elegans is modulated by the interplays of DAF-16, SIR-2.1, HCF-1, and 14-3-3 Proteins. J Gerontol A Biol Sci Med Sci. 70(7): 827-838. doi: 10.1093/gerona/glu120.
Dinh J, Angeloni JT, Pederson DB, Wang X, Cao M*, Dong Y*. (2014) Cranberry extract standardized for proanthocyanidins promotes the immune response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK pathway and HSF-1. PLoS ONE 9(7): e103290. doi: 10.1371/journal.pone.0103290. (* co-corresponding author)
Guha S, Natarajan O, Murbach C, Dinh J, Wilson E, Cao M, Zou S., Dong Y*. (2014) Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan. Nutrients. 6(2): 911-21. doi: 10.3390/nu6020911
Wang D, Cao M, Dinh J, Dong Y*. (2013) Methods for creating mutations in C. elegans that extend lifespan. Methods Mol Biol.; 1048:65-76. doi: 10.1007/978-1-62703-556-9_6
Guha S, Cao M, Kane R, Savino A, Zou S, Dong Y*. (2013) The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1. AGE 35(5):1559-1574. doi: 10.1007/s11357-012-9459-x
Guha S, Klees M, Wang X, Li J, Dong Y*, Cao M*. (2013) Influence of planktonic and sessile Listeria monocytogenes on Caenorhabditis elegans. Arch Microbiol. 195(1):19-26. (* co-corresponding author)
Dong Y*, Guha S, Sun X, Cao M, Wang X, Zou S. (2012) Nutraceutical interventions for promoting healthy aging in invertebrate models. Oxid Med Cell Longev. 2012:718491. Epub 2012 Sep 6. Review. (* the first and corresponding author)
Dong Y, Zou S. (2010) Sirtuins and Aging. In: Epigenetics of Aging (Ed.) T. O. Tollefsbol, Springer, New York, NY, USA, pp. 51-76. (Book Chapter)
Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee S. (2008) Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol. 6(9):e233