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Anthony Guiseppi-Elie

Anthony Guiseppi-ElieProfessor of Electrical and Computer Engineering
Professor of Chemical and Biomolecular Engineering
Professor of Bioengineering

Post Doc, 1983 - Massachusetts Institute of Technology
Surface Science
Sc.D., 1983 - Massachusetts Institute of Technology
Materials Science and Engineering
M.Sc., 1980 - University of Manchester Institute of Science and Technology
Chemical Engineering/Corrosion Science and Engineering
B.Sc. (First Class), 1979 - University of the West Indies
Applied Chemistry

Contact Information
Office: 132 Earle Hall
Office Phone: 864.656.1712
Fax: 864.656.1713

Center for Bioelectronics Biosensors and Biochips

Professor Guiseppi-Elie came to Clemson University after being a Professor of Emergency Medicine (SoM) and Professor of Chemical and Life Sciences Engineering (SoE) at Virginia Commonwealth University (1998-2006). He holds joint appointments as a Professor of Bioengineering, Professor of Electrical and Computer Engineering and serves as Director of the Center for Bioelectronics, Biosensors and Biochips, a plura-disciplinary faculty cluster represented by BioE, ChBE, Chemistry, ECE, and Mat. Sci. of the College of Engineering, Computing and Applied Sciences. Tony did his doctoral minor in International Business at the Sloan School and is Founder and Scientific Director of ABTECH Scientific, Inc., a near-patient biomedical diagnostics company. Tony has spent 15 years in intrapreneurial and entrepreneurial industrial research, product development and executive leadership at such companies as W. R. Grace and Co, Molecular Electronics Corporation, Ohmicron Corp. and ABTECH Scientific, Inc. Tony holds distinguished professorships at the University of the West Indies and the University of Western Cape. His research interests are in engineered bioanalytical systems in the service of human health and medicine. Tony has published ca. 200 technical papers and abstracts, 31 book or proceedings chapters, and holds 8 patents. Tony is a Fellow of the American Institute for Medical and Biological Engineering (FAIMBE), a sr. member of IEEE, a Life Member of AIChE and teaches engineering materials, biomolecular engineering, biosensors and bioelectronics, and nanobiotechnology.

Current Research
Prof. Guiseppi-Elie's research in electrical and computer engineering focuses on...

Bioelectronics and Organic Electronics: i) The synthesis and characterization of chemically and biologically responsive materials such as CNT-Enzyme supramolecular conjugates, CNT-conductive electroactive polymer (CEP) composites and their integration with CMOS technology such as in Enzyme-FETS and chemoresistors. ii) The clinically relevant applications of arrays of FETs and chemoresistors for electronic noses and electronic tongues used in "sniffing" and "tasting". iii) Signal processing and data fusion of plura-sensory data to aid decision making under uncertainty. iii) The application of bioimpedance to the understanding of tissue perfusion and its relation to wound healing and the development and clinical deployment of devices and systems for studying the etiology of chronic wounds and wound healing.

Biochips and Biofuel Cells: The development of implantable biochips for physiologic status monitoring. Research aims to integrate enzyme-based biotransducers, mixed signal electronics, low power devices and wireless communications into clinically relevant systems for monitoring during trauma and surgery and for monitoring in the intensive care unit (ICU). Enzyme biofuel cells are being developed as an in vivo energy source for powering implantable electronic devices. Biofuel cells use CNT-Enzyme supramolecular conjugates and exploits direct electronic transfer between enzymes and nanotemplated electrodes.

Nano and Microfabrication and BioMEMS: Design and fabrication of interdigitated arrays , microdisc arrays and arrays of arrays for biological detection. Integration of arrays into biomedical diagnostic devices The use of under potential electrodeposition to control the nanotopology, catalytic properties and interfacial impedance of metal/tissue interfaces.

Selected Publications

  • Anthony Guiseppi-Elie, Abdur Rub Abdur Rahman and Nikhil K. Shukla "SAM-modified Microdisc Electrode Arrays (MDEAs) With Functionalized Carbon Nanotubes" Elctrochimica Acta (2010) 55(14), 4247-4255 doi:10.1016/j.electacta.2008.12.043
  • Abdur Rub Abdur Rahman, Gusphyl Justin, Adilah Guiseppi-Wilson and Anthony Guiseppi-Elie* "Fabrication and Packaging of a Dual Sensing Electrochemical Biotransducer for Glucose and Lactate Useful in Intramuscular Physiologic Status Monitoring" IEEE Sensors Journal (2009) 9(12): 1856-1863 doi: 10.1109/JSEN.2009.2031347
  • Y. Zhou, B. Yu, A. Guiseppi-Elie, V. Sergeyev and K. Levon* "Potentiometric Monitoring of DNA Hybridization" Biosensors and Bioelectronics (2009) 24, 3275-3280. doi:10.1016/j.bios.2009.04.023
  • Abdur Rub Abdur Rahman, Gusphyl Justin and Anthony Guiseppi-Elie "Towards an Implantable Biochip for Glucose and Lactate Monitoring using Micro-Disc Electrode Arrays (MDEAs)" Biomedical Microdevices: BioMEMS and Biomedical NanoTechnology (2009) 11:1, 75.
  • Anthony Guiseppi-Elie*, Sung-Ho Choi, Kurt E. Geckeler, Balakrishnan Sivaraman, and Robert A. Latour "Ultrasonic Processing of Single-Walled Carbon Nanotube-Glucose Oxidase Conjugates: Interrelation of Bioactivity and Structure" NanoBiotechnology (2009), 4, 9-17. doi: 10.1007/s12030-009-9026-4 
  • Farahi, R. H.; Ferrell, T. L.; Guiseppi-Elie, A.; Hansen, P. Integrated electronics platforms for wireless implantable biosensors Life Science Systems and Applications Workshop (2007) IEEE/NIH, p 27-30. doi:10.1109/LSSA.2007.4400876