The EPIC Faculty consists of a team of dedicated scientists with interests that range from understanding mechanisms of drug resistance in fungal pathogens to fatty acid metabolism in kinetoplastid parasites. But we are united in our focus on some of the world's most troubling and neglected disease-causing organims.
Joshua Alper, Physics
My lab's goal is to understand the fundamental physical principles behind the mechanical coordination mechanisms of the molecular motors that drive oscillatory beating of mollie eukaryotic cilia and flagella.
Sourabh Dhingra, Biological Sciences
The overarching goal of Dhingra lab is to understand the molecular mechanisms associated with pathogenesis and azole drug tolerance in invasive pulmonary aspergillosis. We use molecular, biochemical and cellular approaches as well as murine models to understand the role of ncRNAs in pathobiology and azole drug tolerance of Aspergillus fumigatus.
Zhicheng Dou, Biological Sciences
My research focuses on proteolytic mechanisms during infection by the obligate intracellular parasite Toxoplasma gondii.
Cheryl Ingram-Smith, Genetics and Biochemistry
The overall goal of my research is to provide a better understanding of energy metabolism in the pathogenic protist Entamoeba histolytica.
Lukasz Kozubowski, Genetics and Biochemistry
We study a human fungal pathogen Cryptococcus neoformans to understand the mechanistic cellular processes used by pathogenic microorganisms to allow survival in the infected host.
Meredith Morris, Genetics and Biochemistry
In the search for new therapeutics we investigate essential parasite-specific processes, with the belief that understanding these processes will enable us to specifically target the parasite during treatments while leaving the host relatively unaffected.
James Morris, Genetics and Biochemistry
Our group is interested in elucidating the molecular mechanisms employed by the African trypanosome to detect glucose availability, with a particular focus on identifying unique components for targeting for therapeutics.
Kim Paul, Genetics and Biochemistry
My group is interested in the regulation of fatty acid metabolism in the African trypanosome.
Emily Rosowski, Biological Sciences
My lab is focused on understanding host-pathogen interactions, using the larval zebrafish as a model host. We are currently studying how innate immune mechanisms control infections with the fungus Aspergillus fumigatus.
Michael Sehorn, Genetics and Biochemistry
My laboratory strives to understand the mechanism of homology-directed repair of DNA double-strand breaks mediated by RAD51 and DMC1 in Saccharomyces cerevisiae, Entamoeba histolytica, and humans.
Kerry Smith, Genetics and Biochemistry
My group is interested in the acetate metabolism in the fungal pathogen Cryptococcus.
Lesly Temesvari, Biological Sciences
We seek to understand the virulence functions of secretion, phagocytosis, and parasite-host interactions in Entamoeba histolytica.
Daniel Whitehead, Chemistry
EPIC related projects in the Whitehead lab are focused on the synthesis of small molecules and conjugates for ther development of therapeutic and drug-delivery strategies for treating eukaryotic pathogen infections.