Ph.D. Biology, Massachusetts Institute of Technology, 2013
B.S. Biology, University of North Carolina at Chapel Hill, 2007
The Rosowski lab investigates host-pathogen interactions and the innate immune response to infections using the larval zebrafish host model. Cutting-edge imaging and genetic methods allow us to define the role of specific cell types and pathways in immune system function. One of our current interests is identifying pathways in macrophages that promote killing of the fungal pathogen Aspergillus fumigatus. We are also interested in how anti-fungal drugs function in vivo and synergize with host immune pathways.
The Zebrafish as a Model Host for Invasive Fungal Infections. Rosowski EE, Knox BP, Archambault LS, Huttenlocher A, Keller NP, Wheeler RT, Davis JM. J Fungi. 2018 Dec. doi: 10.3390/jof4040136. Review.
Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. Rosowski EE, Raffa N, Knox BP, Golenberg N, Keller NP, Huttenlocher A. PLoS Pathog. 2018 Aug. doi: 10.1371/journal.ppat.1007229.
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, Deng Q, Keller NP, Huttenlocher A. J Immunol. 2016 Dec. doi: 10.4049/jimmunol.1600928.
Neutrophil migration in infection and wound repair: going forward in reverse. de Oliveira S*, Rosowski EE*, Huttenlocher A. Nat Rev Immunol. 2016 May. doi: 10.1038/nri.2016.49. Review.
Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP. Infect Immun. 2014 Feb. doi: 10.1128/IAI.01291-13.
Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation. Rosowski EE, Saeij JP. PLoS One. 2012. doi: 10.1371/journal.pone.0051448.
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. Rosowski EE*, Lu D*, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP. J Exp Med. 2011 Jan. doi: 10.1084/jem.20100717.