Ph.D., Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center at Shreveport, 2002
B.S., Biology, New Mexico Tech, 1995
DNA double-strand breaks can result from exposure to endogenous sources such as free radicals and collapsed replication forks or through exposure to exogenous sources such as ionizing radiation. Efficient repair of these breaks is important to maintain genome stability. Homologous recombination (HR) is one of two major pathways that repairs DNA double-strand breaks. Homologous recombination is a major pathway that utilizes a template to mend DNA double-stranded breaks. This pathway contains numerous proteins including the RAD51 and DMC1 recombinases. My laboratory strives to understand the mechanism of homology-directed repair of DNA double-strand breaks mediated by RAD51 and DMC1 in Saccharomyces cerevisiae, Entamoeba histolytica, and humans.
Kelso, A.A., Goodson, S.D., Temesvari, L.A., Sehorn, M.G. (2016) Data on Rad51 amino acid sequences from higher and lower eukaryotic model organisms and parasites. Data Brief. 10:364-368. doi: 10.1016/j.dib.2016.12.002.
Kelso, A.A., Goodson, S.D., Watts, L.E., Ledford, L.L., Waldvogel, S.M., Diehl, J.N., Shah, S.B., Say, A.F., White, J.D., Sehorn, M.G. (2016) The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing. Nucleic Acids Res. 45(2):711-725. doi: 10.1093/nar/gkw877.
Kelso, A.A., Goodson, S.D., Chavan, S., Say, A.F., Turchick, A., Sharma, D., Ledford, L.L., Ratterman, E., Leskoske, K., King, A.V., Attaway, C.C., Bandera, Y.P., Foulger, S.H., Mazin, A.V., Temesvari, L.A., Sehorn, M.G. (2016) Characterization of the recombination activities of the Entamoeba histolytica Rad51 recombinase. Mol. Biochem. Parasitol. pii: S0166-6851(16)30124-4. doi: 10.1016/j.molbiopara.2016.09.001.
Jenkins, R., Bandera, Y.P., Daniele, M.A., Ledford, L.L., Tietje, A., Kelso, A.A., Sehorn, M.G., Wei, Y., Chakrabarti, M., Ray, S.K., Foulger, S.H. (2016) Sequestering survivin to functionalized nanoparticles: a strategy to enhance apoptosis in cancer cells. Biomater Sci. 4(4):614-26. doi: 10.1039/c5bm00580a.
Kelso, A.A., Say, A.F., Sharma, D., Ledford, L.A., Turchick, A., Saski, C.A., King A.V., Attaway, C.C., Temevari, L.A., Sehorn, M.G. Entamoeba histolytica Dmc1 catalyzes homologous DNA pairing and Strand exchange that is stimulated by Calcium and Hop2-Mnd1. (2015) PLoS One. Sep 30;10(9):e0139399. doi: 10.1371/journal.pone.0139399.
Sharma, D., Say, A.F., Ledford, L.L., Hughes A.J., Sehorn, H.A., Dwyer, D.S., Sehorn, M.G. Role of the conserved lysine within the Walker A Motif of human Dmc1. (2013) DNA Repair. 12(1):53-62.