Alumni Distinguished Professor
Ph.D., Biology, University of Windsor, 1993
B.Sc., Microbiology and Immunology, McGill University, 1987
The overall goal of the research in Dr. Temesvari's laboratory is to understand the pathogenesis of the human protozoan parasite, Entamoeba histolytica. This is the causative agent of amoebic dysentery and amoebic liver abscess; up to 50,000,000 people world-wide are infected annually. Secretion, phagocytosis, and parasite-host interactions are important virulence functions of E. histolytica. Thus, using state-of-art molecular, biochemical, genetic and cellular techniques, the Temesvari laboratory seeks to understand the virulence functions by studying (i) four Rab GTPases (master regulators of vesicle trafficking), (ii) several components of the PI 3-kinase signaling pathway, and (iii) lipid rafts. Insight gained through these studies may lead to rational design of novel anti-Entamoeba agents.
Welter BH, Sehorn MG, Temesvari LA. Flow cytometric characterization of encystation in Entamoeba invadens. Mol Biochem Parasitol. 2017 Dec;218:23-27. doi: 10.1016/j.molbiopara.2017.10.002. Epub 2017 Oct 14. PubMed PMID: 29037797; PubMed Central PMCID: PMC5682210.
2015 Kelso, A.A., Say, A.F., Sharma, D., Ledford, L.L., Turchick, A., Saski, C., King, A.V., Attaway, C.C., Temesvari, L.A., and Sehorn, M.G. Entamoeba histolytica Dmc1 Catalyzes Homologous DNA Pairing and Strand Exchange that is Stimulated by Calcium and Hop2-Mnd1. PLoS ONE (in press)
2014 Koushik, A.B., Welter, B. H., Rock, M.L., and Temesvari, L.A. A Genome-wide Over-Expression Screen Identifies Genes Involved in the Phosphatidylinositol 3-kinase Pathway in the Human Protozoan Parasite, Entamoeba histolytica. Eukaryotic Cell 13:401-411.
Editors’ Choice Feature Article
2013 Koushik, A.B., Powell, R.R., and Temesvari, L.A. Localization of phosphatidylinositol 4,5-bisphosphate to lipid rafts and uroids in the human protozoan parasite, Entamoeba histolytica. Infect Immun. Infect Immun. 81, 2145-2155.
2012 King, A.V., Welter, B.H., Koushik, A.B.*, and Temesvari, L.A. A Genome-Wide Over-Expression Screen Identifies Genes Involved in Phagocytosis in the Human Protozoan Parasite, Entamoeba histolytica, PloS ONE 7, e43025.