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Bioengineering and Bioimaging Core Instruments

Dr. Robert Latour, Core Director

1. HPLC/GPC system, Waters1. HPLC/GPC system, Waters

Applications: MW determination, high resolution separation and purification.


  • Binary Gradient Pumping System
  • Autosampler,
  • Photodiode Array Detector (Wavelength Range from 190 to 800 nm),
  • Refractive Index Detector (Refractive Index Range: 1.00 to 1.75 RIU),
  • Multi Lambda Fluorescence Detector (Operates from 200 to 900nm),
  • Column Heater (Temperature Range from 20oC to 60oC),
  • Fraction Collector

circular dichroism spector;2. Circular Dichroism Spectropolarimeter, Jasco J-810, Jasco Inc.

Specifications: Wavelength range from 163 to 900 nm

Peltier type temperature controller Jasco PFD-425S,
Automated pH titrator Jasco ATS-429S.


  • Allows to verify the chirality of molecules or compounds;
  • Using available software, fractions of each different conformation in protein structure can be estimated;
  • The conformational changes of molecules with temperature can be studied;
  • Useful for verifying that the protein is in its native conformation
  • Protein folding studies;
  • Purity testing of optically active substances

Surface Plasmon Resonance Spectroscopy (SPR) BiacoreX, GE Healthcare3. Surface Plasmon Resonance Spectroscopy (SPR) Biacore X, GE Healthcare

For measuring the interactions between proteins, nucleic acids, lipids, small molecules, and whole cells.


  • Temperature regulation from 4 to 40oC;
  • Flow rates 1-100 μL/min;
  • Required sample volume: injection volume (minimum 5 μL +20 μl);
  • Molecular weight detection: >180 Da;
  • Refractive index range from 1.33 to 1.40;
  • Sensitivity: 70000 RU*, where RU, resonance units, 1RU = 1 pg/mm2 of sensor surface.

Variable-Angle Spectroscopic EllipsometerSopraGES 5, Semilab4. Variable-Angle Spectroscopic Ellipsometer Sopra GES 5, Semilab

Measures layer thicknesses of thin film layers on flat substrates from monoatomic to several microns thick.


  • The beam size: 1 mm2 and 10 mm2;
  • The variable angles: from 7º to 90º with variable +/- 0.01º;
  • Spectral range from 200 nm to 800 nm.

Refractive index analysis instrument Reichert AR700, Reichert Inc.5. Refractive index analysis instrument Reichert AR700, Reichert Inc.


  • Reading range of 1.33000 to 1.60000 Refractive Index and the full Brix scale
  • Precision: to 0.01 Brix or 0.00001 RI

Flame atomic absorption spectrometer AAnalyst200, Perkin Elmer6. Flame atomic absorption spectrometer A Analyst 200, Perkin Elmer

Specifications: Wavelength range: from 189 to 900 nm.


  • For determining very precisely the concentration of a particular element in a liquid sample. Can detect from 1 to 1000 µg/L.
  • For each element, the specific lamp is required. Ca, Fe, and Cu lamps are available.

 Contact Angle Measuring Instrument DSA-20E, Krüss7. Contact Angle Measuring Instrument DSA-20E, Krüss

Completely automated drop creation, drop volume control, and drop rate.

  • Determination of static and dynamic contact angle by 5 methods including elliptical, polynomial, and height width;
  • Determination of surface and interfacial tension of liquids by pendant drop software

8. Materials Testing System Synergie100, MTS8. Materials Testing System Synergie100, MTS

Applications: Tensile, Flex, Peel/Tear, Strain, and Compression test methods.


  • Loading available: 10 N and 100 N (2 lbf );
  • Speed range: from 0.001 to 1000 mm/min (0.00004 to 39 in/min);
  • Max specimen thickness for grips: 13 mm (0.5 in);
  • 50 mm (2.0 inch) diameter lightweight compression platens;
  • Face set, 25x25 mm rubber, for 100/2000 advantage pneumatic and screw action grips.

Bose Electroforce3230 testing system, Bose9. Bose Electroforce 3230 testing system, Bose


  • Multi-specimen fatigue test;
  • Combined axial and torsion loading;
  • 450 N maximum force;
  • Sterilizable BioDynamic chambers for live tissue characterization

Electrospinning system, home build10. Electrospinning system, home build

Applications: aligned of randomly oriented nanofibers for scaffolds in tissue engineering, wound dressing, porous coatings, sutures, probes, etc.


  • Two regulated FC series high voltage power supplies from Glassman: 0-30kV with positive polarity and 0-12 kV with negative polarity;
  • NE-300 programmable syringe pump; and
  • controllable syringe heater with max.t =185°C from New Era, Inc.

Plasma cleaner/sterilizer, Harrick11. Plasma cleaner/sterilizer, Harrick


  • Removes organic contamination from surfaces;
  • Plasma activation of surfaces.


  • Expanded Pyrex plasma chamber 6″ diameter x 6.5″ length (15.24 cm x16.51 cm);
  • PlasmaFlo gas mixer;
  • Oxygen service pump.

Programmable compact spin coater VTC-100, MTI Corp12. Programmable compact spin coater VTC-100, MTI Corp.

Applications: Deposition of thin films on flat surfaces.

Features: 500 - 8000 RPM adjustable spinning speed

 Ultra Sound imaging system Vevo2100 , Fuji Film, Visual Sonics Inc.13. Ultra Sound imaging system Vevo2100 , Fuji Film, Visual Sonics Inc.


  • Real time non-invasive ultra sound imaging
  • Contrast imaging with dies;
  • Molecular imaging with nanoparticles;
  • For blood flow, vascularity, tissue stiffness, cardiac strain studies, and more.

VevoIVIS Lumina XR, Perkin Elmer14. Vevo IVIS Lumina XR, Perkin Elmer

Applications: Imaging animals with optical (Fluorescence, Bioluminescence) and X-Ray overlay

MicroCTSkyScan1176, Bruker15. MicroCT SkyScan 1176, Bruker


  • In vivo 3D imaging of small animals: rats and mice.
  • Wide range of imaging: from soft to hard tissue, to titanium implants.
  • 4D time resolved microtomography.