Current Projects

The overarching theme of SCBioMat is tissue regeneration through cell-biomaterials interactions using distinctive biomaterials-based approaches. Tissue regeneration involves bringing together scaffolds, cells, biological signals, and a microvascular network in three-dimensional constructs. A combination of factors working independently and in concert, such as scaffold composition, cell selection, cell-matrix interactions, and mechanical cues, determines the success of tissue regeneration; therefore, interdisciplinary research is required. Clemson University’s unique strengths in bioengineering, tissue engineering, biomaterials, and fiber and film technology are complemented by expertise in medicine and developmental biology at Medical University of South Carolina (MUSC) and University of South Carolina (USC).

Ten projects dedicated to crossdisciplinary tissue regeneration research are:

Stem Cell-Myocyte Electrical Coupling via a Laser Patterned Cell Bridge

Target Investigator: Dr. Bruce Gao

Biomaterials for Guided Neural Regeneration

Target Investigator: Dr. Ken Webb

Biomechanics and Mechanobiology of Atherosclerotic Plaque Failure

Target Investigator: Dr. Susan Lessner

Mechanically Guided Urological Tissue Regeneration in Vitro

Target Investigator: Dr. Jiro Nagatomi

Improved Reactor Control for Stem Cell Expansion to Meet Therapeutic Needs

Target Investigator: Dr. Sarah Harcum

Nanoparticles for Targeted Delivery of Neuroprotective Antioxidant Enzymes to CNS

Target Investigator: Dr. Alexey Vertegel

Combinatorial Development of Biomaterials for Cardiac Tissue Regeneration

Target Investigator: Dr. Ying Mei

Stem Cell Differentiation and Cardiovascular Tissue Engineering in Diabetes

Target Investigator: Dr. Agneta Simionescu

Neuron-specific Polymeric Micelle Delivery System for Neural Regeneration

Target Investigator: Dr. Jeoung Soo Lee

Pilot project:

Developing Non-Invasive Luminescent Tension-Indicating Orthopedic Screws

Target Investigator: Dr. Jeffrey Anker