Current Projects
The overarching theme of SCBioMat is tissue regeneration through cell-biomaterials interactions using distinctive biomaterials-based approaches. Tissue regeneration involves bringing together scaffolds, cells, biological signals, and a microvascular network in three-dimensional constructs. A combination of factors working independently and in concert, such as scaffold composition, cell selection, cell-matrix interactions, and mechanical cues, determines the success of tissue regeneration; therefore, interdisciplinary research is required. Clemson University’s unique strengths in bioengineering, tissue engineering, biomaterials, and fiber and film technology are complemented by expertise in medicine and developmental biology at Medical University of South Carolina (MUSC) and University of South Carolina (USC).
Seven projects dedicated to crossdisciplinary tissue regeneration research are:
Stem Cell-Myocyte Electrical Coupling via a Laser Patterned Cell Bridge
Target Investigator: Dr. Bruce Gao
Biomaterials for Guided Neural Regeneration
Target Investigator: Dr. Ken Webb
Biomechanics and Mechanobiology of Atherosclerotic Plaque Failure
Target Investigator: Dr. Susan Lessner
Enabling Technology for Brain Tissue Regeneration After Stroke
Target Investigator: Dr. Ning Zhang
Mechanically Guided Urological Tissue Regeneration in Vitro
Target Investigator: Dr. Jiro Nagatomi
Pilot projects:
Improved Reactor Control for Stem Cell Expansion to Meet Therapeutic Needs
Target Investigator: Dr. Sarah Harcum
Nanoparticles for Targeted Delivery of Neuroprotective Antioxidant Enzymes to CNS
Target Investigator: Dr. Alexey Vertegel