Cell Culture and Fermentation
Optimization Lab
  Graduate Students
Faraz Baig

Dan Odenwelder

I was born in Bethlehem, PA, and received my BS in Biopharmaceutical Engineering from Lehigh University in May 2012. At Lehigh, I was also a member of the men's soccer team and was a four year letter winner. Following graduation, I worked for a year in the Pharmaceutical Technology division at Sanofi Pasteur in Swiftwater, PA. My projects at Sanofi focused mainly on vaccine lyophilization and visual inspection. I began pursuing my PhD in Bioengineering at Clemson University in August 2013. I am currently investigating shifts in cancer cell metabolism using metabolic flux analysis (MFA). For my future research, I will use MFA to study iPS cell metabolism under various nutrient perturbations, with the ultimate goal of transitioning from small-scale cell cultures to fed-batch bioreactors.


Daniel Infante

Daniel Infante

I was born in Bogota, Colombia, and lived there until I was seven years old. I then moved to the United States and lived in Baltimore, MD, for a couple months before settling in Atlanta, GA, where I grew up. I received my BS in Bioengineering with a biomaterials concentration from Clemson University in May 2017. My undergraduate research involved investigating the structural degradation and calcification of bioprosthetic heart valves. For my MS project, I will be working with E. Coli and how a particular strain responds to different feeding methods.

Swadeel Gaad

Swadeel Gaad

I was born in Goa, India. I moved to Clemson to pursue my Master’s Degree in Electrical Engineering with Intelligent systems as my focus area. I have developed algorithms and tools for underwater image processing towards the completion of my bachelor’s degree in Electronics and Telecommunication at Goa College of Engineering. I have worked with robotics and Internet of things in my undergrad. I helped in developing “Bolt” which is an internet of things platform that helps you to control any household devices with your cell-phone or laptop over the internet. Currently I am working in collaboration with the Bioengineering department under Dr. Sarah Harcum and Electrical and Computer Engineering department under Dr. Richard Groff to develop adaptive control system for fast and stable growth for recombinant CHO cells.

Shahin Lashkari

Shahin Lashkari

I got my bachelor’s from Amirkabir University of Technology and my master’s from Sharif University of Technology both in mechanical engineering. Then I came to Clemson University to continue my studies. While studying at Clemson University, I became fascinated with interdisciplinary fields of research such as applying control concepts in bioengineering. I joined the team of graduate students supervised by Dr. Harcum and Dr. Groff from bioengineering and electrical engineering departments. My research is designing a controller which can set the appropriate feed rate based on the metabolic state of E. coli bacteria. By designing a robust metabolic state detector which can detect whether the cells are in oxidative or overflow state, the controller can increase or decrease the feed rate based on the response of the cells. The controller maintains the cells close to the boundary of oxidative and overflow (BOOM) states, which assures the efficient growth for the cells before and after the induction.

 

  Lab Technicians
Tom Caldwell

Tom Caldwell

Originally from Philadelphia, I moved to South Carolina in 2000 to attend the Citadel.  In 2004, I graduated with a BA in Chemistry and eventually moved on to Clemson University.  For the last 8 years I have worked for both Dr. Sarah Harcum and Dr. Ken Christensen as a lab manager and full-time researcher.  Much of my research with Dr. Harcum has been collaboration with Scarab Genomics in testing genetically modified E. coli. under the stress of high cell density fermentation (150+ O.D.).  Additional research has been conducted in the field of biofuels, specifically the use of switchgrass and sorghum syrup as alternative sugar sources in the production of ethanol.  Our labs also function as a proteomics facility.  We have the ability to develop, fine tune, and scale most protein production processes.  In my free time I enjoy looking for adventure high on the rocks with my wife.

  Alumni
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