Hunter Endowed Chair and Professor of Bioengineering; Professor of Electrical and Computer Engineering
Postdoctorate 1998 - Carolinas Medical Center
Ph.D., 1996 - Clemson University
M.S., 1992 - Clemson University
B.S., 1990 - North Carolina State University
Office: 401 Rhodes Research Center
Office Phone: 864.656.6462
Development of Absorbable Systems
Absorbable materials are advantageous in that they require no surgical retrieval after implantation, and, if designed appropriately, they absorb gradually with no lingering effects. Current projects include the evaluation of absorbable bioelastic materials, as well as the fabrication of absorbable materials conducive to vascular ingrowth. Additionally, the basic absorption mechanisms, such as autocatalytic effect, are investigated. This work is supported by Clemson University as well as the National Science Foundation.
Assessment of Cellular Adhesion
The cell-cell interaction and the cell-biomaterial interaction are both critical features of tissue engineering. Current research projects involve the development of customized polymeric substrates for vascular tissue engineering. This involves the design of bioreactor systems for vessel/valve development and analysis of cellular behavior in flow chambers. Related research efforts address the manipulation of stem cells for soft tissue engineering. This work is sponsored by DARPA.
Magnetic Resonance Imaging for Tissue Engineering Application
Absorbable polymers can be very sensitive to histological processing protocol. This effect is enhanced in tissue engineering systems, which are often highly porous with relatively low amounts of tissue. Noninvasive methods of imaging are being developed to assess tissue development within porous, absorbable systems, both in vitro and in vivo. This work is sponsored by the National Science Foundation and is in conjunction with the Center for in Vivo Microscopy laboratory at Duke University.
Development of Orthopaedic and Dental Tissue Engineering Devices
Pore topography plays a critical role in the attachment of cells to a porous substrate. Changes in pore size and shape can radically affect the successful development of tissue. This work is sponsored by the AO Foundation and investigates novel methods of modulating pore structure and designing absorbable systems specifically for orthopaedic and dental applications.