Department of Chemical and Biomolecular Engineering
University of Notre Dame
In the next decade, a new generation of protein and nucleic acid diagnostic devices will appear in the market. It will fundamentally transform health care, disease prevention and introduce a new multi-billion-dollar global industry in the process. Protein and nucleic acid biomarkers will be detected and quantified in whole blood, urine, sputum, water and food samples, with single molecule resolution and with a concentration dynamic range over 6 orders of magnitude, by inexpensive Point-of-Care turn-key instruments that can be operated by untrained personnel. Unlike current techniques, the devices will also be PCR-free and label-free. I shall review the myriad of scientific and engineering techniques that my lab has developed for this revolution: microfluidics for analyte concentration [3, 5, 9], dielectrophoretic molecular/cell trapping [1,4], surface acoustic wave pumping , shear-enhanced selectivity , ion-selective nanofluidics for electrical sensing without spurious electron transfer  and for pH control/actuation , plasmonic hotspots for low-cost optical sensing , ion-sensitive FET sensing without Debye screening , disposable biochip fabrication and architecture design, bioinformatics and wireless transmission etc. In particular, I will review a membrane-based $1 biochip, powered and controlled by laptops and manufactured in large-volume by low-cost spray [2,14] and wet assembly  production methods, that we have commercialized for bacteria detection in blood and drinking water.
 I.-F. Cheng, H.-C. Chang, D. Hou, and H.-C. Chang,Biomicrofluidics, 1, 021503(2007).
 N. Chetwani, S. Maheshwari, S. and H.-C. Chang Phys Rev Lett., 101, 204501 (2008).
 G. Yossifon and H.-C. Chang, Phys Rev Lett. 101, 254501(2008).
 S. Basuray, S. Senapati, A. Ajian, A. Mahon and H.-C. Chang, ACS Nano. 3, 1823 (2009).
 G. Yossifon, Y.-C. Chang and H.-C. Chang, Phys Rev Lett, 103, 154502(2009).
 Cheng, I.-F., S. Senapati, X. Cheng, S. Basuray, H-C Chang and H.-C. Chang,Lab-on-a-Chip,10, 828-831 (2010).
 S. Senapati, S. Basuray, Z. Slouka, L-J Cheng, L.-J. and H.-C. Chang, Topics in Current Chemistry, 304 , 153-169(2011).
 L.-J. Cheng and H.-C. Chang, Biomicrofluidics, 5, 046502 (2011).
 H.-C. Chang, G. Yossifon and E. A. Demekhin, Annual Rev of Fluid Mech, 44, 401-426 (2012).
 D. Taller, D.B. Go, D. B. and H.-C. Chang, Phys Rev Lett, 109, 224301 (2012).
 Z. Slouka, S. Senapati, Y. Yan and H.-C. Chang, Langmuir, 29, 8275-83 (2013).
 Y. Wang, F. Plouraboue, and H.-C. Chang, Optics Express, 21, 6609(2013).
 S. Maheshwari, L. Zhang, Y. Zhu and H.-C. Chang, Phys Rev Lett, 100, 044503 (2008).
 S. Maheshwari, S. and H.-C. Chang, Advanced Materials, 21, 349 (2009).
Prof. Chia Chang, the Bayer Professor of Engineering and Director of the Center for Microfluidics and Medical Diagnostics, is a leading researcher in micro/nanofluidics, particularly in the area of nano-electrokinetics. He has published a number of books, including a Cambridge University Press book on nano-electrokinetics. His group combines analysis and physical insight to discover new physical phenomena and to develop patented devices for technology transfer. More than 20 of his former PhD students are now teaching in leading academic universities throughout the world. Prof Chang is the founding Editor of Biomicrofluidics, an American Institute of Physics journal. He has received many awards including the Frankiel Award from the American Physical Society and the Presidential Young Investigator Award from NSF. A fellow of APS, he has delivered more than 20 keynote/plenary lectures and has more than 240 publications with over 8000 citations.
Thursday, November 21st, 2013
132 Fluor Daniel Building