Laboratory of Nanomedicine
Peer Reviewed Publications
These articles may be found online at Pubmed
  1. Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S.,"Study of the Initial Stages of Drug Release from a Degradable Matrix of Poly (d,l-lactide-co- glycolide)", Biomaterials 25, 813-821 (2004). 14609670
  2. Alexis, F., Rath, S. K, Venkatraman, S., "In Vitro Study of Release Mechanisms of Paclitaxel and Rapamycin from Drug-Incorporated Biodegradable Stent", Journal of Controlled Release 98, 67-74 (2004). 15245890
  3. Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., "Controlled drug release of bioerodible polymers: effect of drug type and composition", Journal of Controlled Release 102, 333-344 (2005). 15653155
  4. Alexis, F., "Factors Affecting Degradation and Drug Release Mechanisms of Bioerodible Polymers", Polymer International 54, 36-46 (2005).
  5. Alexis, F., Lo, S.L., Wang, S., "Covalent Attachment of Low Molecular Weight Polyethylenimine Improves Tat-Peptide Mediated Gene Delivery", Advanced Materials 18, 2174-2178 (2006).
  6. Tang, G.P., Zeng, S., Alexis, F., Yang, Y.Y., Wang, S., "Low Molecular Weight Polyethylenimine Copolymerized with B-cyclodextrin for Gene Delivery", Journal of Gene Medicine 8, 736-744 (2006).16550629
  7. Alexis, F., Rath, S. K., Gan, L-H., Venkatraman, S.,"Some Insight into Hydrolytic Scissions Mechanisms in Bioerodible Polyesters", Journal of Applied Polymer Science 102, 3111-3117 (2006). Abstract
  8. Zhang, L., Radovic-Moreno, A., Alexis, F., Gu, F.X., Basto, P., Langer, R, Farokhzad, O. C., "Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle-Aptamer Bioconjugates", ChemMedChem. 2, 1268-1271 (2007). 17600796
  9. Gu, F.X., Karnik, R., Wang, A. Z., Alexis, F., Levy-Nissenbaum, E., Hong, S., Langer, R., Farokhzad, O. C.," Targeted Nanoparticles for Cancer Therapy", NanoToday 2, 14-21 (2007). Abstract
  10. Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, A., Zhang, L., Langer, R., Molnar, L., Farokhzad, O. C.,"HER-2 Targeted Nanoparticle-Affibody Bioconjugates for Breast Cancer Therapy", ChemMedChem. 3, 1839-1843 (2008). PMC3515656
  11. Zhang, L., Chan, J. M., Gu, F.X., Rhee, J-W., Wang, A.Z., Radovic-Moreno, A., Alexis, F., Langer, R, Farokhzad, O. C., "Self-Assembled Lipid-Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform", ACS Nano 2, 1696-1702 (2008).19206374
  12. Alexis, F., Radovic-Moreno, A., Rhee, J-W, Richie, J. P., Langer, R., Farokhzad, O. C., "New Frontiers in Nanotechnology for Cancer Treatment", Journal of Urological Oncology 26. 74-85 (2008).18190835
  13. Wang, A. Z., Bagalkot, V., Vasilliou, C., Gu, F.X., Alexis, F., Zhang, L., Shaikh M., Yuet, K. , Cima, M., Langer, R., Farokhzad, O. C., Kantoff, P.W., Bander, N.H., Jon, S., Farokhzad, O. C., "Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy", ChemMedChem. 9, 1311-1315 (2008). 18613203
  14. Alexis, F., Pridgen, E., Langer, R., Farokhzad, O. C., "Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles", Molecular Therapeutics 5, 505-515 (2008). 18672949
  15. Loo, S.C.J., Moore, T., Banik, B., Alexis, F., "Biomedical Applications of Hydroxyapatite Nanoparticles", Current Pharmaceutical Biotechnology 11, 333-342 (2010). 20199383
  16. Zha, L., Banik, B., Alexis, F., "Stimuli Responsive Nanogels", Soft Matter 7, 5908-5916 (2011). Abstract
  17. Stone, R., Willi, T.J., Mefford, T., Rosen, Y., Alexis, F., "Targeted Magnetic Hyperthermia", Therapeutic Delivery 2, 815-838 (2011). 22822511
  18. Votruba, A.R., Mattix, B., Alexis, F., Bao, X., Michna, E., Janfaza, D., Farokhzad, O.C., Ross, E., "Nanotechnology and chronic pain management: small drug carriers with large implications for future pain treatments", Editorial for Pain, Submitted (2011).
  19. Banik, B., Alexis, F., "Spatial Functionalization of Polymeric Films", Cover page of Biomaterials Forum 33, 3, (2011).
  20. Xiao, Z., Levy-Nissenbaum, E., Alexis, F., Lupták, A., Teply, B.A., Chan, J.M., Shi, J., Digga, E., Cheng, J., Langer, R., Farokhzad, O.C., "Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection", ACS Nano 6, 696-704 (2012). 22214176
  21. Chen, H., Colvin, D. C., Qi, B., Moore, T., He, J., Mefford, O. T., Alexis, F., Gore, J. C., Anker, J. N., "Magnetic and optical properties of multifunctional core-shell radioluminescence nanoparticles", J. Mat. Chem. 22, 12802-12809 (2012). Abstract
  22. Chen, H., Moore, T.; Qi, B.; Colvin, D.C.; Jelen, E.; Hitchcock, D.A.; He, J.O.; Mefford, T.; Gore, J.C.; Alexis, F.; Anker, J.N. "Monitoring pH-triggered Drug Release from Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence." ACS Nano, 7, 1178-1187 (2013). 23281651
  23. Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. "Graphene coatings for enhanced hemo-compatibility of nitinol stents". RSC Advances , 3, 1660-1665 (2013). Abstract
  24. Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. "Graphene Coatings for Biomedical Implants". Journal of Visualized Experiments, 73, e50276 (2013). 23486380
  25. Moore, T.L., Pitzer, J., Podila, R., Wang, X., Lewis, R.L., Grimes S.W., Wilson, J.R., Skjervold, E., Brown, J., Rao, A., Alexis, F., "Polymer Coated Carbon Nanotubes to Safely Deliver Drugs", Particles and Particle Systems Characterization, 30, 299 (2013). Abstract
  26. Moore, T.L., Pitzer, J., Podila, R., Wang, X., Lewis, R.L., Grimes S.W., Wilson, J.R., Skjervold, E., Brown, J., Rao, A., Alexis, F. Cover Art in Particles and Particle Systems Characterization, Vol 30 (2013). Cover Art
  27. Chi, A.; Clayton, K.; Burrow, T.J.; Lewis, R.; Luciano, D.; Alexis, F.; D'hers, S.; Elman, NM; "Intelligent drug-delivery devices based on micro- and nanotechnologies". Therapeutic Delivery, 4, 77-94 (2013). 23323782
  28. Mattix, B.; Olsen, T.R.; Moore, T; Casco, M.; Simionescu, D.; Visconti, R; Alexis, "Accelerated Iron Oxide Nanoparticle Degradation Mediated by Polyester Encapsulation for Tissue Engineering Into Cellular Spheroids". Adv. Funct. Mat., In Press (2013). Abstract
  29. Chen, H.; Qi, B.; Moore, T.; Colvin, D.C.; Gore, J.C.; Alexis, A.; Mefford, O.T.; and Anker, J.N." Synthesis of brightly luminescent magnetic up-conversion nanophosphors for dual MRI and deep tissue imaging. Small (In Press, 2013). 23828629
  30. Mattix, B.; Olsen, T.R.; Gu, Y.; Casco, M.; Herbst, A.; Simionescu, D., Visconti, R. P., Kornev, K.G.; and Frank Alexis, "Biological Magnetic Cellular Spheroids as Building Blocks for Tissue Engineering", Acta Biomateriala, In Press (2013). 24176725
  31. Pridgen, E.M., Alexis, F., Kuo, T.T., Levy-Nissenbaum, E., Blumberg, R.S., Langer, R., Farokhzad, O.C., "Transepithelial Transport of Fc-Targeted Nanoparticles Across the Intestinal Epithelium Barrier by the Neonatal Fc Receptor for Oral Delivery", Science Translational Medicine, Accepted (2013). 24285486
  32. Mattix, B.; Olsen, T.R.; Casco, M.; Reese, L.; Poole, L.T.; Zhang, J.; Visconti, R.; Simionescu, A.; Simionescu, D.; Alexis, F. "Janus Magnetic Cellular Spheroids for Vascular Tissue Engineering", Biomaterials, In press (2013). 24183699
  33. Mattix, B.; Poole, T.; Casco, M.; Uvarov, O; Visconti, R. P.; Simionescu, D.; and Alexis F. "Small Diameter Vascular Grafts: Replacement Strategies, Maturation Techniques, and Challenges", Journal of Tissue Science & Engineering, In Press (2013). Abstract
  34. Moore, T.L.; Grimes, S.W.; Lewis, R.L.; Alexis, F."Multilayered Coated Carbon Nanotube to Deliver Dasatinib". Mol. Pharm., Accepted (2013). 24294824
  35. Moore, T.; Chen, H.; Morrison, R.; Wang, F.; Anker, J.N., Alexis, F. "Nanotechnologies for Non-invasive Measurement of In Vivo Drug Release". Mol. Pharma., Accepted (2013)
  36. Mattix, B., Moore, T., Uvarov, O., Pollard, S., O'Donnell, L., Park, K., Horne, D., Dhulekar, J., Olsen, T., Duong, N.; Burg, K.; Kraveka , J., Alexis, F. "Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment for Drug Delivery Applications". NanoLife, Accepted (2013)
  37. Ilyinskii, P.O., Roy, C.J.; O'Neil, C.P.; Browning, E.A.; Pittet, L.A.; Altreuter, D.H.; Alexis, F.; Tonti, E.; Shi, J.; Basto, P.A., Radovic-Moreno, A.F.; Iannacone, Langer, R.S., Farokhzad, O.C.; von Andrian,U.H.; Johnston, L.P.M.; and Kishimoto, T.K. "Adjuvant-Carrying Synthetic Vaccine Particles Augment the Immune Response to Encapsulated Antigen and Exhibit Strong Local Immune Activation without Inducing Systemic Cytokine Release". Submitted (2013)
  38. Chen, H.; Moore, T.; Qi, B.; Mefford, O.T.; Alexis, F.; and Anker, J.N. "Improving X-Ray and Up-Conversion Nanophosphor Cristallinity and Luminescence Intensity via a Confined Flux Method". Submitted (2013)
  39. Alexis, A.; and Anker, J.N."Theranostic nanotechnologies: moving beyond imaging the localization of the drug". Therapeutic Delivery (Editorial), Accepted (2013).
Book Chapters and Reviews
  1. Alexis, F., Zeng, J. & Wang S (2006). DNA Delivery/Gene Transfer Vector Manual Lab. PEI nanoparticles for targeted gene delivery. Chapter 3.6. Cold Spring Harbor Laboratory Press, NY (In Press 2006).
  2. Gu, F.X., Karnik, R., Wang, A.Z., Alexis, F., Levy-Nissenbaum, E., Hong, S., Langer, R. & Farokhzad, O.C. (2007). Targeted Nanoparticles for Cancer Therapy, NanoToday, 2, 14-21
  3. Alexis, F.; Zeng, J.; Wang, S., Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual, 1st edition (2007) , Cold Spring Harbor Laboratory Press, New York, NY.
  4. Alexis, F., Pridgen, E., Molnar, L.K., Farokhzad, O.C. (2008). Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles. Molecular Pharmaceutics; 5, 505-515. (Most accessed article in Molecular Pharmaceutics in 2008 and 2010).
  5. Alexis, F., Radovic-Moreno, A., Richie, J.P., Langer, R. & Farokhzad, O.C.(2008). New Frontiers in Nanotechnology for Cancer Treatment, Journal of Urological Oncology, 26, 74-85.
  6. Pridgen,E., Alexis, F., Langer, R. & Farokhzad, O.C. (2008). Biodegradable, Targeted Nanoparticles Formulations for Cancer Therapy. Methods in Bioengineering Book Series. Chapter 12. NY (In Press).
  7. Alexis, F., Pridgen, E., Langer, R. & Farokhzad, O.C. (2009). Nanoparticle Technologies for Cancer Therapy. Handbook of Experimental Pharmacology, 197, 55-96.
  8. Pridgen, E.; Alexis, F.; Farokhzad, O. C.; Langer, R., Methods in Bioengineering Book Series Nanoscale Bioengineering and Nanomedicine, 1st edition (2009), Artech House , Boston, MA.
  9. Alexis, F.; Pridgen, E.; Langer, R.; Farokhzad, O. C., Handbook of Experimental Pharmacology 197, 1st edition (2010), Springer, Berlin, Germany.
  10. Loo, S. C. J., Moore, T., Banik, B., Alexis, F. (2010). Biomedical Applications of Hydroxyapatite Nanoparticles. Curr. Biotechnol., 11, 333-342.
  11. Moore T., Graham E., Mattix M., Alexis F (2010). Nanoparticles to Cross Biological Barriers (Submitted).
  12. Zha L., Banik, B., Alexis F. (2010). Stimuli Responsive Nanogels. Soft Matter, (Accepted)
  13. Stone R., Willi T.J., Mefford T., Rosen Y., Alexis F. (2011). Therapeutic Delivery, (Accepted)
  14. Rosen, Y., Mattix, Rao A., Alexis, F. (2010). Carbon Nanotubes and Infectious Diseases. 2010, (Accepted).
  15. Votruba, A.R.; Mattix, B.; Alexis, F.; Bao, X.; Michna, E., Janfaza, D.; Farokhzad, O.C.; Ross, E (2011). Nanotechnology and chronic pain management: small drug carriers with large implications for future pain treatments. Pain, (Submitted).
  16. Kolishetti, N., Alexis, F., Pridgen, E., Farokhzad, O. C., Nanoplatform-Based Molecular Imaging, 1st edition (2011), John Wiley and Sons, Inc., Hoboken, NJ.
  17. Rosen, Y., Mattix, Rao A., Alexis, F. Nanomedicine in Health and Disease, 1st edition (2011), Taylor and Francis Group, LLC, Boca Raton, FL.
  18. Moore, T., Graham, E., Mattix, B., Alexis, F., Biomaterials Science: An Integrated Clinical and Engineering Approach, 1st edition (2012), Taylor and Francis Group, LLC, Boca Raton, FL.
  19. Venkatraman, S.; Keith, K.; Rosen, Y.; Huang, Y.; Steele, T.W.J.; Alexis, F., Polymers for Vascular and Urogenital Applications, 1st edition (2012), Taylor and Francis Group, LLC, Boca Raton, FL.
  1. Alexis, F., Farokhzad, O.C., Kuo, T., Pridgen, E., Radovic-Moreno, A. & Langer, R. (2007). Targeted Drug Delivery Using Human IgG Fc Fragment, PCT/US2007/85318, Licensed.
  2. Alexis, F., Zhang, L., Chan, J., Basto, P., Levy-Nissembaum, E., Langer, R. & Farokhzad, O.C. (2008). Poly (Amino Acid)-Targeted Drug Delivery, PCT/US08/05949, Licensed.
  3. Zhang, L., Radovic-Moreno, A., Gu, F.X.,  Alexis, F., Langer, R. & Farokhzad, O.C. (2008). Amphiphilic Compound Assisted Polymeric Particles for Targeted Delivery. PCT/US2008/059480, Licensed.
  4. Levy-Nissenbaum, E., Farokhzad, O.C., Langer, R. & Alexis, F. (2007). Oligonucleotide Systems for Targeted Intracellular Delivery. PCT/US2007/017539, Licensed.
  5. Alexis, F., Iannacone, M., Chi, J., Basto, P., Moseman, A., Von Andrian, U., Langer, R. & Farokhzad, O.C. (2008). Adjuvant Incorporation in Immunonanotherapeutics, US Patent Application 12/428,381, Licensed.
  6. Von Andrian, U., Farokhzad, O.C., Alexis, F., Iannacone, M., Basto, P., Chi, J., Moseman, A., Langer, R. (2008). Nicotine Immunotherapeutics (2008), PCT/US2008/428,408, Licensed.
  7. Alexis, F., Aizu, W., Kuo, T., Pridgen, E., Farokhzad, O.C. & Langer, R. (2008). Engineered Antibody and Antibody Fragments for Oriented Conjugation-Method of Preparation and Uses Thereof. 
  8. Von Andrian, U., Farokhzad, O.C., Langer, R., Tobias, J., Moseman, A., Zhang, L., Basto, P., Iannacone, M., Alexis, F. (2008). Vaccine Nanotechnology,PCT/US2008/011938, Licensed.
  9. Chi, J., Alexis, F., Iannacone, M., Moseman, A., Basto, P., Langer, R., Farokhzad, O.C. & Von Andrian, U. (2009). Targeting of Antigen Presenting Cells with Immunonanotherapeutics (2009), US Patent Application 12/428,295, Licensed.
  10. Iannacone, M., Alexis, F., Basto, P., Moseman, A., Chi, J., Langer, R., Farokhzad, O.C. & Von Andrian, U. (2009). Immunonanotherapeutics that Provides IgG Humoral Response Without T-Cell Antigen, PCT/US2008/428,388, Licensed.
  11. Frankel B., Alexis F. Delivery Systems for Enhancing Drug Efficacy (2011). Provisional Patent.
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