CURF Home>>Technology Showcase >>Stabilizing Multi-Well Plate Insert for Biomaterial Testing>>Proposed Method

Summary of Proposed Method:

  1. Biomaterial sample placed in each well
  2. Apparatus assembled
  3. Cells seeded as per normal procedures
  4. Incubate
  5. Evaluate cells
  6. Recover material via disassembling apparatus


Feature
Effect
Advantage
Temporary stabilization of material against multi-well plate Eliminates crushing / sliding damage to cells
  • Accurate evaluation of cell / material interaction
  Prevents material from curling
  • Useful for thin films or hydrophobic samples
  Secures materials that float
  • Accommodates wide variety of samples
Potential of liquid - tight seal between insert and material Restricts cellular growth to defined area
  • Simpler analyses
  • Permits surface area effect calculations
  • Useful for evaluation of surface treatments
  • Eliminates need for anti-adhesion coatings
Integrates with commercially available multi-well plates Maintenance of cells using normal cell culture technique
  • Convenience
  • Minimizes introduction of variables causing error
  Cells have normal access to media
  • Unlimited length of sample testing
Removal of insert compression removes sample stabilization Easy post-culture recovery of sample
  • Facilitates post-culture study of cell / material interface

 

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