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Senior Research Scientist and Associate Director
Center for Molecular Studies
J.C. Self Research Institute of Human Genetics
Greenwood Genetic Center
Research Professor (Adjunct)
Department of Genetics and Biochemistry
Dr. Srivastava is a senior research scientist and associate director of the Center for Molecular Studies at the Greenwood Genetic Center and an adjunct professor of Genetics and Biochemistry at Clemson University.
The research interest of his group is to understand the etiology of inherited neurodevelopmental disorders leading to intellectual disability (ID); affecting corticogenesis (Lissencephaly); or associated with aberrant behavior (Autism, Smith-Magenis syndrome). His group has identified and functionally characterized several X-linked and autosomal genes responsible for intellectual disability and autism, studied genes involved in other developmental disorders, contributed to the development of tools for diagnostic applications and identified treatment targets. He has considerable experience with the genes/proteins molecular and functional studies, whole exome and whole genome sequencing, whole genome and gene expression profiling, proteomics and metabolomics approaches and have applied these to study human and mouse developmental diseases. In collaborations with researchers at Clemson University, his group is applying “omics” approaches to look for changes in protein coding and long noncoding RNAs genes and metabolic profiling to better understand the genetic and biochemical mechanisms involved in the pathogenesis of autism and intellectual disability and to develop potential biomarkers for early diagnosis of autism cases that may also be utilized to develop effective therapies to ameliorate or treat the features of autism. Dr. Srivastava has run an independent lab for more than 20 years and has a long track record of collaborations and publications on the genetics of developmental disorders.
Clemson University related activities: Collaborative research with CU faculty, mentoring graduate students, participation in committees including faculty search, tenure and graduate student committees; develop a partnership between GGC and CU School of Nursing (Dr. Julia Eggert) Healthcare Genetics doctoral program; member, GGC-CU Center for Human Genetics Collaborative Management Team.
For more information, see his Curriculum Vitae.
Dr. Srivastava’s group has identified several disease genes, contributed to the development of tools for diagnostic applications and identified treatment targets. His studies have contributed significantly towards understanding the molecular mechanisms of several neurodevelopmental disorders including intellectual disability and autism. Furthermore, Dr. Srivastava and colleagues’ original discovery of human ectodermal dysplasia (EDA) gene and follow-up studies in human and mice have led to a recombinant protein drug that is in clinical trials for patients with EDA. Their research contributes to our knowledge of ID and autism-associated genomic regions and autosomal genes, including long noncoding RNA genes that play a potential role in ID and autism and open up new avenues of investigation into the causes of neurodevelopmental disorders. Their findings of autism-associated biomarkers and metabolic pathways provide insights into the pathogenetic mechanism underlying behavioral disabilities and provide tools for early diagnostic testing and approaches for curative or ameliorative therapies. The discovery of ASD-specific biomarkers provides immediate benefits for patients and their families by providing early diagnosis and risk counseling and altogether has the potential to significantly impact public health.
News and Media related to Dr. Srivastava’s work:
Inherited Abnormalities; Neurodevelopmental disorder; Autism spectrum disorder; Intellectual disability; Genomics, Transcriptomics, and Metabolomics