Department of Bioengineering
Contact 864-656-6576 or firstname.lastname@example.org
Will Richardson is an Assistant Professor in the Department of Bioengineering. Will received a B.S. in Biological Engineering with high honors from the University of Arkansas in 2007, a Ph.D. in Biomedical Engineering from Texas A&M University in 2012, and postdoctoral training in Biomedical Engineering at the University of Virginia as an American Heart Association Postdoctoral Fellow. In 2016, he joined Clemson University and started the Systems Mechanobiology Lab. The lab’s expertise is in matrix systems mechanobiology, focusing on the use of in silico systems modeling to identify cell and matrix processes regulating tissue structure, conducted alongside in vitro and in vivo experiments to test model predictions. Integrating these models and experiments, the lab pursues a multi-scale, systems-level understanding of tissue fibrosis in order to engineer novel technologies for controlling fibrotic remodeling via cell-matrix mechanobiology.
Mechanical loads are key regulators of tissue function in many disease conditions, including fibrosis - a growth and remodeling process characterized by excessive extracellular matrix accumulation. Controlling fibrotic remodeling offers broad and significant therapeutic opportunities for pathologies such as heart failure, musculoskeletal wound healing, pulmonary fibrosis, and others; however, this control will require understanding a complex system of cell and matrix processes including proliferation, differentiation, orientation, migration, matrix deposition, matrix degradation, and matrix reorganization, all of which can be highly mechanosensitive. Will’s lab is pursuing several projects that integrate computational and experimental models to better understand fibrotic mechanobiology and engineer novel technologies for controlling tissue fibrosis.
Biomechanics, Mechanobiology, Systems Biology, Fibrosis, Matrix Remodeling, Wound Healing, Computational Models, Precision Medicine