Hunter Endowed Chair
Department of Bioengineering
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Naren Vyavahare is a Hunter Endowed Chair and Professor of Bioengineering at Clemson University. Naren’s research and teaching interests are in heart valve biomaterials, site-specific therapies, and extracellular matrix remodeling in tissue regeneration. Naren is a Director of NIH-funded South Carolina Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT). Naren’s research is published in over 150 journal publications and conference proceedings and is in 6 book chapters. Additionally, Naren holds 13 international and US patents. Some of the patents are now licensed to companies to develop products. He has graduated 10 PhD students and 20 MS students as a major advisor. Naren is the recipient of many awards, including: the McQueen Quattlebaum Faculty Excellence Award and the Clemson University and Alumni Award for Outstanding Achievement in Research. He is a Fellow of American Institute of Medical and Biological Engineering (AIMBE). Naren is an active participant in several scientific societies and conference series. He chaired the Cardiovascular Biomaterials special interest group in the Society for Biomaterials and he was the chair of the North American Vascular Biology workshop in 2013. Prior to joining Clemson as a Professor, Naren served as a Research Assistant Professor at the University of Pennsylvania School of Medicine and the University of Michigan. His current research includes targeted treatments to restore extracellular matrix and tissue function in heart valves, aortic aneurysms, vascular calcification, chronic obstructive pulmonary disease (COPD), and skin disorders. His work is funded by the National Institutes of Health.
Naren has a broad background in cardiovascular disease pathology, biomaterials, and animal models for cardiovascular applications, with specific training and expertise in cardiovascular implants and targeted therapies. He has made major contributions to heart valve implants and one of the treatments that he researched to prevent calcification of heart valves is now clinically used. He also has made contributions to understanding the mechanisms of vascular calcification, and showed that matrix metalloproteinases are involved in elastin specific vascular calcification and elastin degradation in aortic aneurysms. His current research includes finding site-specific therapies to stabilize vascular structures so as to prevent or reverse calcification and aortic aneurysms. Naren has developed novel nanoparticles that can target drugs to disease sites in cardiovascular and pulmonary tissues.
Cardiovascular Diseases, Aortic Aneurysms, Atherosclerosis, Lung Diseases, COPD, Targeted Therapies, Heart Valve Implants