| Title: |
Adhesin-Specific
Nanoparticles And Process For Using Same |
| Case # |
237 |
| Inventors: |
Fred Stutzenbenger, Robert Latour, Ya-Ping
Sun, Tzuen-Rong Tzeng |
| Summary: |
The present invention is generally directed
to compositions useful in preventing and/or treating disease due
to infection by any of a variety of biologically active pathogenic
microorganisms. The compositions include nanoparticles formed
of a hydrophobic polymeric core, hydrophilic linking agents bound
to the core, and biofunctional materials bound to the linking
agents. The biofunctional materials are functionally identical
to receptors on host cell surfaces that can be recognized and
bound by adhesions on the surface of the targeted pathogenic adhesion-bearing
microorganisms. In one embodiment, the binding action between
the nanoparticles and the microorganisms can lead to the formation
of large agglomerated complexes, which can then be easily removed
from an area, including the digestive tract of an infected individual.
The compositions of the present invention can also be utilized
in preventing enteric infections via the ability to purge animals
of enteropathogens prior to transport and processing for human
consumption. |
| Applications: |
Nanoparticles could be used as a low
cost, specific purging agent for the removal of Campylobacter
jejuni (the most common poultry-associated human pathogen) from
chickens and turkeys prior to processing for market. Nanoparticles
could be used as therapeutic agents to cure or reduce chronic
bacterial, fungal or parasitic infections in the human digestive
tract. The application of nanoparticles as anti-bio-warfare agents
has great potential as surface decontaminates. Nanoparticles could
be clinically employed as a diagnostic tool for the identification
of pathogenic microorganisms having specific adhesins (i.e. agglutination
test). |
| Patent Status: |
Patent application has been filed. Detailed
information must be provided under a confidential disclosure agreement.
Please download the confidential disclosure form and mail the
completed form to:
Vincie Albritton, Associate Director
Clemson Research Park
Office of Technology Transfer
91 Technology Drive
A.M.R.L. Building, Room # 220
Anderson, SC 29625
PH: 864-656-5708
FAX: 864-656-0474
Email: valbrit@clemson.edu
|
| Licensing: |
The technology is available for non-exclusive
or exclusive field of use licensing. |
| Contact: |
For more information about this
technology, please contact:
Vincie Albritton, Associate Director
Phone: (864) 656-5708
Fax: (864) 656-0474
email: valbrit@clemson.edu
or
Janet Dillon, Project Administrator
Phone: (864) 656-4237
Fax: (864) 656-0474
email: gjanet@clemson.edu
Note: Don't forget to include the technology number in
your emails!
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