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Mark A. Blenner, Ph.D.

Mark A. BlennerMcQueen-Quattlebaum Associate Professor
Metabolic Engineering, Cellular Engineering, Synthetic Biology, Protein Engineering, Functional Genomics
Phone: 864-656-0290
Office: 207A Earle Hall

Mark Blenner with students in labEducation

Postdoc, Harvard Medical School, 2009-2012
Ph.D., Columbia University, 2009
M.S., Columbia University, 2006
B.S., Manhattan College, 2004

Research Interests:

Sustainable biochemical production; Natural product biosynthesis, biopharmaceutical production; protein secretion, waste valorization.

Our research group does application driven fundamental research to enable solutions to problems in sustainable chemical production, human health, and national defense, and space exploration.

Selected Publications (Full List Here)

Spagnuolo, M., Yaguchi, A., Blenner, M.* “Engineering of oleaginous yeast for biofuels production: recent advances and future directions.” Current Opinion in Biotechnology (In Press).

Schwartz, C., Cheng, JF., Evans, R., Schwartz, CA., Wagner, JM., Anglin, S., Beitz, A., Pan, W., Lonardi, S., Blenner, M., Alper, S., Yoshikuni, Y., Wheeldon, I. “Validating genome-wide CRISPR-Cas9 function in the non-conventional yeast Yarrowia lipolytica” BioRxiv (2018) PDF

Gao, D., Rodriguez, G., Shabbir Hussain, M., Blenner, M. “Dual CRISPR-Cas9 Cleavage in Yarrowia lipolytica Leads to Efficient Gene Excision” Biotechnology Journal doi: 10.1002/biot.201700590 (2018). PDF

Spagnuolo, M., Shabbir Hussain M., Gambill L., Blenner, M.*, “Unlocking Alternative Substrate Metabolism in Yarrowia lipolytica”, Frontiers in Microbiology 9:1077 (2018). PDF

Brabender, M., Shabbir Hussain, M., Rodriguez, G., Blenner, M. “Urea and Urine are Efficient Nitrogen Sources for Growth of Yarrowia lipolytica”, Applied Microbiology & Biotechnology 102(5):2313-2322 (2018)  PDF

Yaguchi, A., Spagnuolo, M., Blenner, M.* “Engineering Yeast for Utilization of Alternative Feedstocks” Current Opinion in Biotechnology 53:122-129 (2018).  PDF

Blenner, M. “Influence of Epigenetics on Bioprocessing” Chemical Engineering Progress (September 2018) PDF

Dasetty, S., Blenner, M.*, Sarupria, S.* “Engineering Lipases: Walking the Fine Line Between Activity and Stability” Materials Research Express – Emerging Investigators Awards Series 4:114008 (2017) PDF

Dasetty, S., Blenner, M.*, Sarupria, S.* “Engineering Lipases: Walking the Fine Line Between Activity and Stability” Materials Research Express – Emerging Investigators Awards Series 4:114008 (2017)  PDF

Bulutoglu, B., Dooley, K., Szilvay, G., Blenner M., and Banta, S. “Catch & Release: Fishing for target proteins with an evolved β-roll peptide exhibiting allosteric regulation. ACS Synthetic Biology 6(9):1732-1741. (2017) PDF

Yaguchi, A., Robinson A., Mihealsick E., Blenner, M. “Metabolism of Aromatic Compounds by Trichosporon oleaginosus While Remaining Oleaginous” Microbial Cell Factories 16:206. (2017) PDF

Shabbir-Hussain, M., Wheeldon, I., Blenner, M. “A Fatty Acid Transcriptional Sensor Built from Yarrowia lipolytica Upstream Activating and Regulatory Sequences” Biotechnology Journal 12(1):1-11. (2017) PDF

Yaguchi, A.‡, Rives, D.‡, Blenner, M. “The New Kids on the Block: Emerging Oleaginous Yeast of Biotechnological Importance”, AIMS Microbiology 3(2):186-206. (2017) PDF

Schwartz, C., Shabbir-Hussain, M., Frogue, K., Blenner, M., Wheeldon, I.* “Standardized markerless gene integration for pathway engineering in Yarrowia lipolytica”, ACS Synthetic Biology 6(3):402-409. (2017)  PDF

Rodriguez, G.‡, Shabbir-Hussain, M.‡, Gambill, L., Gao, D., Yaguchi, A., Blenner, M. “Engineering Xylose Utilization in Yarrowia lipolytica by Understanding its Cryptic Xylose Pathway” Biotechnology for Biofuels, 9:149. (2016) PDF

Schwartz, C., Shabbir-Hussain, M., Blenner, M., Wheeldon, I. “Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR-Cas9 Mediated Genome Editing in Yarrowia lipolytica” ACS Synthetic Biology, 5(4) 356-359. (2016) PDF

Shabbir Hussain, M., Gambill L., Smith, S., Blenner, M. “Engineering Promoter Architecture in Oleaginous Yeast Yarrowia lipolytica” ACS Synthetic Biology, 5(3) 213-223. (2016) PDF