Translational Research Improving Musculoskeletal Health Focus Group Team
Professor of Biophysics and Bioinformatics
Research Interests: Dr. Alexov's lab utilizes multiscale modeling approaches to elucidate the structure, dynamics and functional relationships of interacting compounds. He has a broad background in computational biophysics, with specific training and expertise in modeling macromolecules and their complexes. His research includes method and software development, investigations of molecular effects of human nsSNPs, structure-based drug discovery, revealing the role of electrostatics in molecular biology and methods for 3D structure predictions of proteins and protein complexes.
Associate Professor of Medicine, MUSC
Research Interests: Dr. Bradshaw's research interests are based in cell-ECM interactions and understanding collagen extracellular matrix assembly, and remodeling in a number of different tissues including joint tendons, periodontal ligament, heart, and dermis.
Associate Professor of Biophysics
Research Interests: Dr. Ding's research focuses on the multiscale modeling of biomolecules and molecular complexes to understanding the relationship between their structure, dynamics, and function. They are currently applying a multiscale modeling approach to uncover the structure, dynamics, and function relationship of osteoclast-specific V-ATPases and bone resorption for preventing osteoporosis.
Professor and ExxonMobil Employees Endowed Chair in Mechanical Engineering
Research Interests: Dr. Fadel's research efforts target the design process from early conception to pre-production. His work in optimization, packaging, metamaterial and multi-material design, additive manufacturing and design theory is well known and extensively cited. His current research emphasis is on the design and manufacture of highly functional heterogeneous objects, and of metamaterials, that is materials whose intrinsic properties are geometrically tuned to be different from those of their constitutive parts. The technology has been applied to the design and fabrication of orthopaedic devices and tools.
Professor of Bioengineering
Research Interests: Dr. Gao's research includes optics-based microscopic study of cell-cell and cell-ECM interactions under either engineered in vitro or embryonic in vivo microenvironments, including expertise in dynamic, nonlinear optical imaging of live tissues at the molecular level. One of his current aims is to improve osteoarthritis imaging techniques and diagnosis.
Director of Healthcare Innovation, CUBEInC Interim Director, SC Bioengineering Alliance and Medtranstech Program
Research Interests: Mr. Gara manages the life-science business incubator associated with Clemson University and Greenville Health System. He is responsible for company formation, funding, and commercial agreements with strategic partners and funding sources. He is also responsible for developing courses and lecture on medical technology commercialization for Clemson students and faculty.
Hansjörg Wyss Endowed Chair for Musculoskeletal Regenerative Medicine
Department of Bioengineering
Research Interests: Dr. Gilbert is the newest member in the SC-TRIMH program. At the Gilbert Research Lab, the primary objective is to foster interdisciplinary biomaterials research related to advanced and specialized metals, polymers, ceramics, and composite materials. His lab provides a rich environment for students to explore new ideas and develop the skills necessary to become leading researchers in Biomaterials. Gilbert is editor-in-chief of the Journal of Biomaterials Research. He was elected Fellow of the American Institute for Medical and Biological Engineers in 2004 and was inducted in 2012 as Fellow of the International Union of Societies of Biomaterials Science and Engineering. Gilbert was the founder of the Syracuse Biomaterials Institute at Syracuse University and was appointed in 2013 to the Medical Devices Committee of the Food and Drug Administration. He has been a consultant for numerous medical device companies and has published more than 160 peer-reviewed manuscripts or book chapters, 250 conference transactions and 10 patents.
Assistant Professor of Bioengineering
Research Interests: Implant Performance; Medical Device Reprocessing; and Translational Orthopaedic Research. Dr. Harman has successfully combined novel measurement technologies (e.g. video fluoroscopy, CT scans, and surgical navigation equipment) with clinical assessments to quantify prosthesis performance and predict clinical outcomes. Her current studies include computational model development using knee joint replacement alignment and geometry extracted from diagnostic images.
Kyle J. Jeray, M.D.
Academic Vice Chair and Professor of Orthopaedic Surgery, GHS
Research Interests: Orthopaedic traumatology, humerus fractures, synovial tissue, local bone graft techniques, treatment of osteoporosis and fragility fractures, bone healing and biomechanics.
Professor of Animal and Veterinary Science
Research Interests: Dr. Jones is a clinician scientist who specializes in veterinary radiology. Her research interests include lower back disease in working dogs and diagnostic imaging applications for experimental and natural animal models. She will support this focus group by assisting with development of large animal models, designing and validating diagnostic imaging protocols, and providing image analysis support for musculoskeletal research.
Michael J. Kissenberth, MD
Program Director, Steadman Hawkins Clinic of the Carolinas Shoulder Reconstruction and Sports Medicine Fellowship
Associate Professor of Orthopedic Surgery, USC School of Medicine - GHS
Associate Professor, Clemson University School of Health Research (CUSHR)
Dr. Kissenberth is an orthopedic surgeon specializing in sports medicine, complex shoulder reconstruction, arthroplasty and knee injuries resulting from sports, trauma, and aging. His research interests include biomechanics of the shoulder, youth throwing injuries, shoulder arthroplasty, rotator cuff injuries, biologics/regenerative medicine, and patient centered and value based medicine.
University and Attending Veterinarian
Research Interests: Dr. Parrish is currently the University and Attending Veterinarian at Clemson University and manages the centralized animal facility known as the Godley-Snell Research Center (GSRC). He is experienced in the care and experimental manipulation of small laboratory animals including mice, rats, fish, and guinea pigs, as well as nonhuman primates and larger species such as pigs, and sheep. He will support this focus group in developing musculoskeletal animal models.
Chair and Professor of Orthopaedics, MUSC
Research Interests: Dr. Pellegrini is a physician scientist. His current basic science research involves basic biology of bone formation, specifically the study of heterotopic ossification following hip surgery, the effects of radiation and other external stimuli on bone formation and the process of fracture repair, and traumatic battlefield blast amputation of the limbs as an inciting event for heterotopic ossification. His clinical research has focused on the prevention of venous thromboembolic disease (VTED) after total hip and knee arthroplasty and management of the related risk of pulmonary embolism
Assistant Professor of Materials Science and Engineering
Research Interests: Dr. Peng's research is focused on materials fabrication, processing and properties plus their applications in smart sensors. His current research is to develop smart miniature biosensors to monitor tissue and device function in vivo for hip joint replacement. The goal is to systematically establish the customizable and quantifiable surgery protocols to prevent or minimize osteolysis progression, based on the highly sensitive, embedded strain sensors, patient-specific biomechanical modeling, and cadaver/animal validation.
Research Interests: Dr. Reddy's science focuses upon (i) Molecular aspects of osteoclast and osteoblast/stromal cell biology and gene regulation (ii) Osteopetrosis animal models, congenital bone fractures in spinal muscular atrophy; Paget's disease of bone and (iii) Cancer metastasis to bone.
Assistant Professor Bioengineering
Research Interests: Mechanobiology, Cell-Matrix remodeling, Computational models. Dr. Richardson's overarching research goal is to link in silico, in vitro, and in vivo models for a multi-scale, systems-level understanding of matrix remodeling and engineer technologies to control fibrotic remodeling via cell-matrix mechanobiology in tendon repair.
Assistant Professor of Biophysics
Research Interests: Dr. Sanabria is an experimental and theoretical biophysicist whose research focus is to uncover the structure, dynamics, and functional interrelationship of biomolecules and molecular complexes. His training is in Physics, particularly fluorescent compounds used in the Förster Resonance Energy Transfer (FRET) technique to illuminate molecular interactions. He is currently collaborating with Dr. Feng Ding to apply a combined multiscale experimental and modeling approach to uncover the structure, dynamics, and functional relationship of osteoclast-specific V-ATPases, which is important for osteoclast-mediated bone resorption. The goal is to design therapeutic approaches to reduce the osteoclast-mediated bone resorption in osteoporosis.
Assistant Professor of Orthopedics, MUSC
Research InterestsOrthopedic Biomechanics; Mechanobiology; Tissue Engineering.
Dr. Wu's research is focused on soft tissue and bone interface: degeneration, injury and repair. By incorporating clinical assessments (e.g. bio-imaging, joint kinematics), in vitro tissue/cell studies, and in vivo animal model, his research goal is to develop a non-invasive function assessment tool (subject-specific multi-scale growth model) to help improve early diagnosis and treatment of musculoskeletal disease (e.g. neck and back pain, thumb osteoarthritis).
S.L. Bell Distinguished Professor of Electrical and Computer Engineering
Research Interests: Dr. Xaio's current research thrust areas include: 1) Novel optical/microwave micro/nano materials, structures, devices and sensors, 2) Fiber optic and microwave sensors and instrumentation for applications in harsh environments, 3) Ultrafast laser machining, processing/modification and characterization of materials and structures, and 4) Optical biomedical imaging, sensing, tomography/microscopy and spectroscopy.
Assistant Professor of Bioengineering
Research Interests: Osteoarthritis, Optical Imaging, Functional Imaging, Light-Matter Interaction. Dr. Ye's laboratory focuses upon developing new imaging technologies for in vivo and in vitro analysis. His team is currently working on new methodologies for osteoarthritis diagnosis and treatment.
Professor of Bioengineering
Executive Director, Institute of Biological Interfaces of Engineering (IBIOE)
Research Interests: Multiscale Computational Modeling of Biological Systems, Orthopaedic Biomechanics and Biomaterials, Testing and Evaluation of Biomaterials, Micro/Nanotechnology-Based Biosensors.
The South Carolina Translational Research Improving Musculoskeletal Health (SC-TRIMH) Focus Group is dedicated to furthering musculoskeletal research from the most basic levels to the implementation of clinical therapeutics. Our goal is to bring together Clemson University basic science researchers, engineers, and clinician scientists with expertise in, but not limited to, biophysics, material science, bioengineering, computational modeling, bioinformatics, supercomputing, optical imaging, smart sensor, design and fabrication, and clinical orthopaedic research to support musculoskeletal health research initiatives from the cell and molecular level to the whole body and population level.