Assistant Research Scientist
Greenwood Genetic Center
Contact: 864-388-1723 or firstname.lastname@example.org
Dr. Chen obtained a BS degree in Forestry from Taiwan National University and an MS degree in Forest Ecology also from Taiwan National University. He later received an MA degree in Ecology and Evolution from State University of New York at Stony Brook. Dr. Chen earned his PhD in Genetics from State University of New York at Stony Brook. He completed his postdoctoral training in Molecular Immunology at the Division of Hematology and Oncology, School of Medicine, University of Pennsylvania.
He has long-term collaborations with two faculty members in the School of Computing: Drs. James ZJ Wang and Feng Luo. He has collaborations with faculty members in the School of Nursing: Drs. Julie Eggert and Jane DeLuca. Dr. Chen frequently interacts with the faculty in the Department of Biological Sciences: Drs. Jeremy Tzeng, David Feliciano, Lesly Temesvari, and Charles Rice.
For more information, see his Curriculum Vitae.
Dr. Chen’s research concentrates on understanding the biological basis of the human genetic diseases and recently, mainly on Autism Spectrum Disorder (ASD). Using a combination of experimental and computational approaches, he and his colleagues are delineating the roles of circadian rhythms and network biology in the pathogenesis of ASD. With perspectives of systems biology and precision medicine, they investigate each individual ASD patient for identification of molecular targets in circadian pathways and for integration the complex information of network biology. They found that in cells of patients with ASD, the expressions of circadian clock genes are more likely (to be dysregulated odds ratio ~3.85), compared to controls. The gene-gene interaction network in cells of patients with ASD is also more likely to be dysregulated.
In collaboration with Dr. Walter Kaufmann, Director of the Center for Translational Research (CTR) at the Greenwood Genetic Center, he contributes to the data analysis for a research project on biomarkers and outcome measures of Rett Syndrome.
Autism Spectrum Disorder (ASD), Systems biology, Precision medicine, Circadian rhythm pathway analysis, Molecular network, Bioinformatics, Biostatistics, Big data analysis