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Jessica M. Larsen, Ph.D.

Jessica M. KellyAssistant Professor
Drug Delivery, Biomaterials, and Nanotechnology
Phone: 864-656-2621
Office: 209 Earle Hall

Ph.D., Auburn University
B.S., University of Virginia

Research Interests:

Drug Delivery, Biomaterials, and Nanotechnology

Professor Larsen’s research is centered on biomimetic and polymeric materials for drug delivery applications in neurodegenerative disease and other brain disorders. Her current research focuses on the development of advanced material amphiphiles to enhance enzyme delivery in neurodegenerative disease. In these efforts, Professor Larsen utilizes a variety of nanoparticle characterization techniques, as well as in vitro and in vivo therapeutic analysis, working at the interface of biology and engineering. Through careful development of biologically-relevant nanocarriers, Dr. Larsen hopes to bring next-generation nanomedicine with both disease-specificity and patient-personalization to the clinic.

Selected Publications

6. Kelly, J.M.; Martin, D.R.; Byrne, M.E. “Polyethylene glycol-b-Poly(lactic acid) Polymersomes as Vehicles for Enzyme Replacement Therapy”, Nanomedicine, 2591-2606, (2017). PMCID: 29111890

5. Kelly, J.M.; Kelly, J.M., Bradbury, A. M., Martin, D.R., Byrne, M.E. (2017). Emerging Therapies for Neuropathic Lysosomal Storage Disorders. Progress in Neurobiology. 152, 166-180. PMCID: 27725193

4. Kelly, J.M.; Pearce, E. E.; Martin, D.R.; Byrne, M.E. Lyoprotectants Modify and Stabilize Self-Assembly of Polymersomes. Polymer. 2016, 316-322.

3. Larsen, J. M.; Martin, D. R.; Byrne, M. E. Recent Advances in Delivery through the Blood-Brain Barrier.Curr. Top. Med. Chem. 2014, 1148–1160.

2. Larsen, J.M.; Pearce, E. E.; Martin, D.R.; Byrne M.E. Polymersomes: Towards Treatment of Neurodegenerative Disorders through Enzyme Replacement Therapy. Trans. Soc. Biomater., 39, 2015.

1. Larsen, J.M.; Martin, D.R.; Byrne, M.E. Synthesis and Engineering of Polymersomes for Treatment of Lysosomal Storage Disease. Trans. Soc. Biomater., 38, 2014.