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Current Projects

The overarching theme of SCBioCRAFT is tissue regeneration through cell-biomaterials interactions using distinctive biomaterials-based approaches. Tissue regeneration involves bringing together scaffolds, cells, biological signals, and a microvascular network in three-dimensional constructs. A combination of factors working independently and in concert, such as scaffold composition, cell selection, cell-matrix interactions, and mechanical cues, determines the success of tissue regeneration; therefore, interdisciplinary research is required. Clemson University’s unique strengths in bioengineering, tissue engineering, biomaterials, and fiber and film technology are complemented by expertise in medicine and developmental biology at Medical University of South Carolina (MUSC) and University of South Carolina (USC).

Project I — Developing Luminescent Strain Sensors to Evaluate and Monitor Osteoinductive Therapies
Target investigator: Jeff Anker, Associate Professor of Chemistry, Clemson University

Project II — Targeted Nano-therapeutics for Neural Regeneration
Target Investigator: Jeuong Soo Lee, Assistant Professor Bioengineering, Clemson University

Project III — Bioinformatics and polymer microarrays enabled development of injectable hydrogels for therapeutic angiogenesis
Target Investigator: Ying Mei, Assistant Professor of Bioengineering, Clemson University MUSC Campus

Project IV — Diabetes-resistant tissue engineered small diameter vascular grafts
Target investigator: Agneta Simionescu, Assistant Professor Bioengineering, Clemson University

Project V — Role of DCHS1 in Mitral Valve Development
Target Investigator: Russell (Chip) Norris, Assistant Professor, MUSC 

Project VI — Rational Approaches to small molecule-based tissue engineering
Target Investigator: Ann Foley, Assistant Professor Bioengineering, Clemson University MUSC Campus

Project VII — Promoting Intervertebral Disc Regeneration via Novel Biomaterials and by Modulating Inflammation
Target Investigator: Jeremy Mercuri, Assistant Professor Bioengineering, Clemson University

Pilot Project I — Mechano-Adaptive Fibrosis Signaling for Post-Infarct Therapy
William Richardson, Assistant Professor Bioengineering, Clemson University

Pilot Project II — Turning Etiologies of Fibrosis across Organs into Remedial Therapies 
Shibnath Ghatak, Research Assistant Professor, MUSC

Pilot Project III — Hematopoietic-derived cell - endocardium crosstalk in mitral valve homeostasis
Zoltan Hajdu, Assistant Professor, VCOM

COBRE Center worker at Clemson University, Clemson South Carolina