Assistant Professor
Ph.D. Biomedical Engineering, Georgia Institute of Technology and Emory University 2015
Research Interests
Genome editing
Gene Therapy
In vitro disease models
Point-of-care diagnostic and monitoring tools
Email rcottle@clemson.edu
Office 304 Rhodes Annex
Phone 864-656-3071
The Cottle Group: improve the lives of patients with inherited metabolic diseases
Gene editing approaches to treat diseases
Design of CRISPR-Cas technologies
Targeted gene editing
Off-target analysis using next generation sequencing
Transcriptome analysis
Ex vivo gene editing in hepatocytes
Electroporation-mediated delivery
Lipid nanoparticle-mediated delivery
Engraftment of gene modified hepatocytes in the liver
3D Culture platforms for hepatocytes
Novel functionalized scaffold-based 3D culture system
Spheroid culture system
Disease models of inherited metabolic diseases for drug screening
Diagnostic and monitoring tools for inherited metabolic diseases
Amino acid point-of-care monitoring devices and assays