Institute for Biological Interfaces of Engineering

3D Systems in the News

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  • Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules
    Thu, 26 Feb 2015 11:46:06 EST
  • Cancer stem-like cells (CSCs) are rare subpopulations of cancer cells that are reported to be responsible for cancer resistance and metastasis associated with conventional cancer therapies. Therefore, effective enrichment/culture of CSCs is of importance to both the understanding and treatment of cancer. However, it usually takes approximately 10 days for the widely used conventional approach to enrich CSCs through the formation of CSC-containing aggregates. Here we report the time can be shorte...

  • Positive impact of IGF-1-coupled nanoparticles on the differentiation potential of human chondrocytes cultured on collagen scaffolds
    Thu, 26 Feb 2015 11:46:06 EST
  • PURPOSE: In the present study, silica nanoparticles (sNP) coupled with insulin-like growth factor 1 (IGF-1) were loaded on a collagen-based scaffold intended for cartilage repair, and the influence on the viability, proliferation, and differentiation potential of human primary articular chondrocytes was examined. METHODS: Human chondrocytes were isolated from the hyaline cartilage of patients (n=4, female, mean age: 73+/-5.1 years) undergoing primary total knee joint replacement. Cells were dedi...

  • Osteogenic differentiation of human mesenchymal stem cells in 3-d zr-si organic-inorganic scaffolds produced by two-photon polymerization technique
    Thu, 26 Feb 2015 11:46:05 EST
  • Two-photon polymerization (2PP) is applied for the fabrication of 3-D Zr-Si scaffolds for bone tissue engineering. Zr-Si scaffolds with 150, 200, and 250 mum pore sizes are seeded with human bone marrow stem cells (hBMSCs) and human adipose tissue derived stem cells (hASCs) and cultured in osteoinductive and control media for three weeks. Osteogenic differentiation of hASCs and hBMSCs and formation of bone matrix is comparatively analyzed via alkaline phosphatase activity (ALP), calcium quantifi...

  • Increased proliferation and adhesion properties of human dental pulp stem cells in PLGA scaffolds via simulated microgravity
    Thu, 26 Feb 2015 11:46:04 EST
  • AIM: To explore the possibility of utilizing a rotary cell culture system (RCCS) to model simulated microgravity and investigate its effects on the proliferation, adhesion, migration and cytoskeletal organization of human dental pulp stem cells (hDPSCs) on Poly (lactic-co-glycolic acid) (PLGA) scaffolds. METHODOLOGY: Isolated and identified hDPSCs grown on PLGA scaffolds were exposed to simulated microgravity (SMG) or normal gravity (NG) conditions for 3 days. MTT cell proliferation assays, BrdU...

  • 3D - a new dimension of in vitro research
    Thu, 26 Feb 2015 11:46:04 EST
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