Office of Research

Guidance and Resources

The Animal Use Protocol (AUP) is required by animal welfare regulations.  The information requested in the “Clemson University Protocol for Use of Live Vertebrates” is based on:

All animal activities must be conducted in accordance with the PHS Policy on the Care and Use of Laboratory Animals, in accordance with the CU PHS Assurance Number A3737-01 (expires May 31, 2018) and in accordance with AAALAC International standards (continued full accreditation issued June 24, 2015).

Exceptions to the recommendations in the ILAR Guide, the Agricultural Guide, and the AVMA Guidelines on Euthanasia, require written scientific justification and must be approved by the IACUC.

Review Procedure

  • AUPs are reviewed by the Office of Research Compliance, the attending veterinarian and the IACUC
  • AUPs may be assigned either designated or full review status
  •  Designated:  Designated review protocols will be assigned an IACUC reviewer.  A five-business-day review period is assigned in which members have the opportunity to review the protocol and to respond to the reviewer if there are concerns.  If no concerns are expressed by committee members or the reviewer, the protocol will be approved and the investigator and facility manager will be notified.  If problems occur or concerns are noted, the protocol will be processed utilizing full committee review.
  •  Full:  Full committee reviews are reviewed and discussed at the monthly IACUC meetings.  Prior to the meeting, two reviewers are assigned to review the protocol and to provide an overview to the committee at the meeting.  The following actions may result:
    • Approve as submitted
    • Withhold approval pending clarifications or modifications
    • Disapprove

The investigator and facility manager will be notified of the review outcome.

Please note:  Animal facility managers are not allowed to purchase, transfer or accept animals for projects until receipt of documented IACUC approval.

Qualifications of Personnel

Regulations in both the PHS Policy and The Animal Welfare Act require that Clemson University provide training for investigators, graduate students and technicians.  Training is offered online with the Collaborative Institutional Training Initiative (CITI) Program.  Additionally, personnel with “significant animal contact” (defined as any contact with animals), must enroll in the Clemson University Medical Surveillance Program.  If you have any questions, contact the IACUC Office at 864-656-4538.

The Animal Welfare Act places responsibility with the IACUC for determining qualifications of individuals involved in animal research, teaching and testing activities.  Qualifications to perform specific procedures will be based on information provided in this section of the AUP.

Graduate students who plan to perform surgery, administer anesthesia or perform euthanasia must document adequate training prior to conducting these procedures.  Investigators and research technicians who are not experienced with animal procedures required by the protocol must schedule individual training through the Office of Animal Resources.  Veterinary technicians and research technicians skilled in performing specific procedures will provide training and provide the IACUC with an assessment of the individuals’ qualifications.

Investigators are responsible for ensuring that all their personnel are trained and that employees implement proper animal procedures.

Applying to NIH?

NIH Office of Extramural Research (OER) has produced a podcast explaining what must be included in your grant application if you use vertebrate animal in your research. The podcast or a transcript can be found at http://grants.nih.gov/grants/oer.htm.

NIH reference guide, "What Investigators Need to Know About the Use of Animals".

The NIH proposal requires information about animal facilities where the work will be performed.  We have created a boilerplate statement to help you respond to this question.