Office of Research

Select Agents/ Toxins and Principles of Laboratory Biosecurity

Select Agents are federally regulated agents that have potential use in biological warfare. Health and Human Services (HHS) regulates select agents targeting humans, the United States Department of Agriculture (USDA) regulates select agents targeting animals, and the USDA Plant Protection and Quarantine (PPQ) regulates select agents targeting plants. Before possessing, using, sending, or receiving select agents, the institution and Principal Investigator must register with CDC, APHIS, and/or USDA to receive official authorization for each individual requesting access to select agents. Requirements include background checks on those authorized to access select agents, security plans and inventories. Immediately notify the BSO if you discover select agents in your laboratory that have not been registered. View the Select Agent/Toxin List here: http://www.selectagents.gov/Select Agents and Toxins List.html 

Anyone desiring to work with these materials must have security clearance to do so and have special security procedures in place for their labs. Investigators wishing to work with any of these agents MUST contact Tami Hemingway (the duly authorized responsible official) prior to doing so, and all security clearances and procedures must be in place prior to requesting the Select Agents (note that requests for Select Agents MUST be placed by the Responsible Official). Contact: Tami Hemingway:  
Phone: 864-656-4084 Fax: 864-656-4475
 E-mail: theming@clemson.edu for assistance with Select Agent requirements.

The term “biosecurity” has multiple definitions. In the animal industry, the term biosecurity relates to the protection of an animal colony from microbial contamination. In some countries, the term biosecurity is used in place of the term biosafety. For the purposes of this section the term “biosecurity” will refer to the protection of microbial agents from loss, theft, diversion or intentional misuse. This is consistent with current WHO and American Biological Safety Association (ABSA) usage of this term.

Biosafety and biosecurity programs share common components. Both are based upon risk assessment and management methodology; personnel expertise and responsibility; control and accountability for research materials including microorganisms and culture stocks; access control elements; material transfer documentation; training; emergency planning; and program management. Biosafety and biosecurity program risk assessments are performed to determine the appropriate levels of controls within each program. Biosafety looks at appropriate laboratory procedures and practices necessary to prevent exposures and occupationally-acquired infections, while biosecurity addresses procedures and practices to ensure that biological materials and relevant sensitive information remain secure.

A detailed discussion of a lab biosecurity program may be viewed at: http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5_sect_VI.pdf

LABS MUST BE KEPT LOCKED WHEN NOT IN USE.


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