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Jeffrey N. Anker

Dr. Jeffrey AnkerWallace R. Roy Distinguished Associate Professor
Analytical Chemistry

Phone: (864) 656-1726
Office: 118 Biosystems Complex (BRC)
Laboratory: 102 BRC
E-mail: janker@clemson.edu

Research Interests | Publications | Editorials and Perspectives | Research Lab

Dr. Anker received his B.S from Yale University and earned his Ph.D. (2005) from The University of Michigan with Prof. Raoul Kopelman working on magnetically modulated fluorescence-based sensors. After graduation, he was an NIH Postdoctoral Fellow at Northwestern University with Prof. Richard Van Duyne, where he developed plasmonics-based nanosensors to measure chemical concentrations and measure binding kinetics. He joined the Clemson faculty in 2008. Dr. Anker is also a member of the Center for Optical Materials Science and Engineering Technologies (COMSET), and Institute of Environmental Toxicology (ENTOX), South Carolina Bioengineering Center for Regeneration and Formation of Tissues (SC BioCRAFT), and Clemson University School of Health Research (CUSHR).

Research Interests

Dr. Anker’s research uses a combination of optical spectroscopy and nanoparticle devices to study chemical and biophysical processes. The interdisciplinary research involves development and bioanalytical application of multifunctional plasmonic and fluorescent sensors and effectors. Fluorescent and plasmonic nanoparticles are increasingly used in cellular imaging because they fluoresce and scatter light so brightly that individual nanoparticles can be easily observed over extended periods. In addition, nanoparticles can act as a platform onto which many components can be loaded. By loading new components onto nanoparticle platforms, new properties are created with diverse applications.  Anker also has been developing sensors to study the chemical environment around implanted medical devices to detect infection, and mechanical sensors to monitor bone healing.  These sensors are read using a X-ray imaging and optical spectroscopy.  More details of the work are given on the lab website.

Publications

1. Chen H., Sulejmanovic D., Moore T., Colvin D.C., Qi B., Mefford O.T., Gore J.C., Alexis F., Hwu S-J., and Anker J.N.: Chemistry of Materials. “Iron-loaded magnetic nanoparticles for pH-triggered drug release and MRI imaging.” (http://dx.doi.org/10.1021/cm404168a, 2014). Selected as an ACS Editor’s Choice.

2. Anker J.N., Koo Y.E.L., and Kopelman R.: “Magnetically Guiding and Orienting Integrated Chemical Sensors.” Journal of Magnetism and Magnetic Materials. DOI: 10.1016/j.jmmm.2014.02.089i. (2014).

3. Moore T., Chen H., Morrison R., Wang F., Anker J.N., and Alexis F.: “Nanotechnologies for Non-invasive Measurement of Drug Release.” Molecular Pharmaceutics. 11, 24-39 (2014).

4. Wang F., Raval Y., Chen H., DesJardins J.D., Tzeng T.-R., and Anker J.N.: "Development of luminescent pH sensor films for monitoring bacterial growth through tissue." Advanced Healthcare Materials, 3, 197-204 (2014).

5. Chen H., Qi B., Moore T., Colvin D.C., Crawford T., Gore J.C., Alexis F., Mefford O.T., and Anker J.N.: "Synthesis of bright PEGylated luminescent magnetic up-conversion nanophosphors for dual MRI and deep tissue imaging." Small, 10, 160-168 (2014).

6. Chen H., Colvin D.C., Qi B., Moore T., He J., Mefford O.T., Alexis F., Gore J.C., Anker J.N.: “Magnetic and optical properties of multifunctional core-shell radioluminescence nanoparticles.” Journal of Materials Chemistry 22, 12802-12809, (2012).

7.  Chen H., Moore T., Qi B., Colvin D.C., Jelen E.K. Hitchcock D., He J., Mefford O.T., Alexis F., Gore J.C., Anker J.N.: “Monitoring pH-triggered Drug Release from Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence.” ACS Nano, http://dx.doi.org/10.1021/nn304369m. (2013). Selected as the article of the month for the ACS Nano Podcast.

8. Underwood C.C., McMillen C.D., Chen H., Anker J.N., and Kolis J.W. “Hydrothermal Chemistry, Structures, and Luminescence Studies of Alkali Hafnium Fluorides.” Inorganic Chemistry, dx.doi.org/10.1021/ic301760a (2012)

8. Wang F., Widejko R.G., Yang Z., Nguyen K.V.T., Chen H, Fernando L.P., Christensen K.A., Anker, J.N.: “Surface-enhanced Raman scattering detection of pH with silica-encapsulated 4-mercaptobenzoic acid-functionalized silver nanoparticles.” Analytical Chemistry. 84, 8013-8019(2012).

10. Chen, H., Rogalski M., Anker, J.N.: “Advances in functional X-ray imaging techniques and contrast agents.” Physical Chemistry Chemical Physics, 14 13469-13486 (2012). Invited Review.

11. Hall, W. P.; Modica, J.; Anker, J.; Lin, Y.; Mrksich, M.; Van Duynet, R. P., A Conformation-and Ion-Sensitive Plasmonic Biosensor. Nano Letters 11 (3), 1098-1105 (2011)

12. Yang Z., Nguyen K.V.T.; Chen H., Qian H.; Fernando L., Christensen K., Anker J.N.  “Plasmonic Silver Nanobelts via Citrate Reduction in the Presence of HCl and their Orientation-Dependent Scattering Properties.” The Journal of Physical Chemistry Letters, 2, 1742-1746, (2011).

13. Chen H., Patrick, A., Yang, Z., VanDerveer D., Anker J.N. “High-resolution chemical imaging through tissue with an X-ray scintillator sensor.” Analytical Chemistry, 83, 5045-5049, (2011).

14. Chen H., Longfield D.E., Varahagiri V.S., Nguyen K.V.T, Patrick A.L., Qiana H.,  VanDerveer D.G., Anker J.N. “Optical imaging in tissue with X-ray excited luminescent sensors.” Analyst, Special Edition on Emerging Investigators 136, 3438-3445 (2011). (Tagged as a hot article in the Analyst blog)

15. Yang Z., Qian H, Chen H, and Anker J.N. “One-pot hydrothermal synthesis of silver nanowires via citrate reduction.” Journal of Colloid and Interface Science 32, 285-291, (2010).

16. Bingham J.M., Anker J.N., Kreno L.E., Van Duyne R.P. “Gas Sensing with High-Resolution Localized Surface Plasmon Resonance Spectroscopy.” Journal of the American Chemical Society. 132, 17358–17359, (2010).

17. Anker J.N., Hall W.P., Lambert M.P., Velasco P.T., Mrksich M., Klein W.L., and Van Duyne R.P.: “Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.” Journal of Physical Chemistry C., 113, 5891-5894 (2009).

18. Biggs K.B., Camden J.P., Anker J.N., and Van Duyne R.P.: "Surface-Enhanced Raman Spectroscopy of Benzenethiol Adsorbed from the Gas Phase onto Silver Film over Nanosphere Surfaces: Determination of the Sticking Probability and Detection Limit Time," Journal of Physical Chemistry A., 113, 4581-4586 (2009).

19. Anker J.N., Hall W.P., Lyandres O., Shah N.C., Zhao J., Van Duyne R.P.: “Biosensing with Plasmonic Nanosensors.” Nature Materials, 7, 442-453 (2008).

20. Hall W.P., Anker J.N., Lin Y., Modica J., Van Duyne R.P., Lin Y., Mrksich M.  “A Calcium-Modulated Plasmonic Switch.” J. Am. Chem. Soc., 18, 5836–5837 (2008).

21. Anker J.N., Koo Y.E., and Kopelman R.: “Magnetically Controlled Sensor Swarms.” Sensors and Actuators B, 121, 83-92, (2007).

22. McNaughton B.H., Stoica V.A., Anker J.N., Tyner K.M., Clarke R.  and Kopelman R.: “Fabrication of Uniform Magnetic Nanoparticles.” Materials Research Society Symposium Proceedings, 899E, 0988-N04-03, (2006).

23. Huang H., Anker J.N., Wang K., and Kopelman R.: “Magnetically Assisted and Accelerated Non-Planar Self-assembly into Strawberry-like Nano/Microparticles.” Journal of Physical Chemistry B, 110, 19929-19934, (2006).

24. McNaughton B.H., Kehbein K., Anker J.N., and Kopelman R.: “A Sudden Breakdown in Linear Response of a Rotationally Driven Magnetic Microparticle and Application to Physical and Chemical Microsensing.” Journal of Physical Chemistry B., 110, 18958-18964, (2006).

25. Lemola K., Ting M., Gupta P., Anker J.N., Chugh A., Good E., Reich S., Tschopp D., Igic P., Elmouchi D., Jongnarangsin K., Bogun F., Pelosi F., Morady F., and Oral H.: “Effects of Two Different Catheter Ablation Techniques on Spectral Characteristics of Atrial Fibrillation.” Journal of American College of Cardiology J.C., 48, 340-348, (2006).

26. Anker J.N., Behrend C.J., McNaughton B.H., Roberts T.G., and Kopelman R..: “Magnetically Modulated Optical Nanoprobes (MagMOONs) and Systems.” Journal of Magnetism and Magnetic Materials, 293, 655-662, (2005).

27. Behrend C.J., Anker J.N., McNaughton B.H., and Kopelman R.: “Microrheology with Modulated Optical Nanoprobes (MOONs).” Journal of Magnetism and Magnetic Materials, 293, 663-670, (2005).

28. McNaughton B.H., Anker J.N., and Kopelman R.: “Magnetic Microdrill as a Modulated Fluorescent pH Sensor.” Journal of Magnetism and Magnetic Materials, 293, 696-701, (2005).

29. Roberts T.G., Anker J.N., and Kopelman R.: “Magnetically Modulated Optical Nanoprobes (MagMOONS) for Detection and Quantification of Biologically Important Ions against the Natural Background Fluorescence of Intracellular Environments.” Journal of Magnetism and Magnetic Materials, 293, 715-724, (2005).

30. Agayan R.R., Horvath T., McNaughton B.H., Anker, J.N., and Kopelman R.: “Optical Manipulation of Metal-Silica Hybrid Nanoparticles.” Proc. SPIE. Int. Soc. Opt. Eng., 5514, 502-513, (2004).

31. Anker J.N., Behrend C.J., McNaughton B.H., Roberts T.G., Brasuel M., Philbert M.A., and Kopelman R.: “Characterization and Applications of Modulated Optical Nanoprobes (MOONs).” Materials Research Society Symposium Proceedings, 790, 4.4.1-12, (2004).*

32. Behrend C.J., Anker J.N., McNaughton B.H., Roberts T.G., Brasuel M., Philbert M.A., and Kopelman R.: “Metal-Capped Brownain and Magnetically Modulated Optical Nanoprobes (MOONs): Micromechanics in Chemical and Biological Microenvironments.” Journal of Physical Chemistry B, 108,10408-10414,(2004).

33. Behrend C.J., Anker J.N., and Kopelman, R.: “Brownian Modulated Optical Nanoprobes.” Applied Physics Letters, 84, 154-156, (2004).

34. Yan F., Xu H., Anker J.N., Kopelman R., Ross B., Rehemtulla A., and Reddy R.: “Synthesis and Characterization of Silica-Embedded Iron Oxide Nanoparticles for Magnetic Resonance Imaging.” Journal of Nanoscience and Nanotechnology, 4, 72-76, (2004). 

35. Anker J.N. and Kopelman R.: “Magnetically Modulated Optical Nanoprobes.” Applied Physics Letters, 82, 1102-1104, (2003).

31. Anker J.N., Behrend C.J., and Kopelman R.: Aspherical Magnetically Modulated Optical Nanoprobes.” Journal of Applied Physics, 93, 6698-6700, (2003).

36. Anker J.N., Horvath T. D., and Kopelman R.: “Cooking With Nanoparticles: A Simple Method of Forming Pancake, Roll, and Breaded Polystyrene Microparticles.” European Cells and Materials, 3, 95-97, (2002).

Editorials and Perspectives

1. Rogalski M.M., Nguyen K.V.T., and Anker J.N.: “X-ray Vision for Molecules,” The Briefing. Invited Perspective. (2013). http://the-briefing.com/x-ray-vision-for-molecules/

2. Alexis F, Anker J.N.: “Theranostic nanotechnologies: moving beyond imaging the localization of the drug.” Future Science. 5, 97-100 (2014). Invited Editorial.

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