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R. Kenneth Marcus

Dr. R. Kenneth MarcusUniversity Professor
Analytical Chemistry

Phone: (864) 656-5011
Office: 106 Biosystems Research Complex
E-mail: marcusr@clemson.edu

  

Ken Marcus ice-bucket challenge 

Research Interests | Publications | Research Group

Dr. Marcus earned B.S. degrees (1982) in chemistry and physics from Longwood College and a Ph.D. (1986) in analytical chemistry from the University of Virginia. He serves on the editorial advisory board for three international journals and was the recipient of the 2001 S.C. Governor¹s Award for Excellence in Science Research. In 2010, Professor Marcus was named a Fellow of the Royal Society of Chemistry (FRSC), in 2012 a Fellow of the American Association for the Advancement of Science (FAAAS), and in 2016 a Fellow of the Society for Applied Spectroscopy.

Research Interests

The development and application of new plasma techniques for the atomic spectroscopic analysis of diverse materials is a major focus of this research group.  Included in this work is the design of atomic emission and mass spectrometry instrumentation employing glow discharge (GD) sources.  Instrumentation developed in the Marcus laboratory is now commercially available from a number of manufacturers.  Current efforts are directed at the development of the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma as a spectrochemical source for optical emission and mass spectrometric analysis.  The sources are being developed in efforts to affect field deployable platforms for applications in the nuclear nonproliferation and nuclear safeguards arenas.  Current funding comes from DTRA and the NNSA through the Pacific Northwest National Laboratory.  A continuing area of emphasis has been the development of novel detection methods for liquid chromatography.    The most recent area of liquid chromatography development is a class of polymer fibers as stationary phases for analytical and preparative scale separations of proteins.  These capillary-channeled polymer (C-CP) fibers can be extruded from simple commodity polymers, including polypropylene, polyester, and nylon.   In their native states, the fibers can affect separations in reversed phase, ion exchange, and hydrophobic interation modes.  Extensive efforts are directed at the development of straight forward, on-column, surface modification chemistries that add selectivity to the excellent mass transport properties of C-CP fiber columns.   Chromatography funding comes from the NSF.  Marcus has been on the Clemson faculty for 30 years, graduating 34 Ph.D. and 10 MS students.  He holds over a dozen patents, serves on the editorial advisory board of three scientific journals, and is a Fellow of the Royal Society of Chemistry, the American Association for the Advancement of Science, and the Society for Applied Spectroscopy.

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Publications

Liuwei Jiang and R. Kenneth Marcus, "Microwave-assisted grafting polymerization modification of nylon 6 capillary-channeled polymer fibers for enhanced weak cation exchange protein separations", Anal. Chim. Acta, 954, 129-139, 2017.

R. Kenneth Marcus, Benjamin T. Manard, and C. Derrick Quarles, Jr., "Liquid Sampling - Atmospheric Pressure Glow Discharge (LS-APGD) Microplasmas for Diverse Spectrochemical Analysis Applications", J. Anal. At. Spectrom., 32, 704-716, 2017.

Htoo W. Paing and R. Kenneth Marcus, "Parametric Evaluation of Ambient Desorption Optical Emission Spectroscopy Utilizing a Liquid Sampling-Atmospheric Pressure Glow Discharge Microplasma", J. Anal. At. Spectrom., 32, 931-941, 2017.

Liuwei Jiang and R. Kenneth Marcus, "Microwave-assisted, grafting polymerization preparation of strong cation exchange nylon 6 capillary-channeled polymer fibers and their chromatographic properties", Anal. Chim. Acta, 977, 52-64, 2017.

Hung K. Trang and R. Kenneth Marcus, "Application of protein A-modified capillary-channeled polymer polypropylene fibers to the quantitation of IgG in complex matrices", J. Pharm. Biomed. Anal., 142, 49-58, 2017.

Lynn X. Zhang and R. Kenneth Marcus, “Mass Spectra of Diverse Organic Species Utilizing the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Microplasma Ionization Source”, J. Anal. At. Spectrom., 31, 145-151, 2016.

R. Kenneth Marcus and Antje J. Baeumner, “Fiber-based platforms for bioanalytics”, Anal. Bioanal. Chem. 408, 1281-1283, 2016.

Liuwei Jiang and R. Kenneth Marcus, “Comparison of Analytical Protein Separation Characteristics for Three Amine-Based Capillary-Channeled Polymer (C-CP) Stationary Phases”, Anal. Bioanal. Chem., 408, 1373-1383, 2016.

Lynn X. Zhang, Liuwei Jiang, Daniel R. Willett and R. Kenneth Marcus, “Parallel, Open-Channel Lateral Flow (Immuno) Assay Substrate Based on Capillary-Channeled Polymer Films”, Analyst, 141, 807-814, 2016.

Hung K. Trang, Abby J. Schadock-Hewitt, Liuwei Jiang and R. Kenneth Marcus, “Evaluation of loading characteristics and IgG binding performance of Staphylococcal Protein A on polypropylene capillary-channeled polymer fibers”, J. Chromatogr. B, 1015, 92-104, 2016.

Lynn X. Zhang, Carolyn Q. Burdette, Melissa M. Phillips, Catherine A. Rimmer, and R. Kenneth Marcus, “Determination of Isoflavone Content in SRM 3238 Using Liquid Chromatography-Particle Beam/Electron Ionization Mass Spectrometry”, J. AOAC Int., 98, 1483-1490, 2015.

Abby J. Schadock-Hewitt, and R. Kenneth Marcus, “Evidence for the Intercalation of PEG-Lipid Acyl Chains into Polypropylene Fiber Matrices”, Langmuir, 31, 10418−10425, 2015.

Liuwei Jiang, Yi Jin, and R. Kenneth Marcus, “Polyethylenimine Modified Poly(ethylene terephthalate) Capillary Channeled-Polymer (C-CP) Fibers for Anion Exchange Chromatography of Proteins”, J. Chromatogr. A, 1410, 200-209, 2015.

Lynn X. Zhang, Benjamin T. Manard, Brian A. Powell, and R. Kenneth Marcus, “Preliminary Assessment of Potential for Metal-Ligand Speciation in Aqueous Solution via the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Ionization Source: Uranyl Acetate”, Anal. Chem., 87, 7218-7225, 2015.

Benjamin T. Manard, Sarah M. H. Jones, and R. Kenneth Marcus, “Capillary-Channeled Polymer (C-CP) Fibers for the Rapid Extraction of Proteins from Urine Matrices Prior to Detection with MALDI-MS”, Proteomics-Clinical Applications, 9, 522-530, 2015.

Zhengxin Wang and R. Kenneth Marcus, “Roles of Interstitial Fraction and Load Linear Velocity on the Dynamic Biding Capacity of Proteins on Capillary Channeled Polymer Fiber Columns”, Biotechnol. Prog., 31, 97-109, 2015.

Liuwei Jiang, Abby J. Schadock-Hewitt, Lynn X. Zhang and R. Kenneth Marcus, “Synthesis and Characterization of Lipid Tethered Ligands for Surface Functionalization of Polypropylene Capillary-Channeled Polymer Fiber Stationary Phase”, Analyst, 140, 1523-1534, 2015.

Liuwei Jiang and R. Kenneth Marcus, “Biotin functionalized poly(ethylene terephthalate) capillary-channeled polymer fibers as HPLC stationary phase for affinity chromatography”, Anal. Bioanal. Chem., 407, 939-951, 2015.

Benjamin T. Manard, Stefanie Konegger-Kappel, Jhanis J. Gonzalez, Jose Chirinos, Meirong Dong, Xianglei Mao, R. Kenneth Marcus*, and Richard E. Russo, Liquid Sampling-Atmospheric Pressure Glow Discharge as a Secondary Excitation Source for Laser Ablation-Generated Aerosols: Parametric Dependences and Robustness to Particle Loading”, Appl. Spectrosc., 69, 58-66, 2015.

Stefanie Konegger-Kappel, Benjamin T. Manard, Lynn X. Zhang, Thomas Konegger, and R. Kenneth Marcus, “Liquid Sampling–Atmospheric Pressure Glow Discharge Excitation of Atomic and Ionic Species”, J. Anal. At. Spectrom., 30, 285-295, 2015.

Lynn X. Zhang, Benjamin T. Manard, R. Kenneth Marcus, “Evaluation of the Operating Parameters of the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Ionization Source for Elemental Mass Spectrometry”, Anal. Bioanal. Chem., 406, 7497–7509, 2014.

Abby J. Schadock-Hewitt and R. Kenneth Marcus, “Loading characteristics and chemical stability of head group-functionalized PEG-lipid ligand tethers on polypropylene capillary-channeled polymer fibers”, J. Sep. Sci., 37, 3595-3602, 2014.

Benjamin T. Manard, Jhanis J. Gonzalez, Arnab Sarkar, Xianglei Mao, Lynn X. Zhang, Stefanie Konneger-Kappel, R. Kenneth Marcus, and Richard E. Russo, “Investigation of Spectrochemical Matrix Effects in the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Source”, Spectrochim. Acta, Part B, 100, 44-51, 2014.

Benjamin T. Manard, Jhanis J. Gonzalez, Arnab Sarkar, Xianglei Mao, Lynn X. Zhang, Stefanie Konneger-Kappel, R. Kenneth Marcus, and Richard E. Russo, “Investigation of Spectrochemical Matrix Effects in the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Source”, Spectrochim. Acta, Part B, 100, 44-51, 2014.

Benjamin T. Manard, Jhanis J. Gonzalez, Arnab Sarkar, Xianglei Mao, Lynn X. Zhang, Stefanie Konneger-Kappel, R. Kenneth Marcus, and Richard E. Russo, “Investigation of Spectrochemical Matrix Effects in the Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Source”, Spectrochim. Acta, Part B, 100, 44-51, 2014.

Zhengxin Wang and R. Kenneth Marcus, “Determination of Pore Size Distributions in Capillary-Channeled Polymer (C-CP) Fiber Stationary Phases by Inverse Size-Exclusion Chromatography (iSEC) and Implications for Fast Protein Separations”, J. Chromatogr. A, 1351, 82-89, 2014.

Benjamin T. Manard, Jhanis J Gonzalez, Arnab Sarkar, Meirong Dong, Jose R. Chirinos, Xianglei Mao, Richard E. Russo, and R. Kenneth Marcus, “Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) as a Secondary Excitation Source: Assessment of Plasma Characteristics”, Spectrochim. Acta, Part B, 94, 39-47, 2014.

Abby J. Schadock-Hewitt and R. Kenneth Marcus, “Initial Evaluation of Protein A-Modified Capillary-Channeled Polymer Fibers for the Capture and Recovery of Immunoglobulin G”, J. Sep. Sci., 37, 495-504, 2014.

Abby J. Schadock-Hewitt, Jennifer J. Pittman, Kenneth A. Christensen, and R. Kenneth Marcus, “Head Group-Modified Lipid Surface Modification for Highly Selective Analyte Extractions on Capillary-Channeled Polymer (C-CP) Fibers”, Analyst, 139, 2108-2113, 2014.

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