Clemson University 's Institute of Environmental Toxicology (CIET) is a community of faculty, staff, and students who have dedicated themselves to determining solutions to complex toxicological problems.  The Institute is housed in a 38,000 square foot research facility in Pendleton, South Carolina . Just ten minutes from the Clemson campus, CIET contains office space and state-of-the-art laboratories for its  faculty and graduate students. Many of the laboratories have computer-controlled environments and there are specialized testing rooms. These testing rooms are dedicated laboratories used for exposures, isolations, histopathology, and analysis of chemicals in a variety of matrices. The Institute's on-site Animal Care Facility is accredited by The American Association for the Accreditation of Laboratory Animal Care (AAALAC). A recent addition is the Ecoclinical Microbiology Laboratory, which supports the Antimicrobial Resistance Program. Research activities at CIET encompass the areas of aquatic ecotoxicology, biochemical and molecular toxicology, immunobiology and immunotoxicology, development of antimicrobial resistance in populations, terrestrial ecotoxicology, analytical chemistry, and ecological modeling. A strong fundamental research program at IET examines the mechanisms of how chemicals exert their toxicity and how variability in individual organisms can lead to sensitivity or resistance in a wide array of species. Methods developed from research studies provide the means for assessing chemical exposure and impact natural and man-made enviroments. Field studies, used to document the status of potentially affected species, typically incorporate small mammal and avian habitat assessment, water and vegetation sampling and collection of invertebrates and aquatic organisms and estuarine-marine habitat assessment. Data acquired are often incorporated into ecological modeling systems to predict the effects of toxicants on ecosystems. Computer simulations are then constructed to formulate and analyze different experiments and to search for optimal solutions for risk management. Data acquired from field studies are integrated with laboratory findings to provide real-world evidence in the quest to determine biological responses to substance exposure.