Genetics and Biochemistry

Dr. Meredith Morris

Meredith Morris

Assistant Professor

Ph.D. Biochemistry and Molecular Biology
2000, University of Georgia

Contact Information
Office: 251B Life Sciences Building
Phone: (864) 656-0367
Email: mmorri3@clemson.edu

Research Focus Areas
Molecular Parasitology

 

Research Activities

Trypanosoma brucei  (T. brucei) is a protozoan parasite, which causes Human African Trypanosomiasis and nagana, a wasting disease in livestock.  T. brucei has a unique metabolism whose requirements are met by unique, dynamic organelles named glycosomes.  My research focuses on identifying pathways involved in the maintenance and proliferation of these organelles, which are essential and unique to the parasite.  Understanding these mechanisms will lead to the identification of new parasite-specific therapeutic targets.

 

Graduate Students

 

Undergraduates

Elizabeth Kahney

Courses Taught

GEN 3000
Molecular and General Genetics

BCHM 4230
Principles of Biochemistry

BCHM 4930
Senior Seminar

Resources

 

Recent Publications

Morris, M.T., Dodson, H.C., and Morris,J.C. (In preparation). Environment-dependent regulation of glycosome protein composition in the African trypanosome.

Dodson, H.C., Morris, M.T., Morris, J.C. Glycerol-3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental change. J Biol Chem. 2011 Aug 3. [Epub ahead of print]

Coley, A.F., Dodson, H.C., Morris, M.T.,Morris, J.C.  Glycolysis in the African Trypanosome: Targeting Enzymes and Their Subcellular Compartments for Therapeutic Development. Molecular Biology International, Volume 2011 (2011), Article ID 123702,  doi:10.4061/2011/123702

Sharlow, E. R., Lyda, T. A., Dodson, H. Cl, Mustata, G., Morris, M. T., Leimgruber, S. S., Lee, K., Kashiwada, Y., Close, D., Lazo, J. S., Morris, J. C. (2010) A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLOS Neglected Tropical Diseases, 4 (4) e659 doi:10.1371/journal.pntd.0000659

Clemmens, S., Morris, M. T., Lyda, T. A., Acosta-Serrano, A. Morris, J.C. (2009), “Trypanosoma brucei AMP-activated kinase subunit homologs influence surface molecule expression.” Experimental Parasitology, doi:j.exppara.2009.07.010

Chambers, J. W., Morris, M. T., Smith, K., Morris. J. C. (2008). "Residues in an ATP binding domain influence sugar binding in a trypanosome hexokinase." Biochem Biophys Res Commun 365(3): 420-5.

Chambers, J. W., Kearns, M., Morris, M. T., Morris, J. C. (2008). "Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme." J Biol Chem 283(22): 14963-70.

Chambers, J. W., Fowler, M., Morris, M. T., Morris, J. C. (2008). "The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1." Mol Biochem Parasitol 158(2): 202-7.

Morris, JC, Morris, M.T., Lee, SY, Toole, WP, Seifert, CM, and Acosta-Serrano, A. (2007) Chapter 3 Reverse and forward genetics as practical approaches for post-genome studies. In: Barry, D., Mottram, J., McCulloch, R., Acosta-Serrano, A., eds. Trypanosomes -After the Genome. Horizon Bioscience. 49-70.

Morris, M. T., C. DeBruin, et al. (2006). "Activity of a second Trypanosoma brucei hexokinase is controlled by an 18-amino-acid C-terminal tail." Eukaryot Cell 5(12): 2014-23.