Genetics and Biochemistry

Dr. Michael Sehorn

Michael Sehorn

Associate Professor

Ph.D. Biochemistry and Molecular Biology
2002, Lousiana State University

Contact Information
Office: 057A Life Sciences Building
Phone: (864) 656-2572
Email: msehorn@clemson.edu

Research Focus Areas
Protein Biochemistry
Structure-Function Relations

 

Research Activities

Sexual reproduction is dependent upon a specialized type of cell division called meiosis. Early in meiosis, homologous chromosomes pair with each other and are physically linked together by recombination. Linkage of the homologous chromosomes is critical for proper segregation of the chromosomes to opposites poles in the cell. Our research is focused on the mechanism of recombination during meiosis.

 

Grant Support

 

Awards

2011 Clemson University College of Agriculture, Forestry, and Life Sciences Teaching Award of Excellence

2011 Article Selected for Cover Art in journal Macromolecular Bioscience

 

Research Associates

 

Graduate Students

 

Undergraduate Students

Ian Alvey
John Diehl
Austin Herbst
Austin Hughes
Erin Ratterman
Leah Watts
Julie White

 

Courses Taught

BCHM 3050
Essential Elements of Biochemistry

BCHM 4360/6360
Nucleic Acids and Protein Synthesis

BCHM 8140
Advanced Biochemistry

Resources

 

Recent Publications

McKee, J.R., McKee, T., Sehorn, M.G. (2011) “Student Study Guide/Solutions Manual for use with Biochemistry The Molecular Basis of Life, Fifth Edition.” Oxford University Press.

Gaines, W.A., Sehorn, M.G., Marcotte, W.R. Jr. (2010) Spidroin N-terminal domain promotes a pH-dependent association of silk proteins during self-assembly. J. Biol. Chem. 285(52):40745-53.

Rungta, P., Bandera, Y.P., Roeder, R.D., Li, Y., Baldwin, W.S., Sharma, D., Sehorn, M.G., Luzinov, I., Foulger, S.H. (2011) Selective Imaging and Killing of Cancer Cells with Protein Activated Near-Infrared Fluorescing Nanoparticles. Macromol Biosci. 11(7):927-37.
**Selected for cover art of the Journal**

Say, A. F., Ledford, L.A., Sharma, D., Singh, A.K., Leung, W.K., Sehorn, H.A., Tsubouchi, H., Sung, P., Sehorn, M.G. (2011) The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure. DNA Repair. 10(6):586-94.

Sehorn, M.G., Sehorn, H. A. (2011) Visualization of human Dmc1 presynaptic filaments. Methods Mol. Biol. 745:485-96.

Chi, P., Kwon, Y., Moses, D. N., Seong, C., Sehorn, M.G., Singh, A.K., Tsubouchi, H., Greene, E.C., Klein, H.L., Sung, P. (2009) Functional Interactions of Meiotic Recombination Factors Rdh54 and Dmc1. DNA Repair 8(2):279-84.

Sheridan, S. D., Yu, X., Roth, R., Heuser, J.E., Sehorn, M.G., Sung, P., Egelman, E.H., Bishop, D.K. (2008) A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments. Nucleic Acids Res. 36(12):4057-66.

Busygina, V., Sehorn, M.G., Shi, I., Tsubouchi, H., Roeder, S., Sung, P. (2008) Hed1 regulates Rad51-mediated recombination via a novel mechanism. Genes Dev. 22(6):786-95.

Seong, C., Sehorn, M.G., Plate, I., Shi, I., Song, B., Chi, P, Mortensen, U., Sung, P., and Krejci, L. (2008) Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52. J. Biol. Chem. 283(18):12166-74.

Hu, Y., Raynard, S., Sehorn, M.G., Lu, X., Bussen, W., Zheng, L., Stark, J.M., Barnes, E.L., Chi, P., Janscak, P., Jasin, M., Vogel, H., Sung, P., Luo, G. (2007) RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev. 21(23):3073-84.

Chi, P., San Filippo, J., Sehorn, M.G., Petukhova, G. V., Sung P. (2007) Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. Genes Dev. 21(14):1747-57.