Genetics and Biochemistry

Dr. Stephen Kresovich

Stephen Kresovich

The Robert and Lois Coker Trustees Chair of Genetics/ SmartState Chair of Genomics

Ph.D. Agronomy (Physiology and Genetics)
The Ohio State University

Contact Information
Office: 318 Biosystems Research Complex
Phone: (864) 656-1194
Email: skresov@clemson.edu

Research Focus Areas
Plant Genetics and Biochemistry
Genomics, Bioinformatics and Population Genetics

 

Research Activities

Over the past two decades, tremendous progress has been made to advance our understanding of crop genome organization, variation, and evolution, particularly as it relates to potential discovery and exploitation of useful genic or genotypic diversity in plants.  Critical to this progress has been advances in molecular biology/genetics, genomics, as well as thoughtful applications of the theories of evolutionary biology and plant breeding.  It is well recognized that a crop genome is a dynamic unit whose organization and variation has been molded by evolutionary processes and human intervention.

My research objectives are: (1) to identify regions of the sorghum, sugar cane, and maize genomes which have been fixed through evolution, domestication, or crop improvement and associate these selective sweeps with useful types and traits, (2) to characterize and understand the relationship between DNA sequence variation and desirable phenotypes, (3) to identify both conserved sequences across grass/grain families and genera and rapidly evolving sequences between species and individuals to predict gene diversity and function, (4) to characterize molecular diversity of sorghum, sugar cane, and maize in natural populations, landraces, and elite germplasm, and (5) to develop and test strategies to efficiently discover, conserve, and use variation in natural populations and genebank collections by integrating current advances in genomics, bioinformatics, and plant genetics/breeding.

 

Grant Support

North Carolina Biotechnology Center
Sorghum Tools

United Sorghum Checkoff Program
Sorghum Breeding and Genetics for the Southeastern U.S.

NIFA, USDA
Genomic and Breeding Foundations for Cellulosic Sorghum Bioenergy Hybrids

National Science Foundation
Developing an Integrated Platform, Pipeline, and Analytical Tools for Next Generation Genotyping to Serve Breeding Efforts in Africa

 

Awards

Outstanding manuscript on “Plant Genetic Resources”, Crop Science, 2011

Fellow, Crop Science Society of America, 1996

Fellow, American Association for the Advancement of Science, 1995

 

Resources

 

Recent Publications

Morris, G.P., D.H. Rhodes, Z. Brenton, P. Ramu, V.M. Thayil, S. Deshpande, C.T. Hash, C. Acharya, S.E. Mitchell, E.S. Buckler, J. Yu, and S. Kresovich.. Accepted. Dissecting genome-wide association signals for loss-of-function phenotypes in sorghum flavonoid pigmentation traits. Genes, Genomes, and Genetics.

Morris, G.P., P. Ramu, S.P. Deshpande, C.T. Hash, T. Shah, H.D. Upadhyaya, O. Riera-Lizarazu, P.J. Brown, C.B. Acharya, S.E. Mitchell, J. Harriman, J.C. Glaubitz, E.S. Buckler, and S. Kresovich. 2013. Population genomic and genome-wide association studies of agroclimatic traits in sorghum. Proc Natl Acad Sci USA. 110: 453-458.

Kimber, C.T., J.A. Dahlberg, and S. Kresovich. 2012. The genepool of Sorghum bicolor and its improvement. In: Genetics and Genomics of the Saccharinae, pp. 23-42. A.H. Paterson, ed., Springer.

Kump, K.L., P.J. Bradbury, R.J. Wisser, E.S. Buckler, A.R. Belcher, M.A. Oropeza-Rosas, J.C. Zwonitzer, S. Kresovich, M.D. McMullen, D. Ware, P.J. Balint-Kurti, and J.B. Holland. 2011. Genome-wide association study of quantitative resistance to southern leaf blight in the maize nested association mapping population. Nat. Genet. 43:163-169.

Brown, P.J., S. Myles, and S. Kresovich. 2011. The genetic basis of racial classification in sorghum. Crop Sci. 51:224-230.

McMullen, M.D., S. Kresovich, et al. 2009. Genetic properties of the maize nested association mapping population. Science 325:737-740.

Buckler, E.S., J.B. Holland, et al. 2009. The genetic architecture of maize flowering time. Science 325:714-718.

Murray, S.C., W.L. Rooney, S.E. Mitchell, and S Kresovich. 2009. Sweet sorghum diversity and association mapping for plant carbohydrate yield partitioning. Plant Genome 2:48-62.

Pressoir, G.H., P.J. Brown, W.Y. Zhu, N. Upadyayula, T. Rocheford, E.S. Buckler, and S. Kresovich. 2009. Natural variation in maize architecture is mediated by allelic differences at the PINOID co-ortholog barren inflorescence 2. Plant Journal 58:618-628.

Paterson, A.H., et al. 2009. The Sorghum bicolor genome and the diversification of grasses. Nature 457:551-556.