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Biophysicists seek to apply the principles of physics and chemistry and the methods of mathematical analysis and computer modeling to pertinent questions in biology and medicine. Biophysics is predominantly a molecular science, and much effort in the field is directed towards determining the structures and physical properties of specific biological molecules and the larger structures into which they assemble. With the progress made in sequencing the human genome, these efforts are nowadays aimed toward large scale experimental and computational studies of complete metabolic networks. The Biophysics group in the Department of Physics and Astronomy at Clemson University is comprised of researchers with diverse interests spanning from computational theory to experimental biophysics and soft matter.

Biophysics Group Photo

Computational Biophysics and Bioinformatics Laboratory – PI: Emil Alexov, PhD

Computational Biophysics and Bioinformatics at Clemson University investigates putative protein-protein interactions and the structures of these complexes on a genome-scale, thus providing the necessary basics for structure-guided drug design.Computational Biophysics and Bioinformatics Poster

Alper Lab – PI: Joshua Alper, PhD

The Alper Lab uses high-resolution experiments and models to study the physical principles that underlie cell biological systems, particularly the cilia and flagella of eukaryotic organisms.Molecular and Cellular Biophysics Poster

Structure, Dynamics, and Function of Biomolecules Laboratory – PI: Feng Ding, PhD

The Ding research lab focus on understanding the relationship between structure, dynamics, and function of biomolecules and molecular complexes, which can help better understand biology and subsequently find applications in biomedical research. Structure, Dynamics, and Function of Biomolecules Laboratory Poster

Nano-Bio Lab - PI: Ramakrishna Podila, PhD

The research interests of nano-bio lab lie at the interface of physics, biology, and nanoscience. This lab aims to seamlessly integrate the principles of condensed matter physics, optical spectroscopy, and physiological chemistry to elucidate biophysics at the nanoscale.Venn diagram showing the overlap of bio-sensing, nanomedicine, and nanotoxicity.

Single-molecule Biophysics Laboratory – PI: Hugo Sanabria, PhD

The experimental program combines various fluorescence tools at ensemble and single molecule to address the mechanisms of which enzyme, proteins, and signaling molecules function and to study the biophysical properties of biomolecules (e.g. signaling molecules involved in learning and memory, and those associated with neurodegenerative disease) from the nano to the macro scale. The goal is to understand how biomolecules interact, store and transfer information in order to determine the principles underlying biomolecular structure and dynamics and how they relate to their function. Single-Molecule Laboratory Poster