R. Kenneth Marcus
Professor
Analytical Chemistry
Phone: (864) 656-5011
Office: 106 Biosystems Research Complex
E-mail: marcusr@clemson.edu
Research Interests | Publications | Research Group
Dr. Marcus earned B.S. degrees (1982) in chemistry and physics from Longwood College and a Ph.D. (1986) in analytical chemistry from the University of Virginia. He serves on the editorial advisory board for four international journals and was the recipient of the 2001 S.C. Governor¹s Award for Excellence in Science Research. In 2010, Professor Marcus was named a Fellow of the Royal Society of Chemistry (FRSC).
Research Interests
The development and application of new plasma techniques for the atomic spectroscopic analysis of diverse materials is a major focus of this research group. Included in this work is the design of atomic emission and mass spectrometry instrumentation employing glow discharge (GD) sources. Plasma sources have been developed for the analysis of electronic grade materials, polymers and a variety of layered systems. Instrumentation developed in the Marcus laboratory is now commercially available from a number of manufacturers.
A continuing area of emphasis has been the development of novel detection methods for liquid chromatography. Low-pressure plasma sources provide unambiguous molecular and elemental analysis information, which is vital for biological systems regarding the essential and toxic character of different metal species. A recent development has been the use of a low lower atmospheric pressure plasma for the sampling of capillary separations. This plasma offers excellent absolute sensitivities on a platform that is readily employed with lab-on-a-chip experiments. The most recent area of liquid chromatography development is a new class of channeled-polymer fibers as stationary phases, providing very efficient solution flow along with high surface areas.
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Publications
Jennifer J. Pittman, Paul J. Kowalski, and R. Kenneth Marcus, “Capillary-Channeled Polymer (C-CP) Films as Processing Platforms for Protein Analysis by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI-MS)”, J. Am. Soc. Mass Spectrom. 23, 102-107, 2012.
C. Derrick Quarles, Jr., Anthony J. Carado, Charles J. Barinaga, and David W. Koppenaal, R. Kenneth Marcus, “Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Ionization Source for Elemental Mass Spectrometry: Preliminary Parametric Evaluation and Figures of Merit”, Anal. Bioanal. Chem. 402, 261-268, 2012.
R. Kenneth Marcus, C. Derrick Quarles, Jr., Charles J. Barinaga, Anthony J. Carado, and David W. Koppenaal, “Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Ionization Source for Elemental Mass Spectrometry”, Anal. Chem. 83, 2425–2429, 2011.
C. Derrick Quarles, Jr., R. Kenneth Marcus, and Julia L. Brumaghim, “Competitive Binding of Cr3+, Fe3+, and Ni2+ to Transferrin”, J. Biol. Inorg. Chem. 16, 913-921, 2011.
C. Derrick Quarles Jr., K. Manoj Randunu, Julia L. Brumaghim, R. Kenneth Marcus, “Metal Retention in Human Transferrin: Consequences of Solvent Composition in Analytical Sample Preparation Methods”, Metallomics 3, 1027-1034, 2011.
Brad Winn, C. Derrick Quarles, Jr., R. Kenneth Marcus and Martine LaBerge, “Nickel Ions Inhibit α-actin Expression and Decrease Aspect Ratio of Rat Vascular Smooth Muscle Cells in vitro”, Metallomics, 3, 934-940, 2011.
C. Derrick Quarles Jr., Julia L. Brumaghim, and R. Kenneth Marcus, "Instrumental Comparison of the Determination of Cr3+ Uptake by Human Transferrin", Metallomics 2, 792-799, 2010.
Joaudimir Castro, C. Derrick Quarles Jr. and R. Kenneth Marcus, “Ion Source Geometries and Mass Analyzers in Glow Discharge Mass Spectrometry”, in The Encyclopedia of Mass Spectrometry, Vol 5, Elemental and Isotope Ratio Mass Spectrometry D. Beauchemin and D. E. Matthews Eds. (Gross, M. L. and Caprioli, R. M., series eds), Elsevier, 2010, 311-322.
C. Derrick Quarles Jr., Joaudimir Castro and R. Kenneth Marcus, “Glow Discharge Mass Spectrometry”, in The Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition, J. Lindon, G. Tanter, and D. Koppenaal, Eds., Elsevier, 2010, 762-769.
Christine M. Straut and R. Kenneth Marcus, “Small Molecule Adsorption on to Polyester Capillary-Channeled Polymer (C-CP) Fibers: Frontal Analysis of Naphthalene and Naphthol”, J. Sep. Sci. 33, 46-60, 2010.
C. Derrick Quarles Jr., Julia L. Brumaghim, and R. Kenneth Marcus, “Simultaneous Multiple Element Detection by Particle Beam/Hollow Cathode-Optical Emission Spectroscopy as a Tool for Metallomic Studies: Determinations of Metal Binding with Apo-Transferrin”, Metallomics 2, 154–161, 2010.
Joaudimir Castro, M. V. Balarama Krishna, John Choiniere and R. Kenneth Marcus, “Analysis of Caffeic Acid Derivatives in Echinacea Extracts by Liquid Chromatography Particle Beam Mass Spectrometry (LC-PB/MS) Employing Electron Impact and Glow Discharge Ionization Sources”, Anal. Bioanal. Chem. 397, 1259–1271, 2010.
Jennifer J. Pittman, Viktor Klep, Igor Luzinov, and R. Kenneth Marcus, “Extraction of Metals from Aqueous Systems Employing Capillary-Channeled Polymer (C-CP) Fibers Modified with Poly(acrylic acid) (PAA)”, Anal. Methods 2, 461-469, 2010.
Ward A. Burgess, Jennifer J. Pittman, R. Kenneth Marcus, and Mark C. Thies, "Structural Identification of the Monomeric Constituents of Petroleum Pitch", Energy & Fuels 24, 4301-4311, 2010.
Joaudimir Castro, Tara Pregibon, Kristina Chumanov and R. Kenneth Marcus, “Determination of Catechins and Caffeine in Proposed Green Tea Standard Reference Materials by Liquid Chromatography-Particle Beam/Electron Ionization Mass Spectrometry (LC-PB/EIMS)”, Talanta 82, 1687-1695, 2010.
C. Derrick Quarles Jr. and R. Kenneth Marcus, “Conversion of a Commercial Gas Chromatography-Mass Spectrometer to a Liquid Chromatography-Particle Beam/Glow Discharge-Mass Spectrometer”, J. Anal. At. Spectrom. 25, 1780-1786, 2010.
Katie J. Hilbert and R. Kenneth Marcus, “Separation of Water Soluble Polymers using Capillary-Channeled Polymer (C-CP) Fiber Stationary Phases”, J. Sep. Sci. 33, 3571-3577, 2010.
Joaudimir Castro, M.V. Balarama Krishna and R. Kenneth Marcus, “A Liquid Chromatography-Particle Beam Electron Ionization Mass Spectrometry Method for the Analysis of Botanical Extracts: Evaluation of Ephedrine Alkaloids in Standard Reference Materials”, J. AOAC 93, 1788-1797, 2010.
Rayman D.Stanelle and R. Kenneth Marcus, “Nylon-6 Capillary-Channeled Polymer Fibers as a Hydrophobic Interaction Chromatography Stationary Phase for the Separation of Proteins”, Anal. Bional. Chem. 393, 273-281, 2009.
M. V. Balarama Krishna, Joaudimir Castro, Tim M. Brewer and R. Kenneth Marcus, “On-line Separation and Identification of Inorganic and Organic Arsenic Species in Ethanolic Kelp and Bladderwrack Extracts Through Liquid Chromatography/Particle Beam-Electron Ionization Mass Spectrometry (LC/PB-EIMS), J. Anal. At. Spectrom. 24, 199-208, 2009.
R. Kenneth Marcus, “Use of Polymer Fiber Stationary Phases for Liquid Chromatography Separations: Part II - Applications (an invited review) ”, J. Sep. Sci. 32, 695-705, 2009.
C. Derrick Quarles, Jr. and R. Kenneth Marcus, “Simultaneous Multielement Detection in Particle Beam/Hollow Cathode-Optical Emission Spectroscopy”, Spectrochim. Acta, Part B 64, 1185-1193, 2009.
Joaudimir Castro, Julia C. Spraul and R. Kenneth Marcus, “Metals Analysis of Botanical Products in Various Matrices Using a Single Microwave Digestion and Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) Method”, Anal. Methods 1, 188-194, 2009.
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