Dr. David Gangemi

Director, Institute for Nutraceutical Research, Clemson University, Clemson, SC
Executive Director, National Nutraceutical Center, Clemson, SC

Degrees Held:

Ph.D., Virology/Immunology, University of North Carolina School of Medicine, Chapel Hill, NC

B.S., Microbiology, Clemson University, Clemson, SC

Research Interests:

Viral pathogenesis and immune response to infection – immune modulation in therapy of chronic disease

Antiviral chemotherapy -  interferons and acyclic phosphonate nucleotides in prevention and therapy

Immunotherapy – modulation of TH1 and TH2 responses in therapy and augmentation of vaccine effectiveness

Grant Support:

Evaluation of Echinacea in a Human Rhinovirus Challenge Model,” NIH; Co-PI with R. B. Turner

Novel Cellular and Small Animal Models to Selectively Screen for Nutraceuticals Which Delay Fatigue and Enhance Physical Stamina and Mental Alertness” DOD, Natick Labs; PI

Immunomodulatory properties of Nigella sativa, Immunogan” Shaker Foundation; PI

Nutraceuticals for Sustainable Agriculture in Dominica” USAID; PI

Recent Publications:

Peek, S.F., Bonds, M.D., Gangemi, J.D., Thomas, C.B, and Schultz, R.D. Evaluation of cytotoxicity and antiviral activity of recombinant human interferon alfa-2a and recombinant human interferon alfa-B/D hybrid against bovine viral diarrhea virus, infectious bovine rhinotracheitis virus, and vesicular stomatitis virus in vitro. AJVR, Vol. 65, No. 6, 2004.

Davis, J.M., Carmichael, M.D., Murphy, E.A., Groschwitz, C.M., Brown, A., Zielinski, M., Quig, M., Ghaffar, A., Mayer, E.P., Dunne, C.P., Gangemi, J.D., Depts. of Exercise Science, and Pathology and Microbiology, University of South Carolina, US Army Natick Soldier Center, Dept. of Microbiology and Molecular Medicine, Clemson University.  Animal Model of Performance Enhancement by Nutritional Supplements with Anti-inflammatory Activity. Proceedings 24th Army Science Conference, Orlando, FL, Nov. 30 – Dec. 5, 2004.

Wolkart, K., Gangemi, J.D., Turner, R.B. and Bauer, R.  Enzymatic Degradation of Echinacoside and Cynarin in Echinacaea angustifolia Root Preparations. Pharmaceutical Biology;42:443-448, 2004.

Woelkart, K., Koidl, C., Grisold, A., Gangemi, J.D., Turner, R.B., Marth, E., and Bauer, R. Bioavailability and Pharmacokinetics of Alkamides from the Roots of Echinacea angustifolia in Humans. J Clin Pharmacol; 45:683-689; 2005.

Turner, R.B., Bauer, R., Wolkart, K. Hulsey, T.C. and Gangemi, J.D. An Evaluation of Echinacea angustafolia in Experimental Rhinovirus Infections. New England Journal of Medicine, Volume 353, July 28, No. 4:341-348, 2005.

Download Dr. Gangemi's CV (.pdf, 345 KB)

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