Susan C. Chapman

Associate Professor


Contact Information

132 Long Hall
Phone: 864-656-3384 (lab)
FAX: 864-656-0435
Email: schapm2@clemson.edu


Education

  • Research Associate, University of Utah, 2004-2007
  • Postdoctoral Fellow, University of Utah, 2002-2004
  • Ph.D. Developmental Biology, King's College London, 2002
  • B.S. Open University, 1999
  • B.S. Neuroscience, University College London, 1998

Research Interests


  • Creatine transporter deficiency syndrome affects at least 1 million people, resulting in X-linked intellectual disability (XLID) and autism spectrum disorders (ASDs). Lacking comprehensive genetic testing, this number is likely grossly underestimated, especially in females, who have milder symptoms due to their second X-chromosome and random X-inactivation. SLC6A8 codes for the Creatine transporter (CrT), without which Creatine cannot pass the blood-brain barrier, nor enter neuronal cells, thus hindering ATP metabolic activity in the brain. Patients with SLC6A8 mutations do not respond to treatment with oral Creatine supplements and there are currenlty no available treatments. Using the zebrafish as a model we are testing a new class of Creatine analogs for their ability to cross the blood-brain barrier and enter neuronal cells, thereby rescuing the phenotype.

Selected Publications


Recent Courses

  • BIOL4400/H4400/6400
 Developmental Biology
  • BIOL4610/H4610/6610 Cell Biology
  • BIOL4840/H4840/6840
 Embryology
  • BIOL4910
/4911, H4910 Undergraduate Research in Biological Sciences
  • BIOL4940/4941, H4940 Creative Inquiry - Genetics and Autism


Professional Affiliations

  • AAAS – American Association for the Advancement of Science
  • ASCB – American Society for Cell Biology
  • AAA – American Association of Anatomists
  • Anatomical Society
  • BSDB (British Society for Developmental Biology)
  • SDB (Society for Developmental Biology)