Susan C. Chapman
340 Long Hall
Phone: 864-656-5432 (office), 864-656-3384 (lab)
- Research Associate, University of Utah, 2004-2007
- Postdoctoral Fellow, University of Utah, 2002-2004
- Ph.D. Developmental Biology, King's College London, 2002
- B.S. Open University, 1999
- B.S. Neuroscience, University College London, 1998
- We are interested in mechanisms of tissue specification, morphogenesis and patterning of specific regional identity during vertebrate head development, particularly within the hearing apparatus. In order to understand developmental defects in newborns we use vertebrate animal models to understand normal and abnormal development. The ear has multiple components that need to develop and interact correctly for normal hearing: the outer, middle and inner ear together with the auditory nerve that transmits sounds to the brain. Conductive hearing loss resulting from dysmorphogenesis of this critical component of the hearing apparatus is an important biological and human health problem. Morphogenesis and identification of molecular mechanisms involved in patterning the middle ear from induction to complete organogenesis is an exciting, developing research area.
- The Araucana breed of chicken are rumpless, tufted and lay blue eggs. Genetic analysis reveals that the rumpless and tufted phenotypes result from separate mutations. Analysis of the genetics and molecular mechanism resulting in the rumpless phenotype in these birds will provide insight into the mechanism of caudal spine patterning. Similarly, analysis of the mechanism resulting in middle and outer ear defects of the tufted phenotype will provide insight into syndromes affecting these structures.
- Rooksana E. Noorai*, Nowlan H. Freese*, Lindsay M. Wright**, Susan C. Chapman, Leigh Anne Clark. 2012. Genome-wide Association Mapping and Identification of Candidate Genes for the Rumpless and Ear-tufted Traits of the Araucana Chicken. PLOS One, Vol7, Issue7:1-6.
- Megha Kumar* and Susan C. Chapman. 2012. Cloning and expression analysis of Fgf5, 6 and 7 during early development. Gene Expression Patterns, 12:245-253.
- Megha Kumar*, Poulomi Ray* and Susan C. Chapman. 2012. FGF signaling is required for specifying pre-chondrogenic identity in neural crest derived mesenchyme, but cannot initiate the chondrogenic program. Developmental Dynamics, 241:1091–1103.
2011. Can you hear me now? Understanding vertebrate middle ear development.
Frontiers in Biosciences, 16:1675-1692.
- Jamie L Wood, Ami J Hughes, Kathryn J
Mercer, Susan C. Chapman. 2010. Analysis of chick (Gallus gallus) middle ear columella formation. BMC Developmental
- Steven B. Bleyl, Yukio Saijoh,
Noortje A.M. Bax, Adriana C. Gittenberger-de Groot, Lambertus J. Wisse, Susan C. Chapman, Jennifer Hunter,
Hidetaka Shiratori, Hiroshi Hamada, Shigehito Yamada, Kohei Shiota, Scott E.
Klewer, Mark F. Leppert and Gary C. Schoenwolf. 2010. Dysregulation of the PDGFRA gene causes inflow tract anomalies including
TAPVR: integrating evidence from human genetics and model organisms. Human Molecular
- Christian N. Paxton, Steven B. Bleyl, Susan C. Chapman, Gary C. Schoenwolf.
2009. Identification of differentially expressed genes in early inner ear
Gene Expression Patterns. 10.1016/j.gep.2009.11.002.
- Michelle Warren, Karolina Puskarczyk
and Susan C. Chapman. 2009. Chick Embryo Proliferation Studies Using EdU Labeling. Developmental
Kiyoshi Matsumoto, Qin Cai, Gary C Schoenwolf. 2007. Specification of germ layer identity in the chick gastrula. BMC Developmental
- Susan C Chapman, Kiyoshi Matsumoto, Qin Cai, Gary C Schoenwolf. 2007. Specification of germ layer identity in the chick gastrula. BMC Developmental Biology, 7:91.
- S.C. Chapman, Q,Cai, Steven B. Bleyl and G.C. Schoenwolf. 2006. 2006. Restricted expression of Fgf16 within the developing chick inner ear. Developmental Dynamics. 235:2276-2281.
- S.C. Chapman, A.L. Sawitzke, D. Campbell and G.C. Schoenwolf 2005 A Three-Dimensional Atlas of Pituitary Gland Development in the Zebrafish. J. Comp. Neurol, Jul 11; 487(4):428-40.
- Chapman, S.C., A. Lawson, W.C. MacArthur, R.J. Wiese, R.H. Loechel, M. Burgos-Trinidad, J.K. Wakefield, R. Ramabhadran, T.J. Mauch and G.C. Schoenwolf 2005 Ubiquitous GFP expression in transgenic chickens utilizing a lentiviral vector. Development, 132:935-940.
- Chapman, S.C., Brown, R.P., Lees, L., Schoenwolf, G.C., Lumsden, A. 2004. Expression analysis of chick Wnt and Frizzled genes and selected inhibitors in early chick patterning. Chick Special Issue. Developmental Dynamics. 229:668-676.
- Chapman, S.C., Schubert, F.R.S., Schoenwolf, G.C., Lumsden, A. 2003. Anterior identity is established in chick epiblast by hypoblast and anterior definitive endoderm. Development, 130 (21) 5091-5101.
- Chapman, S.C., Schubert, F.R.S., Schoenwolf, G.C., Lumsden, A. 2002.Analysis of spatial and temporal gene expression patterns in blastula and gastrula stage chick embryos. Developmental Biology. 245 (1) 187-199
- Chapman, S.C., Collignon, J., Schoenwolf, G.C., Lumsden, A. 2001. Improved Method for Chick Whole-Embryo Culture Using a Filter Paper Carrier. Developmental Dynamics, 220:284-289
- BIOSC 440/H440/640
- BIOSC 484/H484/684
- BIOSC/MICRO/GEN 491
Undergraduate Research in Biological Sciences
- BIOSC 494/494L Creative Inquiry
- BIOSC 842
Understanding Cellular Processes
- BIOSC 871 Graduate Student Selected Topics
- BIOSC 891 Masters Dissertation Research
- BIOSC 991 Doctoral Dissertation Research
- Nowlan Freese, B.A.
- Brianna Lam B.S., M.S.
- Christopher McCoy B.A.
- Candler Paige B.S.
- Poulomi Ray B.S., M.S.
- AAAS – American Association for the Advancement of Science
- ASCB – American Society for Cell Biology
- AAA – American Association of Anatomists
- Anatomical Society
- BSDB (British Society for Developmental Biology)
- SDB (Society for Developmental Biology)