Thomas A. Hughes


Contact Information

Phone: 864 656-5433
FAX: 864 656-0435


  • Postdoctoral Fellow, Molecular Genetics, University of Alabama, Birmingham, 1981 - 1983
  • Ph.D. Microbiology, North Carolina State University, 1981
  • M.S. Microbiology, North Carolina State University, 1978
  • B.S. Biology, South Carolina State University, 1975

Research Interests

  • My research interest concerns the bioremediation of an important environmental pollutant, creosote by microoganisms. I am also interested in exploring the control of food-borne pathogens by means other than addition of antibiotics.

Selected Publications

  • Persad, R., and T.A. Hughes. 2006. Molecular Organization of Genes Involved in Polyclic Aromatic Degradation by Sphingomonas paucimobilis EPA 505. Manuscript in preparation.
  • Story, S. P. ,E. L. Kline, T. A. Hughes, and S.S.
    Hayasaka 2004. Degradation of Aromatic Hydrocarbons by Sphingomonas paucimobilis Strain EPA 505. Archives of Environmental Contamination and Toxicology 47: 168-177.
  • Dautle, M., R. L. Ulrich, and T.A. Hughes.
    2004. Antibiotic Sensitivity of 100 Clinical Isolates Purified from Silicone Gastrostomy Tubes Removed from Pediatric Patients. Journal of Applied Research 4: 50-59.
  • Dautle, M., R. L. Ulrich, and T. A. Hughes .
    2003. Species and Sub-species differentiation of 83 Clinical Isolates Purified from Surgically Implanted Silicone Feeding Tubes Using RAPD Amplification. Journal of Clinical Microbiology. 40:414-421.
  • Ulrich, R.L. and T.A. Hughes. 2001. Cloning and Expression Analysis of the 28 KDA Protein from Lactobacillus delbreuckii subsp. lactis ATCC 4797 Synthesized to Influence Lactacin B Production. JAM 91:, (6), 1067-1073.
  • Lim, T., T.A. Hughes, and S.S. Hayasaka, 2001. Rate of Conjugal transfer and Plasmid Deletion of the Tol Plasmid and its Derivatives between Pseudomonas. Arch. Environ. Contam. Toxicol. 40:117-177.
  • Ulrich, R.L. and T.A. Hughes. A Rapid Procedure for Isolating Chromosomal DNA from Lactobacillus species and other Gram-positive Bacteria, 2001. Letters in Applied Microbiology 32 (1) 52 – 56.
  • Bayles, D.O. and T.A. Hughes. 1997. Sequence and Phylogenetic Analysis of the Rhizobium leguminosarum biovar trifolii PyrE gene, and over production, purification and characteriation of ovate phosphorbiosyl transferase. Gene 195,329-336.
  • Presutti, D., T.A. Hughes and F. Stutzenberger.1993 Characterization of a Thermomomspora curvata Endonuclease expressed in Escherichia coli. Journal of Biotechnology. 29:307-320.
  • Presutti, D., T.A. Hughes and F. Stutzenberger. 1991. Cloning of three endoglucanase genes from Thermomonospora curvata in E. coli. Journal of Biotechnology. 17:177-188.
  • Fennington, G. and T.A. Hughes. 1996. The fructokinase from Rhizobium leguminsarum biovar trifolii belongs to group I fructokinase enzymes and is encoded separately from other carbohydrate metabolism enzymes. Microbiology. 142:321-330.

Recent Courses

  • Microbiology 412/ H412/612 - Bacterial Physiology: A Molecular Approach. (1984-present).
  • Microbiology 415 - Microbial Genetics ( 2000).
  • Microbiology 205 - Introduction to Microbiology. (1984-1999).
  • Microbiology 815 - Advanced Microbial Genetics (2001-present).
  • Microbiology 101 - Microbes and Human affairs (1984-2000).
  • CU 101 - Becoming a Master Student (1999-8-2000).
  • Microbiology 491 - Undergraduate Research (1984-1999).
  • Bioinformatics (Food Science Department.Team Taught. Felix Barron, Coordinator)
  • Microbiology 807 - Seminar
  • Microbiology 804 - Selected topics in Microbiology.
  • Microbiology 891 and 991 - Masters and Doctoral Research

Graduate Students

  • Renuka Persad, Ph.D.
  • Jali Jalili, Ph.D.
  • Aaron Brown, M.S.

Professional Affiliations

  • American Society for Microbiology (ASM)
  • International Food Technologist (IFT)