Tamara L. McNealy

Assistant Professor

Phone: 864 656-3058
FAX: 864 656-0435
Email: tmcneal@clemson.edu

Post Doc, Center for Immunology and Microbial Disease, Albany Medical College, 2004-2006
Post Doc, Department of Medical Microbiology and Hygiene, University of Ulm, Ulm Germany, 2002-2004
Ph.D. University of Heidelberg, Heidelberg Germany, 2003
M.S. Middle Tennessee State University, 1999
B.S. University of North Florida, 1992

Virulence mechanisms of intracellular respiratory pathogens, in particular Francisella tularensis and Legionella pneumophila. Investigations into how the natural environment of these pathogens has adapted them for pathogenicity in humans. Host-pathogen interactions; gene regulation/expression in response to environmental signals; expression of bacterial membrane proteins and their involvement in regulation of the host immune response.

Daniel J. Loegering, James R. Drake, Jeffrey A. Banas, Tamara L. McNealy, Debbie G. Mc Arthur, Laura M. Webster, Michelle R. Lennartz. 2006. Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro. Microb Path. In Press.
Broich M, Rydzewski K, McNealy T, Marre R, Flieger A. 2005. The global regulatory proteins LetA and RpoS control phospholipase A, lysophospholipase A, acyltransferase and other hydrolytic activities of Legionella pneumophila. J Bac 188(4): 1218-26.
Shi C, Forsbach-Birk V, Marre R, McNealy T. 2005. The Legionella pneumophila global regulatory protein LetA affects DotA and Mip. Inter J Med Micro 296(1): 15-24.
McNealy T, Forsbach-Birk V, Shi C, Marre R. 2005. The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator csrA. J Bac 187(4): 1527-32.
Forsbach-Birk V, McNealy T, Lynch D, Marre R. 2004. Reduction of the global regulator protein csrA in Legionella pneumophila affects virulence associated regulators and growth in Acanthamobae castellanii. Inter J Med Micro 294: 15-25.