Tamara L. McNealy

Associate Professor

Contact Information

Phone: 864-656-3058
Office: 157B LSF
Lab: 043 LSF
FAX: 864 656-0435
Email: tmcneal@clemson.edu


  • Post Doc, Center for Immunology and Microbial Disease, Albany Medical College, 2004-2006
  • Post Doc, Department of Medical Microbiology and Hygiene, University of Ulm, Ulm Germany, 2002-2004
  • Ph.D. University of Heidelberg, Heidelberg Germany, 2003
  • M.S. Middle Tennessee State University, 1999
  • B.S. University of North Florida, 1992

Research Interests

The McNealy lab is all about adaptability. How do we react to the world around us? In particular how do microbes react to the world around them and how does that affect the way we react to them. The primary niche of most microbes however is a biofilm. In this environment, microbes can exist, persist, survive and adapt to a wide variety of factors.

The biofilms of man-made aquatic systems are our primary interest. Here bacteria, archaea, protozoa and fungi unite and interact. Not only do they interact with each other, but they also respond to a wide array of environmental conditions and contaminants. Understanding these interactions and reactions can lead to advances in how to control and eradicate biofilms as well as potentially identifying unique bacterial genes that can be targeted for development of antimicrobials and therapies. Our research therefore spans the spectrum of microbial ecology to pathogenic microbiology.

Selected Publications

  • Raftery T, Kerscher P, Hart A, Saville S, Qi B, Kitchens C, Mefford OT, McNealy TL. 2013. Discrete nanoparticles induce loss of Legionella pneumophila biofilms from surfaces. Nanotoxicology. In press
  • Raftery T, Lindler H, McNealy TL. 2013. Altered host-pathogen interactions due to nanoparticle interaction with a bacterial biofilm. Microbial Ecol. 65(2):496-503
  • Mahajan UV, Gravgaard J, Turnbull M, Jacobs D and TL McNealy. 2011. Larval exposure to Francisella tularensisLVS affects fitness of the mosquito Culex quinquefasciatus. FEMS Microb Ecol. 78 (3): 520-30.
  • Stojak AR, Raftery T, Klaine SJ, and McNealy TL. 2011. Morphological responses of Legionella pneumophilabiofilms to nanoparticle exposure. Nanotoxicology.5(4): 730–742.
  • Gravgaard J, Turnbull M, and McNealy T. 2010. A novel technique for feeding and confirming uptake of bacteria in larvae of the southern house mosquito Culex quinquefasciatus. Florida Entomologist. 93 (4): 577-583.
  • Forsbach-Birk V, McNealy T, Lynch D, Marre R. 2004. Reduction of the global regulator protein csrA in Legionella pneumophila affects virulence associated regulators and growth in Acanthamobae castellanii. Inter J Med Micro 294: 15-25.
  • McNealy T, Forsbach-Birk V, Shi C, Marre R. 2005. The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator csrA. J Bac 187(4): 1527-32
  • Shi C, Forsbach-Birk V, Marre R, McNealy T. 2005. The Legionella pneumophila global regulatory protein LetA affects DotA and Mip. Inter J Med Micro 296(1): 15-24
  • Broich M, Rydzewski K, McNealy T, Marre R, Flieger A. 2005. The global regulatory proteins LetA and RpoS control phospholipase A, lysophospholipase A, acyltransferase and other hydrolytic activities of Legionella pneumophila. J Bac 188(4): 1218-26.
  • Daniel J. Loegering, James R. Drake, Jeffrey A. Banas, Tamara L. McNealy, Debbie G. Mc Arthur, Laura M. Webster, Michelle R. Lennartz. 2006. Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro. Microb Path.

Recent Courses

  • Micro 4110/4110H/6110: Bacterial Pathogenesis (every Spring Semester)
  • Micro 8070: Microbiology Journal Club (select semesters)
  • Micro 8060: Paradigms of Infectious Disease (Fall, Odd Years)
  • MICR 4940/4940H: Creative Inquiry: Biofilms Interactions
  • MICR3940/4940/H: Creative Inquiry: CU and the CDC

Graduate Students

    • Brennen Jenkins, MS Micro
    • Andrew Harmon, MS Micro
    • Katie Jwanowski, MS Micro 

    Professional Affiliations

      • American Society of Microbiology: 1999-present
      • Society of Environmental Toxicology and Chemistry (2009-present)