Xianzhone Yu

Associate Professor



Contact Information

Phone: 864 455-5339
FAX: 864 656-0435
Email: xyu@clemson.edu

Education

  • Ph.D. Molecular & Cellular Biology, Ohio University, 1998
  • MS. Animal Science, ChangChun University of Agriculture and Animal Science, 1988

Research Interests

  • Experimental tumor therapy, especially in the area of tumor and tumor microenvironment activated pro-drug therapy. We have been working on modified toxins as well as conditional replicating virus as ways to target tumors.
  • Establishing disease models through transgenic technique and gene knockout.
  • Tumor related kinase inhibitor screening from traditional  medicinal herbs.

Selected Publications

  • Holle L, H. L., Song W, Holle E, Wagner T, Yu X. "Bcl-2 targeting siRNA expressed by a T7 vector system inhibits human tumor cell growth in vitro." Int J Oncol. 24(3): 615-621 (2004).
  • Peiyong Zhai, Mitsutaka Yamamoto, Jonathan Galeotti, Jing Liu, Malthi Masurekar, Jill Thaisz, Keiichi Irie, Eric Holle, Xianzhong Yu, et al. “Cardiac-specific Overexpression of AT1 Receptor Mutant Lacking G?q/G?i Coupling Causes Hypertrophy and Bradycardia in Transgenic Mice”. The Journal of Clinical Investigation. Accepted for publication 115(11): 2971-2974 (2005).
  • Holle L, S. W., Hicks L, Holle E, Holmes L, Wei Y, Li J, Wagner T, Yu X. "In vitro targeted killing of human endothelial cells by co-incubation of human serum and NGR peptide conjugated human albumin protein bearing alpha (1-3) galactose epitopes." Oncol Rep. 11(3): 613-616 (2004).
  • Ji J, L. J., Holmes LM, Burgin KE, Yu X, Wagner TE, Wei Y. "Synergistic anti-tumor effect of glycosylphosphatidylinositol-anchored IL-2 and IL-12." J Gene Med. 6: 777-785 (2004).
  • Li J, J. J., Holmes LM, Burgin KE, Barton LB, Yu X, Wagner TE, Wei Y. "Fusion protein from RGD peptide and Fc fragment of mouse immunoglobulin G inhibits angiogenesis in tumor." Cancer Gene Ther. 11: 363-370 (2004).
  • Barnett FH, S.-S. M., Wood M, Yu X, Wagner TE, Friedlander M. "Intra-arterial delivery of endostatin gene to brain tumors prolongs survival and alters tumor vessel ultrastructure." Gene Ther. 11: 1283-1289 (2004).
  • Li JH, B.-V. H., Holmes LM, Burgin KE, Jakubchak s, Yu xz, Wagner TE, Wei YZ "Inhibition or promotion of tumor growth by gradulocyte-macrophage colony stimulating factor derived from engineered tumor cells is dose-dependent." Anticancer research 24: 2717-2722 (2004).
  • Yamamoto M, Y. G., Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF, Sadoshima J. "Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy." J Clin Invest. 112(9): 1395-1406 (2003).
  • Li J, F. K., Patterson AL, Holmes LM, Burgin KE, Ji J, Yu X, Wagner TE, Wei Y. "Targeting foreign major histocompatibility complex molecules to tumors by tumor cell specific single chain antibody (scFv)." Int J Oncol. 23(5): 1329-1332 (2003).
  • Holle L, S. W., Holle E, Wei Y, Wagner T, Yu X. "A matrix metalloproteinase 2 cleavable melittin/avidin conjugate specifically targets tumor cells in vitro and in vivo." Int J Oncol. 22(1): 93-98 (2003).

Graduate Students

  • Amma Bosompem, M.S.
  • Mengmeng Zhong, Ph.D.

Professional Affiliations

  • American Association for Cancer Research