Xianzhong (George) Yu

Associate Professor

Contact Information

Phone: 864 455-5339
FAX: 864 656-0435
Email: xyu@clemson.edu


Education

  • Ph.D. Molecular & Cellular Biology, Ohio University, 1998
  • MS. Animal Science, ChangChun University of Agriculture and Animal Science, 1988

Research Interests

  • Experimental tumor therapy, especially in the area of tumor and tumor microenvironment activated pro-drug therapy. We have been working on modified toxins as well as conditional replicating virus as ways to target tumors.
  • Establishing disease models through transgenic technique and gene knockout.
  • Tumor related kinase inhibitor screening from traditional  medicinal herbs.

Selected Publications

  • Zhou LN, Zhao ZH, et al. “An IL-12/Shh-C domain fusion protein-based IL-12 autocrine loop for sustained natural killer cell activation.”  Int J Oncol. 41(2):661-9 (2012)
  • Jinhua Li, et al. “Antitumor activity of fermented noni exudates and its fractions.” Molecular and Clinical Oncology. 1(1): 161-164 (2012)
  • Holle L, H. L., Song W, Holle E, Wagner T, Yu X. "Bcl-2 targeting siRNA expressed by a T7 vector system inhibits human tumor cell growth in vitro." Int J Oncol. 24(3): 615-621 (2004).
  • Basma Damiri, Eric Holle, Xianzhong Yu, and William S. Baldwin. “Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.” Toxicol. Sci. 125(2):368-81 (2012)
  • Zhao et al. “Anti-tumor and anti-angiogenesis activities of Scutellaria barbata extracts in vitro is partially mediated by inhibition of Akt/Protein Kinase B.” Molecular Medicine Reports, 5: 788-792, (2012)
  • Holle L, et al. “In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two  -linked glutamate residues at the COOH terminus” Molecular Medicine Reports, 2: 399-403, (2009)
  • Holle L, et al. (2009) “In Vitro and In Vivo Targeted Tumor Lysis by a MMP2 cleavable Melittin-LAP Fusion Protein” International Journal of Oncology, 35:829-835
  • Branham-O'Connor M, Li J, Kotturi HS, Yu X, Wagner TE, Wei Y (2010) “Fusion induced reversal of dendritic cell maturation: an altered expression of inflammatory chemokine and chemokine receptors in dendritomas”. Oncol Rep. 23(2):545-50
  • Collins NH, Lessey EC, Dusell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing A, Lessey BA. “Characterization of Anti-Estrogenic Activity of the Chinese Herb, Prunella vulgaris, Using In Vitro and In Vivo (Mouse Xenograft) Models.” Biol Reprod. 2008 Oct 15. [Epub ahead of print]
  • Kotturi, H. S., J. Li, et al. (2008). "Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activation." Gene Ther. 15 : 1302-1310
  • Holle L, S. W., Holle E, Wei Y, Wagner T, Yu X. "A matrix metalloproteinase 2 cleavable melittin/avidin conjugate specifically targets tumor cells in vitro and in vivo." Int J Oncol. 22(1): 93-98 (2003).
  • Kotturi HS, Li J, Branham-O'Connor M, Yu X, Wagner TE, Wei Y. (2010). “In vitro and in vivo delivery of novel anticancer fusion protein MULT1E/FasTI via adenoviral vectors.” Cancer Gene Ther. 17(3): 164-170
  • Alexander Y. Wagner, E. H., Lori Holle, Xianzhong Yu, Gunter Schwamberger (2008). "Immunological tolerance and tumor rejection in embryo-aggregated chimeric mice - Lessons for tumor immunity." BMC Cancer 8: 370.
  • Yutaka Matsui, Noritsugu Nakano, Dan Shao, et al. (2008). “Lats is a negative regulator of myocyte size in the heart.” Circ Res. 103: 1309-1318
  • Zhai P, Gao S, Holle E, Yu X, Yatani A, Wagner T, Sadoshima J. “Glycogen synthase kinases-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal regulated kinases.” J. Biol Chem. Sep 12; [Epub ahead of print] (2007)
  • Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J. “Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart.” Circ Res. 2007 Apr 19; [Epub ahead of print]
  • Zhai P, Galeotti J, Liu J, Holle E, Yu X, Wagner T, Sadoshima J, “An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy.” Cir Res. 2006, 99(5): 528-536
  • Lessey, E. C.; Mo, B.  L.; Yu, X.; Lessey, B.  A. “The Chinese Herb, Prunella Vulgaris, Exhibits Anti-Estrogenic Activity and Inhibits Proliferation of the Endometrial Cancer Cell Line, ECC-1”, J. Soc. Gynecol. Investig. 2005, 12(2) (supplement), 90A.
  • Peiyong Zhai, Mitsutaka Yamamoto, Jonathan Galeotti, Jing Liu, Malthi Masurekar, Jill Thaisz, Keiichi Irie, Eric Holle, Xianzhong Yu, et al. “Cardiac-specific Overexpression of AT1 Receptor Mutant Lacking G alpha q/Galpha i Coupling Causes Hypertrophy and Bradycardia in Transgenic Mice”. The Journal of Clinical Investigation. 115(11):3045-3056 (2005).
  • Holle L, S. W., Hicks L, Holle E, Holmes L, Wei Y, Li J, Wagner T, Yu X. "In vitro targeted killing of human endothelial cells by co-incubation of human serum and NGR peptide conjugated human albumin protein bearing alpha (1-3) galactose epitopes." Oncol Rep. 11(3): 613-616 (2004).
  • Ji J, L. J., Holmes LM, Burgin KE, Yu X, Wagner TE, Wei Y. "Synergistic anti-tumor effect of glycosylphosphatidylinositol-anchored IL-2 and IL-12." J Gene Med. 6: 777-785 (2004).
  • Li J, J. J., Holmes LM, Burgin KE, Barton LB, Yu X, Wagner TE, Wei Y. "Fusion protein from RGD peptide and Fc fragment of mouse immunoglobulin G inhibits angiogenesis in tumor." Cancer Gene Ther. 11: 363-370 (2004).
  • Barnett FH, S.-S. M., Wood M, Yu X, Wagner TE, Friedlander M. "Intra-arterial delivery of endostatin gene to brain tumors prolongs survival and alters tumor vessel ultrastructure." Gene Ther. 11: 1283-1289 (2004).
  • Li JH, B.-V. H., Holmes LM, Burgin KE, Jakubchak s, Yu xz, Wagner TE, Wei YZ "Inhibition or promotion of tumor growth by granulocyte-macrophage colony stimulating factor derived from engineered tumor cells is dose-dependent." Anticancer research 24: 2717-2722 (2004).
  • Yamamoto M, Y. G., Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF, Sadoshima J. "Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy." J Clin Invest. 112(9): 1395-1406 (2003).
  • Li J, F. K., Patterson AL, Holmes LM, Burgin KE, Ji J, Yu X, Wagner TE, Wei Y. "Targeting foreign major histocompatibility complex molecules to tumors by tumor cell specific single chain antibody (scFv)." Int J Oncol. 23(5): 1329-1332 (2003).
  • Holle L, S. W., Holle E, Wei Y, Wagner T, Yu X. "A matrix metalloproteinase 2 cleavable melittin/avidin conjugate specifically targets tumor cells in vitro and in vivo." Int J Oncol. 22(1): 93-98 (2003).
  • Roy I, H. L., Song W, Holle E, Wagner T, Yu X. "Efficient translocation and apoptosis induction by adenovirus encoded VP22-p53 fusion protein in human tumor cells in vitro." Anticancer Res. 23(6A): 3185-3189 (2002).
  • Ji J, L. J., Holmes LM, Burgin KE, Yu X, Wagner TE, Wei Y. "Glycoinositol phospholipid-anchored interleukin 2 but not secreted interleukin 2 inhibits melanoma tumor growth in mice." Mol Cancer Ther. 1(12): 1019-1024 (2002)
  • Depre C, H. M., Gaussin V, Zajac A, Wang L, Hittinger L, Ghaleh B, Yu X, Kudej RK, Wagner T, Sadoshima J, Vatner SF. "H11 kinase is a novel mediator of myocardial hypertrophy in vivo." Circ Res. 91(11): 1007-1014 (2002).
  • Warren P, S. W., Holle E, Holmes L, Wei Y, Li J, Wagner T, Yu X. "Combined HSV-TK/GCV and secondary lymphoid tissue chemokine gene therapy inhibits tumor growth   and elicits potent antitumor CTL response in tumor-bearing mice." Anticancer Res. 22(2A): 599-604 (2002).
  • Warren P, L. L., Song W, Holle E, Wei Y, Wagner T, Yu X. "In vitro targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two gamma-linked glutamate residues at the COOHterminus." Cancer Res. 61(18): 6783-6787 (2001).
  • Wei Y, L. J., Chen WY, Yu X, Sticca RP, Wagner TE. "Enhanced transgene expression and effective in vivo antitumor immune responses initiated by dendritic progenitors transfected with a nonviral T7 vector expressing a model tumor antigen." J Immunother. 23(1): 75-82 (2000).
  • Ji H, Yu. X., Wagner TE. "A long-term culture system for the expansion of hematopoietic stem cells from embryonic yolk sac with the capacity to seed erythroid and lymphoid development in vitro and to reconstitute the lymphoid compartment in severe combined immunodeficient mice." Artif Organs. 20(10): 1093-1109 (1996).
  • Jinhua Li, S.L.S., Hilary Bouton-Verville, Kelly E. Burgin, Xianzhong Yu, 
  • Desmond K.W. Wong, Thomas E. Wagner, Yanzhang Wei, Fermented NoniExudate (fNE): A mediator between immune system and anti-tumor activity.    Oncology Reports, 2008. 20(6): p. 1505.
  • Lining Zhu, Xianzhong Yu. Sustained self-activation of NK cells in vitro and in vivo by expression of IL-12-shh-C fusion proteins. Journal of leukocyte Biology, 2011. Supplement 2011: S43

Graduate Students

  • Amma Bosompem, M.S. graduated
  • Mengmeng Zhong, M.S. graduated
  • Lining Zhu, Ph.D. graduated

Professional Affiliations

  • American Association for Cancer Research