PPhD Plant Pathology & Microbiology
Texas A&M University 2000
PhD Biological Sciences
Dartmouth College 1998
Gordon College 1988
GEN 4200 Molecular Genetics and Gene Regulation
GEN 4200 Honors Molecular Genetics and Gene Regulation
GEN 6200 Graduate Molecular Genetics and Gene Regulation
GEN/BCHM 8050 Issues in Research
I am a member of the American Society of Plant Biologists, the International Society for Molecular Plant-Microbe Interactions, the Society for Experimental Biology, the Genetics Society of America and the Association for Women in Science.
Legume plants set up a symbiosis with nitrogen fixing bacteria, supplying carbon from photosynthesis to the bacteria while the bacteria fix nitrogen from the air for the plant inside special plant root structures called nodules. My lab focuses on molecular genetics in the legume model system Medicago truncatula. Our goal is to identify the plant genes, hormones and environmental signals involved in nodule number regulation and construct a signal transduction pathway for this process. These signals are part of a long distance communication pathway between the roots and shoots and many of the genes involved in plant control of nodulation are genes involved in general plant growth and development, making our findings applicable to all plants. The components of our model include multiple genes identified by forward genetics and the plant hormones auxin, cytokinin and ethylene. Because the plant can sense its nitrogen needs and balance those needs with its carbon resource, perception and processing of these signals also influences nodule number. Thus discovering how the plant regulates nodule number will also help determine how the plant “thinks” and “decides” when confronted with the challenge of being a sessile organism that must find and respond to nutrient sources.
My research is my passion, but I also have a professional interest in research ethics, specifically the encouragement and transmission of ethical research practices (often called \\\"best practices\\\") to graduate students, and the definition of these practices. To that end, I interact frequently with the Rutland Institute for Ethics and the Office of Research Integrity and am a member of the Association for Practical and Professional Ethics and Sigma Xi. I also am an advocate for Inclusive Excellence, especially women in science.
(apologies on the format-our new system does not allow even italics)
Kassaw, T., Nowak, S., Schnabel, E., and Frugoli, J. (2017) ROOT DETERMINED NODULATION1 is required for M. truncatula CLE12, but not CLE13 peptide signaling through the SUNN receptor kinase, Plant Physiology. 174: 2445-2456.
Crook, A., Schnabel, E., and Frugoli, J. (2016) The systemic nodule number regulation kinase SUNN in Medicago truncatula interacts with MtCLV2 and MtCRN, The Plant Journal, 88: 108-119. doi: 10.1111/tpj.13234.
Kassaw, T., Schnabel, E., Bridges, W. and Frugoli, J. (2015) Multiple autoregulation of nodulation (AON) signals identified through split root analysis of M. truncatula sunn and rdn1 mutants, Plants 4:209-224.
Kassaw, T. and Frugoli, J. (2013) Journey to Nodule Formation: From Molecular Dialogue to Nitrogen Fixation, Symbiotic Endophytes, R. Aroca, ed, Springer Soil Biology series Vol 37 pp 3-24.
Kassaw, T. and Frugoli, J, (2012) Simple and efficient methods to generate split roots and grafted plants useful for long-distance signaling studies in Medicago truncatula and other small plants, Plant Methods, 8:38
Frugoli, J., (2012) Be Careful What You Wish For: Research Ethics Education in the University Setting, A Response to NIH and NSF Regulations, Teaching Ethics, 12:2, 103-105.
Schnabel, E., Karve, A., Kassaw, T., Mukherjee, A., Zhou, X., Hall, T., and Frugoli, J. (2012) The M. truncatula SUNN gene is expressed in vascular tissue, similarly to RDN1, consistent with the role of these nodulation regulation genes in long distance signaling, Plant Signaling and Behavior, 7:1-3.
Schnabel, E., Kassaw, T., Smith, L. Marsh, J., Oldroyd, G., Long, S. and Frugoli, J. (2011) ROOT DETERMINED NODULATION 1 regulates nodule number in M. truncatula and defines a highly conserved, uncharacterized plant gene family, Plant Physiology, 157: 328-340.
Schnabel, E., Smith, C., Long, S. and Frugoli, J. (2010) Transcript profiling in M. truncatula lss and sunn-1 mutants reveals different expression profiles despite disrupted SUNN gene function in both mutants, Plant Signaling and Behavior, 5:1657-1659.
Schnabel, E., Mukherjee, A., Smith, L. Kassaw, T. Long, S. and Frugoli, J. (2010) The lss supernodulation mutant of Medicago truncatula reduces expression of the SUNN gene, Plant Physiology 154: 1390-1402.
Frugoli, J., Etgen, A. M. and Kuhar, M. (2010) Developing and Communicating Responsible Data Management Policies to Trainees and Colleagues, Science & Engineering Ethics, 16:753-762.
Ané, J.M., Zhu, H., and Frugoli, J. (2008) Recent advances in Medicago truncatula genomics, International Journal of Plant Genomics, Vol 2008, Article ID 256597, doi:10.1155/2008/256597.
Frugoli, J. (2008) Medicago truncatula as a model plant in Plant Molecular Biology, in Handbook of New Technologies for Genetic Improvement of Legumes, P.B. Kirti, ed., The Haworth Press, New York pp 339-352.