Lisa J. Bain
- Post-doctoral Associate, Fox Chase Cancer Center, Medical Oncology, 1998
- Ph.D., North Carolina State University, Toxicology, 1997.
- B.S., University of Georgia, Environmental Health Sciences, 1992.
- Understanding the mechanisms by which arsenic causes developmental toxicity
- Determining how ATP-dependent transport proteins alter the metabolism, disposition, and elimination of drugs and toxicants
in my laboratory focuses on the mechanisms by which cells respond to toxicants,
such as arsenic, chromium, and pharmaceuticals.
first project investigates how arsenic delays cellular and organismal
differentiation and development. Arsenic is a contaminant in drinking
water in many parts of the world, and has been found at appreciable levels in
rice and juices. Arsenic readily crosses the placental barrier and exposure
is correlated with adverse developmental outcomes such as stillbirths,
spontaneous abortions, neonatal mortality, low birth weight, delays in the use
of musculature, and altered neuronal function. We are examining arsenic’s
effects on development and cellular differentiation in both cell lines and fish
embryos using microarrays, qPCR, and immunohistochemical techniques.
second project examines ATP-dependent transport proteins, specifically Mrp1 and
Mrp2, which are involved in the elimination of compounds from the liver,
kidney, and intestine. This active elimination lowers both the concentration
and the toxicity of the compound to the organism. We are examining how these
transporters are regulated, what their normal physiological roles are,
elucidating toxicants that may interfere with these protein pumps, and whether
co-regulation exists between phase I and phase II enzyme systems and
- Hong G-M
and Bain LJ (2012) Arsenic exposure
inhibits myogenesis and neurogenesis in P19 stem cells through repression of
the b-catenin signaling pathway, Toxicological
JC, Ancrum TM, and Bain LJ (2012)
Loss of Mrp1 alters detoxification enzyme expression in a tissue- and
hormonal-status specific manner, Journal
of Applied Toxicology, Epub, PMID: 22522787.
- Green BR
and Bain LJ (2012) Mrp2 is involved
in the efflux and disposition of fosinopril, Journal of Applied Toxicology, Epub, PMID: 22095822.
- Hong G-M and Bain LJ (2012) Sodium arsenite represses the
expression of myogenin in C2C12 mouse myoblast cells through histone
modifications and altered expression of Ezh2, Glp, and Igf-1, Toxicology and Applied Pharmacology,
KM, Chapman RW, Neely MG, D’Amico AR, and Bain
LJ (2012) Arsenic exposure in killifish during embryogenesis
alters muscle development and structure, Toxicological
- Steffens AA, Hong G-M, and Bain LJ (2011) Sodium arsenite delays
the differentiation of C2C12 mouse myoblast cells and alters methylation
patterns on the transcription factor myogenin, Toxicology and Applied Pharmacology, 250:154-161.
- Gonzalez HO, Hu J,
Gaworecki KM, Roling JA, Baldwin WS, Gardea-Torresdey JL, and Bain LJ
(2010) Dose-responsive gene expression changes in juvenile and adult mummichogs
(Fundulus heteroclitus) after arsenic exposure, Marine Environmental
- Sivils JC, Gonzalez
I, and Bain LJ (2010) Mice lacking MRP1 have reduced testicular steroid
hormone levels and alterations in steroid biosynthetic enzymes, General and
Comparative Endocrinology, 167:51-59.
- Burnett KG, Bain
LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Comez-Chiarri
M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer
JN, Nacci DE, Oleksiak MF, Rees BB, Singer TP, Stegeman JJ, Towle DW, Van Veld
PA, Vogelbein WK, Whitehead A, Winn RN, and Crawford DL (2007) Fundulus
as the premier teleost model in environmental biology: opportunities for
new insights using genomics, Comparative Biochemistry and Physiology
part D 2:257-286.
- ENTOX 430/630 Toxicology
- BIOSCI 461/661 Cell Biology
Previous Courses Taught
- Environmental Stressors in the Ecosystem
- General Biology
- Society of Toxicology
- Society of Environmental Toxicology and Chemistry