William R. Marcotte, Jr.

Associate Professor



Contact Information

Phone: 864 656-0119
FAX: 864-656-6879
Email: marcotw@clemson.edu


Education

  • Ph.D. Microbiology, University of Virginia School of Medicine
  • B.S. Biochemistry, Virginia Polytechnic Institute & State University

Research Interests

  • Dr. Marcotte's laboratory is interested in a group of genes (late embryogenesis abundant or lea genes) and their corresponding proteins (LEA proteins) that are expressed to high levels in plant embryos. Current projects include molecular analyses of: 1) transcriptional regulation of gene expression by the phytohormone abscisic acid; 2) the regulation of messenger RNA stability and RNA binding proteins involved in this phenomenon (post-transcriptional regulation); 3) the physiological role of Group 1 LEA proteins in desiccation tolerance. These studies use numerous molecular approaches including recombinant DNA techniques, transient expression systems and stable plant transformation.

Selected Publications

  • Manfre, AJ, Lanni, LM and Marcotte Jr, WR (2006). The Arabidopsis thaliana Group 1 LEA Protein ATEM6 is Required for Normal Seed Development. Plant Physiol 140:xx-xx.
  • Teule', F, Jung, S, Wood, J, Marcotte, WR Jr, Ellison, MS and Abbott, AG (2002). Biomimetic manufacturing of fibers. In Design and Nature (Brebbia, CA, Sucharov, LJ and Pascolo, P, eds.), pp. 379-390.
  • Paradkar, MR and Marcotte, WR Jr (2001). A Possible Stem-loop Structure in the Em 5' UTR Affects Reporter Gene Expression in vivo and in vitro. J Plant Physiol 158:929-934.
  • Nelsen, NS and Marcotte, WR Jr (2000). A Wheat Group 1 LEA Intron Enhances b-glucuronidase Gene Expression in Cereal Cells. J Plant Physiol 157:677-684.
  • Swire-Clark, GA and Marcotte, WR Jr (1999). The wheat LEA protein Em functions as an osmoprotective molecule in Saccharomyces cerevisiae. Plant Mol Biol 39:117-128.
  • Nelsen, NS and Marcotte, WR Jr (1999). Introduction of a wheat Group 1 LEA intron into the b-glucuronidase coding region results in enhanced expression in cereal cells. Manuscript in preparation.
  • Marcotte, WR Jr, Nelsen, NS and Paradkar, MR (1999). Two Wheat 5' Untranslated Regions Affect Expression Differently In Vivo and In Vitro. Manuscript in preparation.

Recent Courses

  • BIOSC 815 - Developmental Genetics
  • BIOSC/GEN 465/665 - Plant Molecular Biology
  • BIO/GEN 418/618 - Biotechnology I - Nucleic Acid Techniques

Graduate Students

  • Naoma Nelsen
  • Ginger Swire-Clark
  • Manjiri Paradkar

Professional Affiliations

  • American Society of Plant Physiologists