Edward B. Pivorun
Phone: 864 656-3592
FAX: 864 656-0435
- Ph.D. Zoology, University of Minnesota
- B.S. Biology, Tufts University
- The physiological states of
hibernation and daily torpor are characterized by profound
readjustments in the metabolic status of the individual. The reduced
maintained during hibernation and torpor represents
a controlled physiological and biochemical status. Dr. Pivorun's
primary areas of research deal with the neuromodulation of torpor. Computerized radiotelemetry, in conjunction with HPLC, RIA, water-perfused thermodes and intracerebral cannulation
is used to determine the influence of the brain monoamines, neuropeptides, and melatonin on
torpor. Investigations in this laboratory have examined six topics: 1)
the effects of intracerebral delivery of norepinephrine, bombesin and
serotonin on thermoregulation in the ground squirrel and the deermouse;
2) the functional integrity of the pre-optic/anterior hypothalamic
thermoregulatory centers during daily torpor and hibernation; 3) the
role of the endorphins in neuromodulation of daily torpor and feeding;
4) the role of the pineal gland and melatonin in hibernation; 5) the
metabolic and body temperature rhythms occurring during torpor and 6)
changes in levels of biogenic amenes in discrete areas of the brain
during the various stages of torpor and hibernation.
Current interests center on (1) the role of neuropeptides and
neuroendocines in modulating the physiological state of daily torpor
and (2) the population dynamics of small mammals in the Great Smoky
Mountains National Park.
- Pivorun, E.
and A. Nordone. 1996. Brain Synaptosomes Display a Diadenosine
Tetraphosphate (Ap4A) Mediated Ca2+ Influx Distinct from ATP Mediated
Neurosci. Res. 44:478-489.
- Nordone, A.J. and Pivorun, E.
1995. Cytosolic calcium responses to extracellular adeosine 5',5'''-Pl,
P4-tetraphosphate in PC12 cells. Pharm. Biochem. Behav. 52
- Hulihan, B., Pivorun, E. and D. Goldman. 1993. Diurnal Rhythms of 5-HT1A and 5-HT2 Receptors Binding in Euthermic and Torpor Prone Deermice, Peromyscus
maniculatus. Pharm. Biochem. Behav. 45:785-789.
- Hulihan, B., Park, .Y., Pivorun, E. and D. Goldman. 1993. Regional Analysis of 5-HT1A receptors in two species of Peromyscus. Pharm. Biochem. Behav. 45:143-145.
- Edwards, M. and E. Pivorun.
1991. The effects of photoperiod and different dosages of melatonin on
metamorphic rate and weight gain in Xenopus laevis tadpoles. Gen. Comp.
- Lin, L. and E. Pivorun.
1989. Hypothalamic monoamines and their metabolites in the deermouse.
Peromyscus maniculatus during daily torpor. J. Neural Transmission
- Lin, L. and E. Pivorun.
1989. Analysis of monoamines and their metabolites in the hypothalamus,
suprachiasmatic nucleus and the pineal gland of euthermic and torpid
deermice, Peromyscus maniculatus. In: Living in the Cold II. Ed. A.
Malan and B. Canguilhem. Colloque INSERM/John Libbey Eurotext Ltd. pp.
Previous Courses Taught
- BIOSC 464, 664 Mammalogy;
- BIOSC 475, H475, 675 Comparative Physiology;
- BIOSC 871 Special Topics in Physiology
Professional Society Affiliations
- American Society of Mammalogists
- American Society of Cell Biology