Dr. Michael Sehorn

Assistant Professor
Ph.D. Biochemistry and Molecular Biology
2001, Louisiana State University

Research Interests
Mechanisms of Meiotic Recombination
Protein Biochemistry
Structure-Function Relations
Protein-Nucleic Acid Interactions

Office: 314 Biosystems Research Complex
Phone: (864) 656-2572
Email: msehorn@clemson.edu

Research Activities

Sexual reproduction is dependent upon a specialized type of cell division called meiosis. Early in meiosis, homologous chromosomes pair with each other and are physically linked together by recombination. Linkage of the homologous chromosomes is critical for proper segregation of the chromosomes to opposites poles in the cell. Our research is focused on the mechanism of recombination during meiosis.

Recent Publications

Chi, P., San Filippo, J., Sehorn, M.G., Petukhova, G. V., Sung P. (2007) Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. Genes Dev. 21(14):1747-57.

San Filippo, J., Chi, P., Sehorn, M.G., Etchin, J., Krejci, L., Sung, P. (2006) Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. J. Biol. Chem. 281(17):11649.

Chi, P., Van Komen, S., Sehorn, M.G., Sigurdsson, S., Sung, P. (2006) Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function. DNA Repair. 5(3):381-91.

Van Komen, S., Macris, M., Sehorn, M.G., Sung, P. (2006) Purification and assays of Saccharomyces cerevisiae homologous recombination proteins. Methods Enzymology. 408:445-63.

Sehorn, M.G., Sung, P. (2004) Meiotic recombination: an affair of two recombinases. Cell Cycle. 3(11):1375-7.

Additional Publication Resources