About
Jason J. Marx, MD, MBA is a nationally recognized physician leader and board-certified specialist in pulmonary disease, critical care medicine, and sleep medicine, with more than three decades of clinical, academic, and executive experience. He currently serves as President of Prisma Health Medical Group and Clinical Associate Professor of Medicine at the University of South Carolina School of Medicine in Greenville, South Carolina. He leads large-scale physician integration, clinical operations, and value-based care initiatives. Dr. Marx received his undergraduate degree from Princeton University, earned his MD with Alpha Omega Alpha honors from Georgetown University School of Medicine, completed residency and chief residency at Standford University Medical Center, fellowship training at Johns Hopkins University, and later obtained an MBA from Loyola University Maryland. Over his career, he has held numerous senior leadership roles across major academic health systems including the University of Maryland Medical System and University of Pittsburgh Medical Center. He has served as department chair and contributed extensively to quality, safety, and population health initiatives. He has authored peer-reviews publications in leading medical journals, held academic appointments at Johns Hopkins University and the University of Maryland. His primary research has focused on sleep disorders and the pathophysiology and clinical manifestations of obstructive sleep apnea. More recently he has focused on emergency responses to the COVID-19 pandemic. He has a longstanding commitment to clinical excellence, physician leadership development, and healthcare operational and clinical transformation.
How their research is transforming health care
Drawing on fellowship training in Pulmonary, Critical Care, and Sleep Medicine at Johns Hopkins, my research has focused on the pathophysiology and clinical consequences of sleep-disordered breathing, as well as system-based responses to critical illness and public health crises.
My early investigative work examined the neuromechanical control of the upper airway during sleep and the mechanisms underlying obstructive sleep apnea (OSA). Through physiologic studies published in Sleep and the Journal of Applied Physiology, I explored chemoreflex control, upper airway collapsibility, and the differential contributions of obstructive sleep apnea during REM and NREM sleep to daytime sleepiness. This work helped clarify how obesity, ventilatory control, and upper airway muscle responsiveness interact to influence OSA severity and clinical symptoms. I also contributed to investigations of novel therapeutic strategies, including high flow transtracheal insufflation and upper airway hypoglossal nerve stimulation.
Subsequently, my scholarship expanded to health systems science and crisis standards of care. During the COVID-19 pandemic, I collaborated on multi-institutional efforts to develop operational frameworks or scarce resource allocation and to analyze changes in respiratory disease utilization patterns. These publications addressed ethical, clinical, and systems-level dimensions of critical care delivery in times of strain.
My current role as President of Prisma Health Medical Group will allow me to connect CUSHR faculty with the almost 4,000 physicians and advanced practice providers across Prisma Health to further clinical, translational, and systems-based research to transform healthcare across the state, the region, and the country.
Health research keywords
Sleep Disorders, Obstructive Sleep Apnea, Crisis Standards of Care, Healthcare Delivery and Operations, Value-Based Care
