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School of Health Research

Nicholas Perkins, M.D.


Clinical Associate Professor
Clemson University School of Health Research
Prisma Health
Associate Chief Medical Informatics Officer


Dr. Nicholas Perkins is currently the Associate Chief Medical Informatics Officer for Prisma Health. In this role Dr. Perkins provides leadership in multiple informatics domains, including optimization of the organization’s electronic health records system, serving as the system’s lead Epic Physician Builder, and developing a comprehensive clinical and operational analytics strategy. He also serve as the program director for an ACGME Clinical Informatics Fellowship with an anticipated first matriculation in 2025. When not working in clinical informatics Dr. Perkins continues to treat patients as an attending hospitalist.

How their research is transforming health care

Dr. Nicholas perkins is dually board certified in clinical informatics and internal medicine. His areas of research interest tend to be in areas that bridge these two realms and include the utilization of large healthcare datasets in research and operations, the production of clinical decision support tools, and monitoring overall healthcare quality. Examples of this research include a grant-based partnership with the Society of Critical Care Medicine and Cure ID to help identify optimal treatment strategies for Covid-19 throughout the pandemic. Dr. Perkins has also started utilizing Epic’s Cosmos database for projects ranging from national antimicrobial resistance patterns to hepatitis trends. He is now partnering with Clemson Assistant Professor Sarah Floyd, PhD to evaluate Cosmos as a tool for orthopedic quality. Finally, he has recently partnered with another CUSHR member, Arwen Declan, MD, PhD, MPhil, DipABLM, Clinical Assistant Professor at Clemson and USC-SOM to investigate optimal technical security strategies for emergency room computing devices from a human interface and workflow efficiency perspective.

Health research keywords

Informatics, healthcare big data, clinical decision support, patient reported outcomes, analytics, human computer interaction, healthcare interfaces, healthcare interoperability, healthcare outcomes, social determinants of health

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